SUPERFICIAL MYCOSES Assoc.Prof.Dr.Yesim Gürol Learning Objectives • To list dermatophytes • To list subcutaneous mycoses infections caused by • dermatophytic fungi (dermatophytosis) • Nondermatophytic fungi (dermatomycosis) DERMATOPHYTOSES • Trichophyton • Epidermophyton • Microsporum • cause disease in animals and/or humans. • have the ability to invade the skin,hair or nails. • keratinophylic and keratinolytic. • invade upper outermost layer of epidermis dermatophytosis tineas ringworm Morphology and Identification identified by • colonial appearance • microscopic morphology • Growth at Sabouraud’s dextrose agar at 25oC for two weeks Epidermophyton floccosum Microsporum audouinii Microsporum canis Microsporum persicolor Trichophyton spp. Epidemiology and immunity • Begins in the skin after trauma and contact • Host susceptibility depends on • Moisture • Warmth • Spesific skin chemistry • Composition of sebum and perspiration • Youth • Heavy exposure • Genetic predisposition • Dermatophytes are classified as anthropophilic, zoophilic or geophilic according to their normal habitat. Anthropophilic • human hosts • mild, chronic inflammation. Zoophilic • primarily in animals • inflammatory reactions in humans who have contact with infected cats, dogs, cattle, horses, birds, or other animals. • followed by a rapid termination of the infection Geophilic • from the soil • occasionally infect humans and animals. • They cause a marked inflammatory reaction, which limits the spread of the infection and may lead to a spontaneous cure but may also leave scars. •Contagious • Frequently transmitted by exposure to shed skin scales, nails or hair containinh hyphae or conidia • Tinea capitis • Tinea favosa • Tinea corporis • Tinea pedis • Tinea manuum • Tinea imbricata • Tinea cruris • Tinea barbae • Tinea nigra • Tinea ungium Tinea capitis • infection of the scalp with a dermatophyte fungus. • Hair can be infected with Trichophyton (abbreviated as "T".) and Microsporum ("M".) fungi. classified according to how the fungus invades the hair shaft: Ectothrix infection • The fungal branches (hyphae) and spores (arthroconidia) cover the outside of the hair. • Ectothrix infections can be identified by Woods light (long wave ultraviolet light) examination of the affected area the vet uses this to check your cats fur. Endothrix infection • The hair shaft is filled with fungal branches (hyphae) and spores (arthroconidia). • Endothrix infections do not fluoresce with Woods light. Favus • caused by T. schoenleinii infection • honeycomb destruction of the hair shaft macroconidia When the hair is infected, • ectothrix • endothrix • favic Tinea capitis may present in several ways. • Dry scaling – like dandruff but usually with moth-eaten hair loss • Black dots – the hairs are broken off at the scalp surface, which is scaly • Smooth areas of hair loss • Kerion – very inflamed mass, like an abscess • Favus – yellow crusts and matted hair • Carrier state no symptoms and only mild scaling Trichophytid reaction (id reaction) • The patient may become hypersensitive to constituents or products of the fungus and develop allergic manifestations • Usually vesicles • Mostly on the hands • No fungi present in lesion Tinea capitis Tinea capitis caused by Trichophyton mentagrophytes Tinea barbae Tinea pedis (Athlete’s foot) Tinea corporis Tinea unguium (onychomycosis) Tinea ingualis (cruris) (jock itch) SUBCUTANEOUS MYCOSES • Normally reside in soil or vegetation • Enter the skin or subcutaneous tissue by traumatic inoculation with contaminated material Sporotrichosis Chromoblastomycosis Eumycotic mycetoma Subcutaneous zygomycosis Subcutaneous phaeohyphomycosis SPOROTRICHOSIS • Sporothrix schenkii • Thermally dimorphic • Usually sporadic • Most common in warmer climates • Outbreaks related to forest work, mining, gardening • Classic infection traumatic inoculation of soil or vegetable or organic matter contaminated with fungus • Zoonotic transmission with armadillo hunters and infected cats • Chronic infection • Nodular and ulcerative lesions that develop along lymphatics • grossly may resemble a malignant process ‘squamous cell carcinoma’ • Dissemination to other sites rare !(bones,eyes,lungs, central nervous system) Specimens: • Biopsy • Exudate from lesions • Culture S.schenckii Chromoblastomycosis (chromomycosis) • chronic fungal infection • slow growing verrucous nodules or plaques • mostly in tropics • Pigmented fungi (dematiaceous fungi) Fonsecaea Cladosporium Exophiala Cladophialophora Rhinocladiella Phialophora • into the skin by trauma • Verrucous, wart like lesions • Cauliflower like nodules • Rarely elephanthiasis Subcutaneous phaeohyphomycosis • Darkly pigmented septate hyphae in tissue • Cutaneous and systemic infections • Solitary encapsulated cysts in the subcutaneous tissue • Sinusitis • Brain abscesses (usually fatal) • All exogenous molds that normally exist in nature phaeohyphomycosis • Exophiala, • Phialophora, • Wangiella, • Bipolaris, • Exserohilum, • Cladophialophora , • Phaeoannellomyces, • Aureobasidium, • Cladosporium, • Curvularia • Alternaria MYCETOMA • Local swelling of infected tissue and interconnecting • Often draining • Sinuses or fistulae that contain granules • Actinomycetoma....mycetoma caused by an actinomycete • Eumycetoma....(Madura foot, maduromycosis) mycetoma caused by a fungus • Clinical features similar • Treatment different • Actinomycetomas more invasive MYCETOMA • After traumatic inoculation with soil contaminated with one of these agents • Feet, lower extremities, hands and exposed areas • Suppuration, abscesses, granules, • Contagious muscle and bone • Deformation, loss of function • Very rarely foreign body (e.g.cardiac pacemaker) infection