Dietetic Practice in the Management of Adverse Reactions to Foods Clinical Practice Workshops 2009-2010 Diagnosis of Adverse Reactions to Foods Signs, Symptoms, and Differential Diagnosis The Medical Paradigm • Signs and Symptoms suggest the disease condition • Tests are used to provide a definitive diagnosis and suggest a probable cause • Diagnosis determines the treatment • Treatment typically consists of: – Medications – Surgery – Other appropriate measures 3 Food Allergy and the Medical Paradigm • Food does not cause allergy – The immunological or physiological response to the food is the cause of symptoms • The same food can trigger entirely different symptoms in different individuals, and sometimes different symptoms in the same individual – “One cause, one disease” does not apply 4 Food Allergy and the Medical Paradigm • A specific test will not identify the cause – Most people can eat the allergenic food without symptoms • Food allergy treatment involves medications to control the symptoms – There is no way to stop the allergic reaction once it has started • Prevention involves avoidance of the allergenic food 5 Signs and Symptoms of Food Sensitivities Symptoms vary from individual to individual Sometimes symptoms vary in presentation and severity in the same individual on different occasions • Symptoms appear in all organ systems but tend to be most obvious in: – Skin: • Flushing • Hives • Angioedema (swelling especially of facial areas: lips, throat, tongue) • Itching • Eczema • Rash 6 Signs and Symptoms of Food Sensitivities – Digestive tract: • • • • • • • Stomach ache Abdominal bloating Diarrhea Alternating diarrhea and constipation Nausea Vomiting Heart burn and reflux – Differential diagnosis: Food sensitivity not indicated • Weight loss • Blood in stool 7 Signs and Symptoms of Food Sensitivities – Respiratory tract: • Stuffy nose • Runny nose • Itchy, watery eyes • Difficulty breathing, speaking, or swallowing • Throat tightening • Chest tightening 8 Signs and Symptoms of Food Sensitivities Other organ systems: – Drop in blood pressure – Rapid heart rate – Anxiety; sense of doom – Faintness – Paleness – Loss of consciousness 9 Signs and Symptoms • Anaphylaxis – Involves all organ systems – In rare cases can proceed to cardiovascular collapse – Has the very rare potential to proceed to fatal anaphylactic shock – Management always involves administration of injectable adrenalin (epinephrine) and immediate transportation to emergency medical facilities 10 Epipen and Twinject • How to use injectable epinephrine (adrenalin) – http://foodallergies.about.com/od/emergencytr eatment/ht/autoinjector.htm • Free training kits available: – Epipen 1-877-374-7361 – Twinject 1-877-894-6532 Signs and Symptoms • In babies and children: – Digestive tract distress: • • • • Abdominal pain Spitting up or vomiting Diarrhea May be blood in stool – Irritability – Difficulty sleeping – Failure to thrive – Eczema – Other rashes 12 Diagnosis of Food Hypersensitivity • The symptoms that suggest food sensitivity may actually be caused by many different medical conditions • Frequently the idea of food hypersensitivity is suggested when all other causes for the person’s symptoms have been ruled out • Before food sensitivities are considered, ensure that other causes for the symptoms have been ruled out by appropriate medical investigations 13 Differential Diagnosis • For example: – Celiac disease: high levels of: • anti-tissue transglutaminase antibodies (tTGA) • anti-endomysium antibodies (EMA) – Intestinal infection: stool analysis for: • ova and parasites for parasitic infestations • Clostridium difficile • Other pathogens or potential pathogens – Inborn errors of metabolism 14 Potential Causes of Adverse Reactions to Foods • IgE mediated food hypersensitivity – Food allergy and anaphylaxis – Oral allergy syndrome (OAS) – Latex-food syndrome • Non-IgE mediated food hypersensitivity – – – – – Food protein enteropathies Eosinophilic esophagitis Eosinophilic gastroenteritis Eosinophilic proctocolitis Celiac disease 15 Potential Causes of Adverse Reactions to Foods • Non-immunologically mediated food sensitivity (food intolerances) – – – – – – – Lactose intolerance Sucrose intolerance Fructose intolerance Histamine intolerance Sulphite sensitivity Nickel sensitivity Sensitivity to food additives: • Tartrazine and other azo dyes • Benzoates 16 Treatment of Adverse Reactions to Food • Whatever the physiological basis of the reaction, dietetic management is the same: – Accurate identification of the food components responsible – Avoidance of the offending food ingredient – Provision of a diet that provides complete balanced nutrition from alternative sources – Recognition of the development of tolerance 17 Exercise 1 : Signs and Symptoms Questionnaire 18 IDENTIFYING THE CULPRITS Tests Primary Requirement Accurate Identification of the Culprit Foods • There is a lack of definitive diagnostic tests for food allergies, food intolerances, and other adverse reactions to foods • Skin tests and blood tests detect indicators of probable sensitization to an allergen – usually IgE • They often do not identify the offending food because the mere presence of antibody to the food does not predict the response when the food is consumed 20 TESTS FOR FOOD ALLERGY AND INTOLERANCE • Skin tests: scratch; prick; intradermal Positive response indicated by wheal and flare reaction in the skin Size usually measured 0 - 4+ Indicate release of inflammatory mediators, especially histamine, from skin mast cells Skin mast cells release inflammatory mediators in response to stimuli different from those that trigger mediator release from mast cells in other body tissues - especially the digestive tract 21 Value of Skin Tests in Practice • Positive predictive accuracy of skin tests rarely exceeds 50% (estimates 30% 60%) – Many practitioners rate them lower • Negative tests for some highly allergenic foods thought to have close to 100% predictive accuracy • Such foods include: egg fish tree nuts milk wheat peanut 22 Value of Skin Tests in Practice • Negative skin tests do not rule out the possibility of non-IgE-mediated hypersensitivity reactions • Do not rule out food intolerances (nonimmune-mediated reactions) – “Skin tests for food allergy are especially unreliable because of the large number of false positive and false negative reactions” _________ David 1993 23 Reasons for False Positive Skin Tests • Degranulation of skin mast cells by stimuli that do not degranulate mast cells in the digestive tract • Differences in the form in which the food is applied to the skin compared to that which encounters immune cells in the digestive tract – antigens in fruits and vegetables change when cooked – allergen may be derived from an unstable food extract – digestive processes can unmask antigens 24 False Negative Skin Tests • Children younger than 2-3 years are more likely to have a negative skin test and positive food challenge than adults • Adverse reaction is not mediated by IgE • Commercial allergen may contain no material that the immune system can recognize 25 Blood Tests for Food Allergy – RAST, FAST, ELISA and others Test for the presence of anti-food antibodies Detect anti-food IgE – The mere presence of the antibody does not indicate clinical significance – Positive tests often do not correlate well with observed reactions when the food is eaten 26 Value of Allergy Tests in Practice • A key message is that a positive allergy test result (skin or blood) indicates only the presence of allergen specific IgE (called sensitization) • It does not necessarily mean clinical allergy (ie, allergic symptoms with exposure). • It is important for this reason that the allergy evaluation be based on the patient's history and directed by a health care professional with understanding of allergy ____________ Cox et al 2008 27 Use of the Information Use the information obtained from evaluation of the patient to determine: • which allergy diagnostic tests to order • how to interpret the allergy diagnostic test results • how to use the information obtained from the allergy evaluation to develop an appropriate therapeutic treatment plan. 28 Which Tests Should I Order? • Allergen-specific IgE tests are carried out by a variety of approved methods in Canada • Provincial medical plans usually pay for 5 tests per person per year • Order “food mixes” for the initial five tests • If any are positive the lab will test individual foods within the groups at no additional charge • Do not advise patient to avoid all the foods in the positive mix without further investigation 29 Examples of Blood Tests for allergen-specific IgE • Phadia UniCAP System • This assay system can measure levels of allergen-specific IgE as low as 0.1 kU/L • The clinical relevance of results in the range of 0.1-0.35 kU/L warrants study. 