P143 THE ECONOMIC IMPLICATIONS OF IMPROVEMENT IN BLOOD PRESSURE CONTROL IN PRIMARY CARE DRIVEN BY THE RENAL QUALITY OUTCOMES FRAMEWORK (QOF) INDICATORS Irving, J, Hobbs, H, Kilbride, H, Karunaratne, Kingston, R, Stevens, P, Farmer, C Kent Kidney Care Centre, East Kent Hospitals University NHS Foundation Trust INTRODUCTION: The introduction of renal indicators into the Quality and Outcomes Framework (QOF) has promoted monitoring and control of hypertension to a target BP of <140/85. We have shown that since the introduction of these indicators there has been a highly significant reduction in blood pressure and an increase in antihypertensive prescription in people with stage 3-5 CKD. AIM: This study aims to provide a cost benefit analysis of implementing the renal QOF indicators on blood pressure and antihypertensive medication prescription in people with CKD. METHODS: Data were extracted as part of the SEIK project* on a total population of 36,519 individuals from primary care during a 4 year study period. The study period was split into two groups, Pre QOF (Group 1: 1/4/2004-1/4/2006) and post QOF (Group 2:1/4/2006-1/4/2008). Patients were selected from this data if they had GFR estimations and blood pressure readings in both study periods. Patient demographics, mean and median GFR, blood pressure and anti hypertensive prescriptions for each patient in each of the two periods were extracted. Patients were designated as hypertensive if they had a mean BP >140/85 or were prescribed antihypertensive drugs in the preQOF period. Stage of CKD was also assessed using the mean GFR in the pre-QOF period. An estimate of the annual cost of treatment of hypertension was made for both study periods based on prescriptions written. Costs were also calculated on the basis of global generic prescribing. RESULTS: 32,770 patients had GFR and blood pressure measurements in both study periods. 24,088 of these were hypertensive and 5,901 were both hypertensive and had CKD 3-5 in the pre QOF period. Our previous study has demonstrated a significant blood pressure reduction in people with CKD 3-5 (7/3mmHg). Diuretic Beta-blocker Alpha-blocker Calcium channel blocker ACE inhibitor ARB Other Number 624 390 213 pre QOF Actual cost £ 26,829 10,910 8,280 Generic cost £ 6,065 4,025 7,566 407 2,904 1,166 30 45,736 85,777 191,012 2,955 6,056 51,924 191,012 6,000 5,734 371,499 309,006 Totals Table showing costs for hypertensive patients with CKD 3-5. Number 1,780 1,166 430 post QOF Actual cost £ 38,754 36,527 16,946 Generic cost £ 17,127 11,847 15,203 1,080 2,186 1,451 45 123,585 59,594 235,328 5,625 15,892 38,692 235,328 9,000 8,138 516,358 388,756 CONCLUSION: This study demonstrates that introduction of renal indicators in the QOF has significantly increased anti-hypertensive prescribing resulting in a 40% increase in prescribing costs. Payments for achievement of QOF targets will have further increased costs. However, a significant proportion of these costs would be offset if all drugs were prescribed generically. The increased cost is approximately £25.00 per patient treated which, given the reduction in blood pressure achieved is well within the cost effective threshold of £30K per quality adjusted life year (QALY) outlined in NICE guidelines. * The SEiK project is a decision support system used in primary care which analyses data on patients who have had serum creatinine tests.