Introductory NONMEM & PDx-Pop
Date of Meeting:
1 – 2 March, 2016
Location:
Doubletree by Hilton San Francisco Airport, 835 Airport Boulevard, Burlingame, CA 94010
Instructors:
Robert J. Bauer, Ph.D., Brian Sadler, Ph.D.
Agenda Items:
DAY 1 - "Introductory NONMEM & PDx-Pop" - Presentation:
Time
1.
Course Introduction
9:00 –
9:15 AM
2.
Introduction to Population Pharmacokinetics (2hrs)
- Classical Population Analysis Principles/Methodologies
- Sums of Squares Objective Functions
- Extended Least Squares
- Fixed and Random effects
- Population Analysis Methods
- First Order
- First Order Conditional Estimation
- Model Development & Diagnostics
- data exploration
- structural and error model development
- goodness of fit diagnostics
- diagnostic plots
9:15 –
11:15 AM
3.
Coffee Break
11:15 –
11:30 AM
4.
Analysis of Data from One Subject (3hrs)
- Example (PK, Variance Models)
- Introduction to NONMEM Files and Analysis
11:30 –
12:30 AM
5.
Lunch
12:30 –
1:30 AM
6.
Analysis of Data from One Subject (continued)
1:30 –
3:30 PM
7.
Break
3:30 –
3:45 PM
8.
Population Analysis with No Covariates (1.75hrs)
3:45 –
5:30 PM
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DAY 2 – "Introductory NONMEM & PDx-Pop" - Presentation:
Time
1.
Population Analysis with No Covariates (continued)
8:30 –
9:00 AM
2.
Population Analysis with Covariates (3.25hrs)
- NONMEM Files
- Exploratory Analysis
- Model Building Example
9:00 –
10:00 AM
3.
Break
10:00 –
10:15 AM
4.
Population Analysis with Covariates (continued)
10:15 –
11:30 AM
5.
Lunch
11:30 –
12:30 AM
6.
Population Analysis with Covariates (continued)
12:30 –
1:30 PM
7.
Introduction to Model Evaluation Methods
- User-Written Models in NONMEM (1.75hrs)
* A PK-PD Example
* NONMEM Files
1:30 –
2:30 PM
8.
Break
2:30 –
2:45 PM
9.
User-Written Models (continued)
PK-PD Model Problem
2:45 –
3:30 PM
10.
Population Analysis Final Example & Practice Session
3:30 –
5:00 PM
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