30 Which Tests Should I Order? • Examples of food mixes: – Legume mix (peanuts, soy, beans, lentils) – Vegetable mix – Fruits mix – Grains (includes wheat) – Nut and seed mix – Animal origin foods (milk, egg, meats) – Fish mix – Mollusks and shellfish 31 Example: Grains Code Name Latin name f6 Barley Hordeum vulgare f310 Blue vetch Fabaceae (Leguminosae) f11 Buckwheat Fagopyrum esculentum f55 Common millet Panicum miliaceum f56 Foxtail millet Setaria italica f79 Gluten Common f57 Japanese millet Echinochloa crus-galli f8 Maize/Corn Zea mays f90 Malt Hordeum vulgare f7 Oat Avena sativa f9 Rice Oryza sativa f5 Rye Secale cereale f124 Spelt wheat Triticum spelta f4 Wheat Triticum aestivum 32 Legumes Code Name Latin name f296 Carob bean gum Ceratonia siliqua f309 Chick pea Cicer arietinus f305 Fenugreek Trigonella foenum-graecum f315 Green bean Phaseolus vulgaris f246 Guar, Guar gum Cyamopsis tetragonolobus f297 Gum arabic Acacia spp. f235 Lentil Lens esculenta f182 Lima bean Phaseolus lunatus f12 Pea Pisum sativum f13 Peanut Arachis hypogaea f287 Red kidney bean Phaseolus vulgaris f14 Soybean Glycine max (Soja hispida) f298 Tragacanth gum Astragalus gummifer f15 White bean Phaseolus vulgaris 33 Mollusks Code Name Latin name f346 Abalone Haliotis spp. f37 Blue mussel Mytilus edulis f207 Clam Clam f59 Octopus Octopus vulgaris f290 Oyster Ostrea edulis f58 Pacific Flying Squid Todarodes pacificus f338 Scallop Pecten spp. f314 Snail Helix aspersa f258 Squid Loligo edulis, Loligo vulgaris 34 Milk & constituents Code Name Latin name f78 Casein Bos spp. f81 Cheese, Cheddar type f82 Cheese, mold type f2 Cow's milk Bos spp. f231 Cow's milk, boiled Bos spp. f236 Cow's whey Bos spp. f300 Goat's milk f286 Mare's milk Equus spp. f325 Sheep's milk Ovis spp. f326 Sheep's whey Ovis spp. 35 Testing for IgG4 against foods • Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. • Serological tests for immunoglobulin G4 (IgG4) against foods are persistently promoted for the diagnosis of food-induced hypersensitivity • Many patients believe that their symptoms are related to food ingestion • Tests for food-specific IgG4 represent a growing market • Testing for blood IgG4 against different foods is performed with large-scale screening for hundreds of food items by enzyme-linked immunosorbent assay-type and radioallergosorbent-type assays in young children, adolescents and adults. ______________ Stapel et al 2008 36 Value of IgG4 Tests in Practice • Many serum samples show positive IgG4 results without corresponding clinical symptoms. • IgG4 against foods indicates that the person has been repeatedly exposed to food components, which are recognized as foreign proteins by the immune system • Its presence should not be considered as a factor which induces hypersensitivity, but rather as an indicator for immunological tolerance, linked to the activity of regulatory T cells. ______________ Stapel et al 2008 _______________ Tomicic et al 2009 37 Use of IgG4 Test Results • Food-specific IgG4 does not indicate food allergy or intolerance, but rather a physiological response of the immune system after exposure to food components. • Testing of IgG4 to foods is considered as irrelevant for the laboratory work-up of food allergy or intolerance and should not be performed in case of food-related complaints. ______________ Stapel et al 2008 38 Unorthodox Tests • Many people turn to unorthodox tests when avoidance of foods positive by conventional test methods have been unsuccessful in managing their symptoms • Tests include: – Vega test (electro-acupuncture) – Biokinesiology (muscle