www.birdsrl.it
our
program
for
Sexually
Transmitted
Infections
Biotecnologia Innovativa per Ricerca e Diagnostica
STI
The sexually-transmitted infections
comprehensive panel
BIRD R&D division can interact with customers to develop special products, according to particular needs,
although not included in the product list. Thanks to a sound and long-lasting experience in molecular
diagnostics, we are able to quickly develop kits, protocols and reagents for the detection of pathogens,
gene mutations or expression profiles on the main platforms of molecular diagnostics:
PCR, Real-Time PCR, sequencing, microarrays, beads arrays.
Thanks to this formula, we can cover a virtually unlimited range of niche applications and experimental
diagnostics, merging flexibility and customization with industrial criteria of quality and standardization.
A direct collaboration with customers often results in long-lasting partnerships.
The request for custom product development can be activated by direct contact with BIRD after a preliminary interaction with our agents in the area. We believe that molecular diagnostics, that has today become
an established diagnostic tool in the clinical laboratory, is still far from having expressed its full potential, either in terms of technology and application range. That is the reason why we consider the proposals of our
customers as a way to broaden the list of useful applications, based and still unmet on real needs stemming
from the clinical setting.
Go molecular at the cost of colture!
BIRD is affiliated to Toscana Life Sciences
The Toscana Life Sciences (TLS) Foundation is a non-profit organization with the objective
of supporting research activities in the Life Sciences and, in particular, of sustaining the
development of projects from basic research to industrial application.
HEADQUARTER
via Montarioso 9c
53035 - Monteriggioni (SI)
tel +39.0577.588442
fax +39.0577.591097
e-mail: info@birdsrl.it
pec: birdsrl@pec.it
web: www.birdsrl.it
R&D and MANUFACTURING
via Papa Giovanni XXIII 75a
25086 - Rezzato (BS)
tel +39.030.2592041
fax +39.030.2596187
e-mail: rd@birdsrl.it
§
Quantitative Real-Time PCR kits covering the most clinically
relevant ST infections
§
Singleplex, multiplex or combo format options for every routine need and volumes
§
Sensitive, specific, quick, ease-to-use format
§
To be used on isolates or directly on clinical samples (blood,
biopsies, respiratory specimens, swabs)
§
Extraction kit and extraction protocols for different samples
included
§
Protocol including sampling quality control
www.birdsrl.it
SEXUALLY TRANSMITTED DISEASES:
A GLOBAL BURDEN
Biotecnologia Innovativa per Ricerca e Diagnostica
Species
Format
Code
Availability
Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis - triplex
Chlamydia trachomatis, Neisseria gonorrhoeae - duplex
Trychomonas vaginalis
Mycoplasma genitalium
Mycoplasma hominis
Ureaplasma urealyticum
Ureaplasma parvum
Mycoplasma multiplex 1(M.genitalium, M.hominis, U.urealyticum)
Mycoplasma multiplex 2 (M.genitalium, T.vaginallis)
Mycoplasma multiplex 3 (M.genitalium, U.urealyticum)
Mycoplasma multiplex 4 (M.hominis, U.parvum)
Gardenerella vaginalis
STI combo
Treponema pallidum
HSV 1/2
25/50
25/50
25/50
25/50
25/50
25/50
25/50
25/50
25/50
25/50
25/50
25/50
20
25/50
25/50
B042.25/B042
B043.25/B043
P031.25/P031
B009.25/B009
B010.25/B010
B011.25/B011
B012.25/B012
B038.25/B038
B037.25/B037
B039.25/B039
B040.25/B040
B030.25/B030
B041
B028.25/B028
V015.25/V015
Available
Available
Available
Available
Available
Available
Coming soon
Available
Available
On request
On request
Available
On request
On request
On request
Atopobium vaginae
Lactobacillus spp
Lactobacillus iners
Lactobacillus crispatus
25/50
25/50
25/50
25/50
B031.25/B031
B032.25/B032
B033.25/B033
B034.25/B034
On request
On request
On request
On request
HPV 12 HR Screening – Quant
HPV 14 HR Screening
HPV 14 HR Typing – Quant
HPV 12 HR Typing
HPV 12 HR & 2 LR Typing
100
50
100
50
50
HPV01
HPV02
