RESPIRATORY INFECTIONS World Lung Foundation http://www.ariatlas.org/maps?id=0024 World Lung Foundation http://www.ariatlas.org/maps?id=0003 http://www.ariatlas.org/data_research/appendix_b Acute Respiratory Infections http://www.ariatlas.org/data_research/appendix_b Important Viral Causes of Lower Respiratory Infections Influenza Para-influenza Respiratory syncytial virus Adenovirus Human metapneumovirus (2001) common in comprised children and elderly persons No etiologic agent found (33%) Important Bacterial Causes of Lower Respiratory Infections Streptococcus pneumoniae Haemophilus influenzae Staphlococcus aureus No etiologic agent found (33%) Common Risk Factors for Acute Respiratory Infections Poverty Crowding Low parental education Low birth weight Non-breastfeeding of infants Multiple causes and few vaccines RISK FACTORS FOR ACUTE RESPIRATORY INFECTIONS •Smoking – active and passive •Air pollution – indoor and outdoor •Crowding e.g family size, day care centers, refugee camps, poor housing •Malnutrition •Low birth weight •Acute lower respiratory infections @ < 2 years •Socioeconomic status Barriers to Prevention and Control of Lower Respiratory Infections Few vaccines for prevention Difficult to change major risk factors Limited access to appropriate care in areas of highest prevalence No etiologic agent found Cost of pneumococcol, rotavirus, and hemophilus vaccines DIAGNOSIS OF BACTERIAL PATHOGENS IN RESPIRATORY DISEASE Traditional: Culture Antigen detection Recent molecular strategies: Nucleic acid amplification technique (NAAT) DNA microarray:: Streptococcal Chlamydia Coxiella Legionella Pseudomonas Atypical bacteria