strength) – Analysis of hair, urine, saliva – Radionics – ALCAT (lymphocyte cytotoxicity) 39 Disadvantages of Unreliable Tests • • • • • Diagnostic inaccuracy Therapeutic failure False diagnosis of allergy Creation of fictitious disease entities Failure to recognize and treat genuine disease • Inappropriate diets • Malnutrition 40 Consequences of Mismanagement of Adverse Reactions to Foods • Malnutrition; weight loss, due to extensive elimination diets • Food phobia due to fear that “the wrong food” will cause permanent damage, and in extreme cases, death • Frustration and anger with the “medical system” that is perceived as failing them • Disruption of lifestyle, social and family relationships 41 The Bottom Line • Elimination and Challenge is the only accurate method of identifying the specific foods responsible for a person’s adverse reactions • Suspect foods are eliminated from the diet for a specific period of time • Challenge is conducted by reintroducing each eliminated food individually and monitoring the person’s response 42 Identifying the Culprits Elimination and Challenge Elimination and Challenge • Removal of the suspect foods from the diet, followed by reintroduction is the only way to: – identify the culprit food components – confirm the accuracy of any allergy tests • Long-term adherence to a restricted diet should not be advocated without clear identification of the culprit food components 44 Elimination and Challenge Stage 1: Exposure Diary – Record each day, for a minimum of 5-7 days: all foods, beverages, medications, and supplements ingested composition of compound dishes and drinks, including additives in manufactured foods approximate quantities of each the time of consumption 45 Exposure Diary (continued) – all symptoms experienced graded on severity: 1 (mild); 3 (moderate) 2 (mild-moderate) 4 (severe) – time of onset – how long they last • Record status on waking in the morning. • Was sleep disturbed during the night, and if so, was it due to specific symptoms? 46 Exercise 2: Food Record Symptoms Record 47 Food Intolerance: Clinical Diagnosis Elimination Diet: Avoid Suspect Food Increase Restrictions Symptoms Disappear Symptoms Persist Reintroduce Foods Sequentially or Double-blind Symptoms Provoked Diagnosis Confirmed No Symptoms Diagnosis Not Confirmed 48 Elimination Diet Based on: – detailed medical history – analysis of Exposure Diary – any previous allergy tests – foods suspected by the patient • Formulate diet to exclude all suspect allergens and intolerance triggers • Provide excluded nutrients from alternative sources • Duration: Usually four weeks 49 Therapeutic Diets • Certain conditions tend to be associated with specific food components • Suspect food components are those that are probable triggers or mediators of symptoms • Examples: – – – – – Eczema: highly allergenic foods Migraine: biogenic amines Urticaria/angioedema: histamine Chronic diarrhea: disaccharides Asthma: cyclo-oxygenase inhibitors; sulphites 50 Conditions that suggest Specific Food Involvement: Infant eczema – Egg – Milk proteins – Peanut – Soy – Shellfish – Less frequently: • Tomato • Green pea 51 Conditions that suggest Specific Food Involvement: Adult eczema • May start as contact allergy (atopic dermatitis) – Could be indicator of latex allergy • May be symptom of IgE-mediated allergy to any food: – Most common foods as in infant eczema – Less common: tomato; onion • May be exacerbated by foods high in histamine – Include histamine-restricted diet during elimination phase* ______________ *Worm et al 2009 52 Conditions that suggest Specific Food Involvement: Oral Allergy Syndrome (OAS): Foods with allergens similar to birch pollen Fruit Apple Apricot Cherry Kiwi fruit Melon Nectarine Orange Peach Watermelon Vegetables Carrot Celery Fennel Potato Tomato Legumes and Grains Peanuts Nuts and Seeds Hazelnuts Others Spices (unspecified) “Tree nuts” (species unspecified) 53 Latex-Food Syndrome: Foods with allergenic structures similar to latex Fruit and Vegetables Avocado Banana Celery Citrus fruits Eggplant Fig Grapes Kiwi fruit Mango Melon Papaya Passion fruit Peach Potato Pineapple Tomato Legumes