1. Tinea incognito due to microsporum gypseum. J Biomed Res, 2010;
24(1):81-83
Chunshui Yu, Jingguo Zhou, Jianping Liu
Department of Dermatology, the Affiliated Hospital of North Sichuan Medical
College, Nanchong, Sichuan 637000, China.
Abstract: A 41-year-old woman presented with a pruritic rash on the face that was of 3
months duration. During that time, it had been successively misdiagnosed as psoriasis
vulgaris, systemic lupus erythematosus, facial dermatitis at other hospitals, and had
been treated with agents that included acitretin and prednisone. Finally, fungi were
found in the lesions by optical microscopy, and the fungal culture was positive for
Microsporum gypseum, and was diagnosed as a Microsporum gypseum infection. The
lesions eventually cleared completely after 8 weeks of antifungal treatment.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=jbr100113&flag=1
2. Efficacy and tolerance of tacrolimus and pimecrolimus for atopic dermatitis:
a meta-analysis. J Biomed Res, 2011; 25(6):385-391
Zhiqiang Yina, Jiali Xub, Dan Luoa
a
Department of Dermatology; b Department of Oncology, the First Affiliated
Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Abstract: Tacrolimus ointment and pimecrolimus cream have proved to be suitable for
the treatment of atopic dermatitis. We conducted a meta-analysis of the efficacy,
adverse events/withdrawal of tacrolimus versus pimecrolimus in the treatment of
atopic dermatitis. According to our meta-analysis, 0.1% tacrolimus was more
effective than 1% pimecrolimus in the treatment of adult patients and moderate to
very severe pediatric patients, and more 0.1% mild pediatric patients treatal with
pimecrolimus withdrew from the trials because of a lack of efficacy or the occurrence
of adverse events, compared with mild pediatric patients treated with 0.03%
tacrolimus. The combined analyses of tacrolimus with pimecrolimus showed that
tacrolimus was more effective than pimecrolimus (week 3: RR=0.67,
95%CI=0.56-0.80; week 6/end of study: RR=0.65, 95%CI=0.57-0.75), and fewer
tacrolimus-treated patients withdrew because of a lack of efficacy (RR=0.32,
95CI%=0.19-0.53) or the occurrence of adverse events (RR=0.43, 95%CI=0.24-0.75),
compared with pimecrolimus-treated patients. In conclusion, tacrolimus has higher
efficacy and better tolerance than pimecrolimus in the treatment of atopic dermatitis.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR110602&flag=1
3. Baicalin modulates microRNA expression in UVB irradiated mouse skin. J
Biomed Res, 2012; 26(2):125-134
Yang Xu, Bingrong Zhou, Di Wu, Zhiqiang Yin, Dan Luo
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical
University, Nanjing, Jiangsu 210029, China.
Abstract: This study aimed to evaluate the effects of baicalin on ultraviolet radiation
B (UVB)-mediated microRNA (miRNA) expression in mouse skin. We determined
miRNA expression profiles in UVB irradiated mice, baicalin treated irradiated mice,
and untreated mice, and conducted TargetScan and Gene Ontology analyses to predict
miRNA targets. Three miRNAs (mmu-miR-125a-5p, mmu-miR-146a, and
mmu-miR-141) were downregulated and another three (mmu-miR-188-5p,
mmu-miR-223 and mmu-miR-22) were upregulated in UVB irradiated mice
compared with untreated mice. Additionally, these miRNAs were predicted to be
related to photocarcinogenesis, hypomethylation and apoptosis. Three miRNAs
(mmu-miR-378, mmu-miR-199a-3p and mmu-miR-181b) were downregulated and
one (mmu-miR-23a) was upregulated in baicalin treated mice compared with UVB
irradiated mice, and they were predicted to be related to DNA repair signaling
pathway. These deregulated miRNAs are potentially involved in the pathogenesis of
photodamage, and may aid treatment and prevention of UVB-induced dermatoses.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR120209&flag=1
4. UVA1 irradiation inhibits fibroblast proliferation and alleviates pathological
changes of scleroderma in a mouse model. J Biomed Res, 2012; 26(2):135-142
Mei Ju, Kun Chen, Baozhu Chang, Heng Gu
Institute of Dermatology, Chinese Academy of Medical Science, Nanjing, Jiangsu
210042, China.
