SCIENTIFIC WORK
MAIN SCIENTIFIC RESEARCHES
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The theory and methodology of the hygienic regulation of xenobiotics
and their mixtures, toxicology and hygienic standardization of harmful
chemical substances (heavy metals, pesticides) and their conbinations
in the environmental objects.
The theory and methodology of the normative protection of people
under conditions of chemical accidents, the experimental background
of the xenobiotics standards and their mixtures of chemical accidents.
The study of reason-consequence links in the system of environment –
xenobiotics – health to prevent ecopathology, the theory and
methodology of regional standards of xenobiotics.
The study and hygienic evaluation of the toxicity of xenobiotics on the
background of unsufficient iodine supply for organizm, the combined
effect of iodine deficiency and other environmental factors on
children's health.
MAIN SCIENTIFIC ACHIEVEMENTS OF DEPARTMENT
There have been developed:
 original concepts of cumulative xenobiotics, the combined ef fect and
hygienic estimation of their mixtures, the systematic standardization
of xenobiotics in different environments for usual and extreme
conditions;
 the criteria and methods of study and evaluation of the toxication,
cumulation of xenobiotics and their mixtures, the expressexperimental background of safe levels of xenobiotics activity, the
complex express method of background the systematized standards of
substances in different environments, methods of study of the skin absaptive toxycity, stability and transformation of chemical substances
in the water of reservoirs;
 15 national and international documents on hygienic regulation of
xenobiotics and their mixtures, including Methodological guidelines
MG 1.1.5.-088-02 "Substantiation of hygienic standards of harmful
chemicals in different environments in a systematic approach"
 maximum acceptable concentration (over 100) in different
environmental objects, as weel as 20 harmful substances for the
conditions of chemical accidents;
 physical development standards of children of preschool age;
 experimental model of iodine deficiency for toxicological studies;
 prevention measures of thyreotoxicity of lead under conditions of
iodine deficiency;
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criteria for the formation of the unsatisfactory adaptation and complex
of preventive measures for its improvement in the 6 -7-year-old pupils
of boarding schools in the region of iodine deficiency;
measures of reduce the risk of autoimmune thyroiditis in iodine
deficiency region;
measures of prevention, diagnosis and treatment of inhalation
poisoning liquidators and population at phosphate accidents.
5 monographs have been published, 3 certificates and one declaration
patent have been obtained, over 1000 articles have been published, 6 DSci,
35 PhD and 3 master’s degree theses have been ecomplesht of the founding
of chair.
THEMES OF SRW LAST DECADE
HYGIENIC ASSESSMENT OF XENOBIOTICS TOXICITY
(LEAD BY EXAMPLE) AGAINST THE BACKGROUND ON INSUFFICIENT IODINE
SUPPLY OF ORGANISM
(2003-2007)
Scientific adviser – MD, PhD, associate professor B.A. Plastunov
Responsible executor – DSci., professor B.M. Shtabskyi
Performers –А.К. Мanenko, Dr., Professor; V.М. Тоmkiv, PhD, Associate Professor;
Assistants S.T. Zub, L.V. Plastunova, H.М. Тkаchenko, PhD, O.P. Каsiyan
Abstract
Report on the research work: 111 p., 37 figures, 15 tables, 157 bibliographic sources.
Object of study – morphofunctional state of the thyroid gland, processes of peroxidation
and antioxidant defense in blood and tissues of experimental animals under the lead influence in
iodine deficiency modeled by introduction of medicinal thyrostatics mercazolil.
Purpose of research – to examine the toxic properties of lead in insufficient iodine supply
of organism, to work out the methodological approaches to the prevention study of chemical
ecopatology in areas of goiter endemia.
Research methods – analytical and theoretical, biological modeling, histological,
biochemical.
The effects of different doses of lead nitrate in secondary iodine deficiency caused by
medical thyrostatics mercazolil were studied in experiment. It was investigated increasing the
thyreotoxicity of lead in iodine deficiency, which is accompanied by disturbances in the
antioxidant defense system and activation of free radical reactions in blood and tissues. The
obtained results of the investigations have shown that traditional prevention of iodine deficiency
is insufficiently effective against the background of high lead intake and slowing preventive
effect of potassium iodide at low levels of lead exposure. Using of L-arginine to reduce the
effects of oxidative stress caused by lead intoxication is perspective.
LEAD, THYROID GLAND, IODINE DEFICIENCY, MERCAZOLIL, MODELING,
IODOPROPHYLACTIC, L-ARGININE, ANTIOXIDANT DEFENSE
According to the results of research the Dissertation for obtaining scholarly degree of
candidate of medical sciences was defended (S.T. Zub, State Foundation “O.M. Marzyeyev
Institute for Hygiene and Medical Ecology of National Academy of Medical Sciences of
Ukraine”, 2010), 53 articles, 27 abstracts and an informational letter have published.
HYGIENIC ASSESSMENT OF COMBINED INFLUENCE OF IODINE DEFICIENCY
AND OTHER FACTORS OF HABITAT ON CHILDREN'S HEALTH
(2008-2012)
The supervisor – MD, PhD, associate professor B.A. Plastunov
Responsible executor – MD, PhD, assistent professor S.T. Zub
Еxecutors – DSci., professor А.V. Mahlovanyi, DSci., professor А.К. Manenko,
MD, PhD В.М. Томків, PhD, associate professor О.B. Kunynets, PhD, associate
professor V.P. Chomyshyn, MD, PhD, associate professor L.V. Riza, assistents
professor M.I. Zavada, M.O. Kovaliv, MD, PhD O.P. Kasiyan
ABSTRACT
Report on the research work: 267 p., 2 figures, 138 tables, 360 bibliographic sources.
Object of study – morphofunctional development and adaptation status o f
primary school children - pupils of boarding schools and students of higher medical
educational institution, morbidity at autoimmune thyroiditis and childhood infections
in the region of iodine deficiency.
Purpose of work - to examine the health of children and students, especialles of
their adaptation to learning and prevalence of diseases under the combined effect of
iodine deficiency and other priority of harmful environmental factors in endemic
region and to develop a complex of adequate preventive measures on this basis.
Research methods - analytical and theoretical, sanitary and hygienical,
epidemiological,
anthropometric,
biochemical,
physiological,
physiological,
mathematical and statistical.
Unbalanced irrational food and iodine deficiency have a a leading role in the
complex environmental factors of children of primary school age in secondary
boarding schools which lead to inhibition of the morphofunctional development and
adaptation processes of children. It has been proved the influence of iodine and
exposure of the organism by lead on physical health and functional status of the
cardiovascular system and the intellectual development of students. It was determined
the role of unfavorable environmental factors in the development of autoimmune
thyroiditis and risks of its occurrence in iodine deficiency region. Complex preventive
measures to improve the adaptation of primary school children with complicated
social history and students, reduce the risk of autoimmune thyroiditis among the
population in the region of iodine deficiency has been suggested , methodological
approach to the analysis of causal relationships between infectious disease ща
pediatric population and indicators of pollution was justified.
CHILDREN,
BOARDING
SCHOOLS,
MORBIDITY, IODINE DEFICIENCY, LEAD
STUDENTS,
ADAPTATION,
As the results of SRW the theses were defended (O.P. Kassiyan, O.M.
Kolinkovskyy, O.M. Marzeev Institute of Hygiene and Medical Ecology AMS of
Ukraine, 2012), given to the defence of thesis (M. I. Zavada ), any thesis is done
(M.A. Kovaliv), published 84 articles and 63 abstracts, published a monograph,
recommendations stamped Ministry of Health of Ukraine, 3 letters of information,
received patent.