HPV03
HPV04
HPV05
Available
Available
Available
Available
Available
Candida spp
Candida albicans
Candida glabrata
Candida parapsilosis
Candida tropicalis
Candida krusei
Candida multiplex 1 (C.spp, C.albicans)
Candida multiplex 2 (C.glabrata, C.parapsilosis)
Candida multiplex 3 (C.tropicalis, C.krusei)
Candida Combo
25/50
25/50
25/50
25/50
25/50
25/50
25/50
25/50
25/50
20
M006.25/M006
M007.25/M007
M008.25/M008
M010.25/M010
M011.25/M011
M022.25/M022
M023.25/M023
M024.25/M024
M025.25/M025
M026
Available
Available
Available
Available
Available
Coming soon
Available
Coming soon
Coming soon
On request
Sexually transmitted infections (STI), also referred to as sexually transmitted diseases (STD) and venereal
diseases (VD), are infections that are commonly spread by sex. Most STIs initially do not cause symptoms.
This results in a greater risk of passing the disease on to others. STIs acquired before or during birth may
result in poor outcomes for the baby. Some STIs may cause problems with the ability to get pregnant.
More than 30 different bacteria, viruses, and parasites can cause STIs. Bacterial STIs include chlamydia, gonorrhea,
and syphilis among others. Viral STIs include genital herpes HIV/AIDS, and genital warts among others. Parasitic
STIs include trichomoniasis among others. While usually spread by sex, some STIs can also be spread by
non-sexual contact with contaminated blood and tissues, breastfeeding, or during childbirth. STIs represent a sigInificant diseas burden globally. In 2008, it was estimated that 500 million people were infected
with either syphilis, gonorrhea, chlamydia or trichomoniasis. At least an additional 530 million people
have genital herpes and 290 million women have human papillomavirus. In the United States there were
19 million new cases of sexually transmitted infections in 2010.
Chlamydia is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis. In women,
symptoms may include abnormal vaginal discharge, burning during urination, and bleeding in between
periods, although most women do not experience any symptoms. Symptoms in men include pain when
urinating, and abnormal discharge from their penis. If left untreated in both men and women, Chlamydia
can infect the urinary tract and potentially lead to pelvic inflammatory disease (PID). PID can cause
serious problems during pregnancy and even has the potential to cause infertility. It can cause a woman
to have a potentially deadly ectopic pregnancy.
The two most common forms of herpes are caused by infection with herpes simplex virus (HSV). HSV-1 is
typically acquired orally and causes cold sores, HSV-2 is usually acquired during sexual contact and affects
the genitals, however either strain may affect either site.
Some people are asymptomatic or have very mild symptoms. Those that do experience symptoms usually
notice them 2 to 20 days after exposure which last 2 to 4 weeks. Symptoms can include small fluid-filled
blisters, headaches, backaches, itching or tingling sensations in the genital or anal area, pain during
urination, Flu like symptoms, swollen glands, or fever. Molecular assays have become increasingly popular
for screening and diagnosis of sexually transmitted infections.
Chlamydia detection through molecular assays circumvents the drawbacks of microscopy conventional
tests, which are subjective and lack sensitivity. The detection and typing of High Risk HPV types is now
part of the routine screenig for the carcinoma of the cervix. Molecular diagnostics permits to differentiate
distinct species of Mycoplasma, or the specific detection of Trichomonas vaginalis, thus helping in
detecting and classifying non-gonococcal urethritis and other pathologies of the genitourinary tract.
Also, an invaluable advantage of molecular assays is the possibility of multiplexing the assays, targeting
different pathogens in the same reaction, saving costs and time in analyzing the most common
pathogens causing sexually transmitted diseases.