Hodgkins Lymphoma – A Cancer in Which 99%
of the Tumor Cells Are Not Cancer Cells
Figure 13.2 The Biology of Cancer (© Garland Science 2007)
Most Tumors Contain a Significant
Fraction of Nontumor Cells
Most tumors are tissues that contain
collaborating communites of tumor and
nontumor cells
The best model for the formation of tumor
tissues comes from studies of wound healing.
In many cases, a solid tumor behaves like a
wound that does not heal.
The Biology of Wound Healing
Platelets enmeshed
in Fibrin clot
Figure 13.14 The Biology of Cancer (© Garland Science 2007)
Figure 13.5b The Biology of Cancer (© Garland Science 2007)
Many Cellular & Molecular Factors Are Involved
in the Process of Wound Healing
Figure 13.10 The Biology of Cancer (© Garland Science 2007)
Signals From Stromal Cells
Figure 13.18a The Biology of Cancer (© Garland Science 2007)
Figure 13.20 The Biology of Cancer (© Garland Science 2007)
Figure 13.19 The Biology of Cancer (© Garland Science 2007)
Angiogeneis & Its Critical Role in Tumor Growth
Early Demonstrations of the Dependence
of Tumors on Angiogenesis
Progressive vascularization of tumor produced by
implanted human colorectal cancer cells in mice.
Adapted from: Principles of Cancer
Biology 2006 By L. J. Kleinsmith
The Angiogenic “Switch” -- A Balance of Factors
Limited Oxygen as Distance to Blood Vessels Increases
However, low O2
promotes activation of
HIF-1 (hypoxia
inducible transcription
factor). The targets of
this gene include key
angiogenesis factors,
PDGF and others.
Figure 13.27d The Biology of Cancer (© Garland Science 2007)
The Von Hippel Landau tumor Suppressor and HIF-1
Figure 7.28a The Biology of Cancer (© Garland Science 2007)
CAFs & Vascularization
ECs & Cappilary
Formation
CAFs in VIVO
Figure 13.22b The Biology of Cancer (© Garland Science 2007)
Endothelial Cells, PDGF, ECM & Pericytes Collaborate
to Form Blood Vessels
Figure 13.6d The Biology of Cancer (© Garland Science 2007)
TAMs & Angiogenesis
MMP-producing Stromal
TAMs in Human
Colorectal Cancer
Figure 13.25c The Biology of Cancer (© Garland Science 2007)
Schematic Overview of TAM Support of Tumor Growth and Survival
Figure 13.26 The Biology of Cancer (© Garland Science 2007)
The Rip-Tag Model
Generation of transgenic mice in which Large T antigen
and Small T antigen are placed under the insulin promoter
yields animals that develop pancreatic tumors that are
restricted to the β-islets.
Figure 13.37 The Biology of Cancer (© Garland Science 2007)
Tumor Vasculature is Less Well Organized Than Normal Vasculature
The neovasculature
of tumors is leaky
In Rip-Tag Mice
Using Intravital Microscopy in Normal Tissue
Figure 13.38b The Biology of Cancer (© Garland Science 2007)
Angiogenesis, Disease Progression and Survival
Figure 13.42b The Biology of Cancer (© Garland Science 2007)
Figure 13.45a The Biology of Cancer (© Garland Science 2007)
Figure 13.47a The Biology of Cancer (© Garland Science 2007)
Figure 13.47c,d The Biology of Cancer (© Garland Science 2007)
Figure 13.47e The Biology of Cancer (© Garland Science 2007)
Figure 13.47f The Biology of Cancer (© Garland Science 2007)
Figure 13.48a, b The Biology of Cancer (© Garland Science 2007)
Figure 13.48c The Biology of Cancer (© Garland Science 2007)
Figure 13.49 The Biology of Cancer (© Garland Science 2007)
Table 13.4 The Biology of Cancer (© Garland Science 2007)
Figure 13.12a The Biology of Cancer (© Garland Science 2007)