TIBBS Career Blitz Career Profile Questionnaire
Career Profile:
What is your current title and how long have you worked in your current job?
M. Arthur Moseley, PhD
Director, Proteomics and Metabolomics Shared Resource
Associate Research Professor, Department of Medicine
Center for Genomic and Computational Biology
Center for Applied Genomics & Precision Medicine
Duke University School of Medicine
Eight years
Where did you get your PhD and what discipline was it in?
UNC department of Chemistry
Analytical Chemistry (nanoscale separation systems coupled to mass spectrometry)
Dissertation under Professor James J. Jorgenson
Did you do a postdoc?
Industrial Postdoc at Glaxo; Department of Drug Metabolism.
Sixteen years managing mass spectrometry laboratories at Glaxo, GlaxoWellcome,
GlaxoSmithKline, primarily in the field of proteomics.
What are your main daily responsibilities?
As the Director of the Proteomics and Metabolomics Shared Resource at Duke’s
Center for Genomic and Computational Biology, I have overall responsibility and
oversight for the operation, scheduling, maintenance, performance evaluation,
safety, and troubleshooting of the all proteomics and metabolomics work in the
facility. Our Facility provides the capabilities for a wide variety of experiments,
including: 1) open (unbiased) qualitative and quantitative LC/LC/ESI/MS/MS
analyses, using tandem mass spectrometers coupled with ultra-performance
multidimensional nanoscale capillary liquid chromatographs, providing high
resolution, accurate mass data for confident identifications and high quantitative
reproducibility; 2) quantitative and qualitative characterization of posttranslationally enriched sub-proteomes, including phosphoproteomics, acetylomics,
and ubiquitinomics; 3) targeted protein/peptide/metabolite quantitation, providing
high sensitivity, high specificity and excellent quantitative reproducibility using
multiple reaction monitoring (MRM) on a triple quadrupole mass spectrometer; and
4) structural proteomics analyses using HDx, protein footprinting and crosslinking
UPLC/MS/MS.
What are the keys to success in your career field?
1) Receiving a top-quality education at UNC
2) Volunteering to serve in local discussion groups (Triangle Mass Spectrometry
Discussion Group)
3) Participating in national societies related to my field
4) Networking with leaders in the field at national meetings
5) Obtaining permission from our national society, the American Society for Mass
Spectrometry, to teach a short course at the ASMS national meeting (for past 19
years)
What were the most important factors in choosing your career path?
Genuine love of science, which was long-standing as my father was a Chemistry
Professor. A strong desire to work in a field with career potential, but also one
which could contribute to the advancement of science.
What activities (if any) did you participate in that helped you be successful in
obtaining your job?
(from above):
1) Volunteering to serve in local discussion groups (Triangle Mass Spectrometry
Discussion Group)
2) Participating in national societies related to my field
3) Networking with leaders in the field at national meetings
4) Obtaining permission from our national society, the American Society for Mass
Spectrometry, to teach a short course at the ASMS national meeting (for past 19
years)
What 1 or 2 pieces of advice do you have for people who want to land a job like
yours?
1) Be willing to work long-hours.
2) Actively network with leaders in your field.