Abstract: The purpose of the present study was to compare the effects of different
doses of ultraviolet radiation A1 (UVA1) on human fibroblast proliferation and
collagen level in a mouse model of scleroderma, so as to identify appropriate
irradiation doses for clinical treatment of scleroderma. Monolayer from human
fibroblasts was cultured in vitro, and a mouse model of scleroderma was established by
subcutaneous injection of 100 μL of 400 μg/mL bleomycin into the back of BALB/c
mice for 4 weeks. The mouse models and human fibroblasts were divided into
UVA1-exposed (100, 60 and 20 J/cm2) and UVA-unexposed groups. At 0, 24 and 48
h after exposure, cell proliferation and levels of hydroxyproline and collagen were
detected. UVA1 irradiation was performed 3 times weekly for 10 weeks, and the
pathological changes of skin tissues, skin thickness and collagen level were observed
after phototherapy. Cell proliferation and the levels of hydroxyproline and collagen
were inhibited after phototherapy, and there was a significant difference between the
UVA1-exposed cells and UVA1-unexposed cells (P < 0.001). In addition, UVA1
phototherapy improved dermal sclerosis and softened the skin, and there were
significant differences between the high-dose UVA1 group and the model group, and
the negative group (P < 0.05). It is concluded that UVA1 radiation can reduce cell
proliferation, and decrease hydroxyproline and collagen levels in a dose-dependent
manner in vitro. High-dose UVA1 phototherapy has marked therapeutic effect on
scleroderma in the mouse model. Decreased collagen level may be related to the
reduced number and activity of cells, as well as inhibition of collagen synthesis.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR120210&flag=1
5. Hydrogen-rich saline protects against ultraviolet B radiation injury in rats. J
Biomed Res, 2012; 26(5):365-371
Ze Guoa, Bingrong Zhoua, Wei Lia, Xuejun Sunb, Dan Luoa
a
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical
University, Nanjing, Jiangsu 210029, China;
b
Department of Diving Medicine, Faculty of Naval Medicine, Second Military
Medical University, Shanghai 200433, China.
Abstract: Exposure of skin to solar ultraviolet (UV) radiation induces photo-damage.
Ultraviolet B (UVB) is the major component of UV radiation which induces the
production of reactive oxygen species (ROS) and plays an important role in
photo-damage. Hydrogen gas reduces ROS and alleviates inflammation. In this study,
we sought to demonstrate that hydrogen-rich saline has the effect on skin injuries
caused by UVB radiation. UVB radiation was irradiated on female C57BL/6 rats to
induce skin injury. Hydrogen-rich saline and nitrogen-rich saline were administered to
rats by intraperitoneal injection. Skin damage was detected by microscope after injury.
UVB radiation had a significant affection in tumor necrosis factor alpha, interleukin
(IL)-1β and IL-6 levels, tissue superoxide dismutase, malondialdehyde and nitric
oxide activity. Hydrogen-rich saline had a protective effect by altering the levels of
these markers and relieved morphological skin injury. Hydrogen-rich saline protected
against UVB radiation injury, possibly by reducing inflammation and oxidative stress.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR120508&flag=1
6. Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an
organ culture model. J Biomed Res, 2012; 26(5):372-380
Wenrong Xua, Weixin Fana, Kun Yaob
a
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical
University, Nanjing, Jiangsu 210029, China;
b
Department of Microbiology and Immunology, Nanjing Medical University, Nanjing,
Jiangsu 210029, China.
Abstract: Hypertrichosis is one of the most common side effects of systemic
cyclosporine A therapy. It has been previously shown that cyclosporine A induces
anagen and inhibits catagen development in mice. In the present study, to explore the
mechanisms of cyclosporine A, we investigated the effects of cyclosporine A on hair
shaft elongation, hair follicle cell proliferation, apoptosis, and mRNA expression of
selected growth factors using an organ culture model of mouse vibrissae. In this
model, cyclosporine A stimulated hair growth of normal mouse vibrissae follicles by
inhibiting catagen-like development and promoting matrix cell proliferation. In
addition, cyclosporine A caused an increase in the expression of vascular endothelial
growth factor (VEGF), hepatocyte growth factor (HGF), and nerve growth factor
(NGF), and inhibited follistatin expression. Our findings provide an explanation for
the clinically observed effects of cyclosporine A on hair growth. The mouse vibrissae
organ culture offers an attractive model for identifying factors involved in the
modulation of hair growth.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR120512&flag=1
7. Favre-Racouchot syndrome associated with eyelid papilloma: a case report
Ruzhi Zhanga, Wenyuan Zhub*
a
Department of Dermatology, the First Affiliated Hospital of Bengbu Medical
College, Bengbu, Anhui 233004, China;
b
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical
University, Nanjing, Jiangsu 210029, China.
Abstract: A 55-year-old Chinese man presented with an asymptomatic pedunculated
elevation on his left lower eyelid which had been gradually increasing in size during
the past three years. The patient was diagnosed with eyelid papilloma by pathological
examination. Concomitantly, the patient developed open comedones with a bilateral
linear distribution, along with oblique wrinkle lines in his infraorbital regions. These
lesions were noninflammatory and remained unchanged for two years. To the best of
our knowledge, this distribution of open comedones, especially in combination with
eyelid papilloma, has not been reported previously in Favre-Racouchot syndrome.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?flag=1&file_no=JBR120611