Incidence of fatal food anaphylaxis in people with food
allergy: a systematic review and meta-analysis
Thisanayagam Umasunthar clinical research fellow1,2, Jo Leonardi-Bee, associate
professor in epidemiology3, Matthew Hodes, senior lecturer in child and adolescent
psychiatry 2,4, Paul J. Turner, clinical lecturer in paediatric allergy1,2, Claudia Gore,
consultant in paediatric allergy1,2, Parviz Habibi, consultant in paediatric respiratory
medicine1,2, John O. Warner professor of paediatrics1,2, Robert J. Boyle, senior
lecturer in paediatric allergy1,2
1Department
of Paediatrics, Imperial College London, Norfolk Place,London W2 1PG
UK
2
Imperial College Healthcare NHS Trust, St Mary's Hospital, Praed Street, London
W2 1NY UK
3
Division of Epidemiology and Public Health, University of Nottingham NG5 1PB UK
4
Academic Unit of Child and Adolescent Psychiatry, Imperial College London,
Norfolk Place, London W2 1PG UK
Address for Correspondence:
Robert Boyle
Wright Fleming Building
Norfolk Place
London W2 1PG
Tel: +44 207 594 3990 Fax: +44 207 594 3984. Email: r.boyle@nhs.net
Medline Search strategy
1. exp Anaphylaxis/
2. anaphyl*.mp. [mp=title, abstract, original title, name of substance word, subject
heading word, protocol supplementary concept, rare disease supplementary
concept, unique identifier]
3. exp Food Hypersensitivity/
4. Food/
5. food*.mp. [mp=title, abstract, original title, name of substance word, subject
heading word, protocol supplementary concept, rare disease supplementary
concept, unique identifier]
6. 1 or 2
7. 3 or 4 or 5
8. 6 and 7
9. exp Emergency Medical Services/
10. emergency department.mp. [mp=title, abstract, original title, name of substance
word, subject heading word, protocol supplementary concept, rare disease
supplementary concept, unique identifier]
11. Emergencies/
12. exp Hospitalization/
13. hospital admission*.mp. [mp=title, abstract, original title, name of substance
word, subject heading word, protocol supplementary concept, rare disease
supplementary concept, unique identifier]
14. Patient Admission/
15. exp Fatal Outcome/
16. fatal*.mp. [mp=title, abstract, original title, name of substance word, subject
heading word, protocol supplementary concept, rare disease supplementary
concept, unique identifier]
17. exp Mortality/
18. incidence.mp. or Incidence/
19. prevalence.mp. or Prevalence/
20. 9 or 10 or 11
21. 12 or 13 or 14
22. 15 or 16 or 17
23. 18 or 19
24. 8 and 20
25. 8 and 21
26. 8 and 22
27. 8 and 23
28. 24 or 25 or 26 or 27
Potentially eligible studies with no episodes of fatal food anaphylaxis recorded
1.
Bohlke K, Davis RL, DeStefano F, Marcy SM, Braun MM, Thompson RS.
Epidemiology of anaphylaxis among children and adolescents enrolled in a health
maintenance organization. J Allergy Clin Immunol. 2004;113(3):536-42.
2.
Braganza SC, Acworth JP, Mckinnon DRL, Peake JE, Brown AFT. Paediatric
emergency department anaphylaxis: different patterns from adults. Arch Dis Child.
2006;91(2):159-63.
3.
Decker WW, Campbell RL, Manivannan V, Luke A, St Sauver JL, Weaver A,
et al. The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report
from the Rochester Epidemiology Project. J Allergy Clin Immunol. 2008;122(6):11615.
4.
Helbling A, Hurni T, Mueller UR, Pichler WJ. Incidence of anaphylaxis with
circulatory symptoms: a study over a 3-year period comprising 940 000 inhabitants
of the Swiss Canton Bern. Clin Exp Allergy. 2004;34(2):285-90.
5.
Harduar-Morano L, Simon MR, Watkins S, Blackmore C. A population-based
epidemiologic study of emergency department visits for anaphylaxis in Florida. J
Allergy Clin Immunol. 2011;128(3):594-600.e1.
6.
Tejedor M, Moro M, Mugica M, Esteban J, Gomez-Traseira C, Remedios C, et
al. Incidence of anaphylaxis in Alcorcon city, Spain: A population-based study.
Allergy. 2011;66:110.
7.
Vetander M, Helander D, Flodstrom C, Ostblom E, Alfven T, Ly DH, et al.
Anaphylaxis and reactions to foods in children - a population-based case study of
emergency department visits. Clin Exp Allergy. 2012;42(4):568-77.
8.
Peng MM, Jick H. A Population-Based Study of the Incidence, Cause, and
Severity of Anaphylaxis in the United Kingdom. Arch Intern Med. 2004;164(3):317-9.
9.
Ross MP, Ferguson M, Street D, Klontz K, Schroeder T, Luccioli S. Analysis
of food-allergic and anaphylactic events in the National Electronic Injury Surveillance
System. J Allergy Clin Immunol. 2008;121(1):166-71.
10.
Yocum MW, Butterfield JH, Klein JS, Volcheck GW, Schroeder DR,
Silverstein MD. Epidemiology of anaphylaxis in Olmsted County: A population-based
study. J Allergy Clin Immunol. 1999;104(2):452-6.
11.
Mulla ZD. Hospitalizations of children and young adults from peanut-induced
anaphylaxis in Texas. South Med J. 2011;104(5):322-4. Epub 2011/05/25.
12.
Mulla ZD, Simon MR. Hospitalizations for anaphylaxis in Florida:
epidemiologic analysis of a population-based dataset. Int Arch Allergy Immunol.
2007;144(2):128-36. Epub 2007/05/31.
13.
Ho MHK, Wong LM, Ling SC, Kwok KL, Lee KP, Hui J, et al. Clinical
characteristics and etiologies of severe systemic allergic reaction amongst children
admitting to hospital authority paediatric service. Hong Kong Journal of Paediatrics.
2009;14 (4):297.
14.
Gonzalez-Perez A, Aponte Z, Vidaurre CF, Rodriguez LAG. Anaphylaxis
epidemiology in patients with and patients without asthma: A United Kingdom
database review. J Allergy Clin Immunol. 2010;125(5):1098-104.