Thermo-mechanical activation (TMA) technology
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In the past several years we have invested a lot of
knowledge and effort in development and use of this
technology - thermo-mechanical activation (TMA) to
create new natural products and strengthening of
existing products efficacy.
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It has been developed by using the activated particles
of the Silica earth/Clinoptilolite and natural active
substances.
Thermo-mechanical activation is a process based
on the micronization of solid particles by using
specially designed rotor system. Due to the
particle collisions and friction at high speeds in
very short time intervals, physical characteristics
of the treated substance change substantially .
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Since many biochemical processes are associated with
the characteristics of the TMAC (thermo-mechanical
activated Clinoptilolite) such as ion exchange, adsorption
and catalysis, it can be successfully used for the purpose
of the environmental protection, in biology, medicine, and
in the pharmaceutical industry.
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After the initial studies, which have been conducted on
TMAC only, research efforts were further focused on the
problems of the synthesis of TMAC and other natural and
synthetic agents.
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It has been shown that different types of natural active
molecules can be successfully encapsulated within
TMAC particles (“ship in bottle” effect).

Such encapsulated complexes are protected from
oxidation, loss of catalytic characteristics and oxygen
transport of bioactive natural substances. Thereby, their
activity is retained and is almost identical to the free
molecules. Saving of certain ions and molecules in the
channels allow their widespread use, including slow
release of natural active substances.
Benefits of Silica earth/Clinoptilolite products:
1.
2.
3.
4.
5.
Have long-term chemical and biological stability
Reversibly bind small molecules such as oxygen and
nitrogen oxide,
Have the ability to selectivity in terms of size and shape
“Offer” the possibility of the metal-enzymatic mimicry
Have immunomodulatory effects
Characteristics/Benefits of the TMA technology
TMA technology offers the possibility to
design and produce a new generation of
innovative high performance products without
toxic and other side effects based on natural
active substances.
During TMA process there are significant changes in the
biophysical properties of Silica earth/Clinoptilolite (TMAC)
particles and also natural active molecules, such as:
 increase of active surface
 dissociation of crystal water
 augmentation of electrostatic charge, appearance of
redundant partial free and/or free ions and
 high potential for electron donation
 biophysical effect of a wide spectrum of natural and
synthetic substances are substantially enhanced.
TMAC particles encapsulate the natural active molecules
within their channels so they are protected from the:
 oxidation,
 loss of catalytic characteristic and
 transport of oxygen.
Saving of certain ions and molecules in the channels allow
their long-term chemical and biological stability and slow
release with almost the same activity.

TMAC reversibly bind small molecules such
as oxygen and nitrogen oxide, and by
changing the shape and size

TMAC particles have the ability to selectively
bind a certain type of molecules.
Transfer and delivery of medicines

Saving of certain ions and molecules in the channels allow
their widespread use, including slow release of active
drugs.
 Many enzymes can be encapsulated in structure, and
after release they retained almost the same activity
 In USA is being developed using of Clinoptilolite as carrier
of zinc or silver for treatment of skin acne or scar.
TMA technology
Thermo-mechanical activation is a process of fragmentation and micronization of solids
which result with significant enhancement of reactive particle capability and increase of its
energy level
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Elevation of particle energy level is a result of electron, atom and molecule
transfer form one particle crystal structure into another what disrupts the
continuity of crystal structure and thus creates electrostatic charge and weakens
electrostatic bond between crystal structures of particle.

The crystal structure deforms and damages on the surface and in the layers
directly bellow the surface.

Considering also the porous structure of the crystals and the effect of particles
size degradation to the micro and nano level, i.e. the growth of the active
surfaces, all necessary preconditions for the synergy of TMAC and other natural
and synthetic molecules in a substance with new properties are achieved.
TMA technology
Housing consisting of removable sections, two
counter-rotating rotors
Independent drive to the rotors by electromotor
 counter-rotating movement with the same
angle speed
Material is fed in by suction to the
central part of the rotor system
Material is accelerated by airflow
generated by fans
Particle acceleration changes direction at extremely short intervals
(approx. 10-5 to 10-6 sec.)
Transfer and delivery of medicines
Thermo-mechanical activation (TMA) is a newly developed
micronizing method with special equipment (TMA designator)
for improving reaction capacity levels.
After processing, significant changes to the particles can be
observed with regard:
 size
 surface characteristics
 electrostatic charge
 ion exchange capacity
Stages of micronising
1. Particles
are accelerated
4. Dynamics cause
pulverizing
2. Particles collide
5. Dynamic process
continues
3. Particles rebound surface friction
6. Crystal structure
fragments
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Effect “ship in bottle” - Molecules are
encapsulated in Silica earth/Clinoptilolite
Encapsulated complexes are almost identical
as free complexes.
 Encapsulation is protecting from lighting and
loss of catalytically characteristic and
transport of oxygen of bioactive natural
substances.
Picture 1: The structure of Silica earth/Clinoptilolite, thanks to which,
it has very useful properties such as ion exchange, dehydration,
adsorption, catalysis.
LHC – Large Hadrons Collider
Physical – chemical characteristics of TMAC
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The process of thermo-mechanical activation does not cause changes in the
chemical composition of natural mineral Clinoptilolite (determined by x-ray
analysis performed on samples before and after the activation)

However, thermo-mechanical activation modifies the physical-chemical
properties of natural Clinoptilolite to a significant degree

The most significant changes occur in the:
● particle size,
● active surface,
● electro-static charge and
● ion exchange capacity.

From the results of electrical conductivity measuring it can be concluded that
TMAC has greater ion exchange capacity than non-activated Clinoptilolite.
.
TMA (Thermo-mechanical activation) - is based on process of disintegration of
solid particles with a system of whirling acceleration, controlled friction and
Collisions between particles of materials which are subject of process
Ingredients:
1. Obtain new physical properties
2. Increase of the active surface
3. Increase the absorption, ion exchange and capacity
4. Electron transmission
We can talk about an important change of the energy state of material
Safety of Silica earth/Clinoptilolite
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In the USA the FDA classifies the substance as generally safe in the “Code
of Federal Regulations, Foods and Drugs (FDA), 21 CFR CH.I, §182
Subpart C“
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Since the supplementary oral administration of Silica earth/Clinoptilolite to
humans has already been taking place for 20 years long-term experience in
handling the application of Silica earth/Clinoptilolite to humans per oral can
be assumed.
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In the gastrointestinal sector Silica earth/Clinoptilolite remains stable.
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In the cito-toxicity test there was no biological, toxicological damage to the
test cells.