and Grains Peanut Soy Wheat Nuts and Seeds Chestnut Pistachio Walnut 54 Foods with Allergens Similar to Latex: PEN Pathway Category Food Type III Clinical findings Identification of cross-reactive allergens Avocado Banana Bell pepper Cassava Celery Cherimoya Chestnut Custard apple Kiwi fruit Mango Papaya Passion fruit Potato Tomato Chestnut Pistachio Walnut Type II Clinical findings Characterization of cross-reactive components by extract inhibition assays Fig Melon Peach Pineapple Turnip Zucchini Type I Clinical findings only Apple Apricot Aubergine (eggplant) Carrot Cherry Coconut Loquat Spinach Strawberry Watermelon Conditions that suggest Specific Food Involvement: Irritable Bowel Syndrome (IBS): Foods most frequently associated with symptoms • Food allergens (individual reactivity) • Intolerance triggers – Disaccharides (e.g. lactose; sucrose) – Monosaccharides (fructose) • Free starches: – White flour; white rice – Root vegetables (potato; carrot) – Starchy fruits (banana) • Raw fruits and vegetables • Processed (fermented) meats and sausages • High level of insoluble fibre (dried peas, beans; bran from grains; whole nuts and seeds) • “Irritant” spices 56 Conditions that suggest Specific Food Involvement: Eosinophilic gastroenteritis: Abnormal number of eosinophils in the stomach and small intestine Foods most frequently implicated • • • • Egg Cow’s milk Soy Wheat • • • • Peanuts Tree nuts Shellfish Fish 57 Conditions that suggest Specific Food Involvement: Eosinophilic esophagitis: Abnormal number of eosinophils in the esophagus Foods most frequently implicated • Egg • Cow’s milk • Soy • Wheat • Corn • Peanuts • Tree nuts • Shellfish • Fish • Beef • Rye Conditions that suggest Specific Food Involvement: Eosinophilic proctocolitis: Abnormal number of Eosinophils confined to the colon Foods most frequently implicated • • Cow’s milk Soy proteins Most frequently develops within the first 60 days of life Is a non-IgE-mediated condition Conditions that suggest Specific Food Involvement: Celiac disease (gluten-sensitive enteropathy) Offending Foods and their derivatives • Wheat • Rye • Barley • And in some cases Oats 60 Conditions that suggest Specific Food Involvement: Histamine intolerance: Histamine-containing and Histamine-releasing foods Animal Proteins Eggs Shellfish Fish (unless freshly caught) Processed and fermented meats and sausages Left-over meats Milk Products Fermented milk products: Cheese of all types Yogurt Buttermilk Kefir Fruit Vegetable Additives Citrus fruits Berries Raisins Cherries Apricots Pineapple Prunes Dates Currants Grapes Tomato Spinach Eggplant Pumpkin Soy Red beans Olives Avocado Tartrazine Benzoates Sulphites Other Cinnamon Cloves Anise Nutmeg Vinegar Tea Chocolate Colas Alcoholic and dealcoholise beverages 61 Basic Hypoallergenic Elimination Diet • Only listed foods are allowed • No vitamin supplements or non-essential medications • GRAINS: • FRUITS: • VEGETABLES: • MEAT: Rice Tapioca Pears; pear juice Cranberries; cranberry juice Squash (all varieties) Carrots Parsnips Lettuce Lamb Wild game Turkey 62 Basic Hypoallergenic Elimination Diet • MEAT SUBSTITUTES: Lentils Split pea Garbanzo beans (chick peas) • FLAVOURINGS: Sea salt • BEVERAGES: Distilled water in glass containers • OILS Canola oil Olive oil Safflower oil • OTHER Agar-agar (Make jelly dessert s) 63 Exercise 3: Determining the Appropriate Elimination Diet 64 Duration of the Elimination Diet • The “Basic Hypoallergenic (few foods) Diet” is nutritionally inadequate and should not be followed for longer than 10 to 14 days • A selective elimination diet with nutritionally equivalent substitutes is followed for four weeks – Four weeks seems to be optimum for remission of symptoms and for elicitation of symptoms on challenge 65 Expected Results of Elimination Diet • Symptoms often worsen on days 24 of elimination • By day 5-7 symptomatic improvement is experienced • Symptoms disappear after 10-14 days of exclusion 66 Challenge • Use incremental dose challenge (SIDC) to each eliminated food in its purest form to determine: – immediate reaction – delayed reaction – degree of tolerance (dosage) • Do not test any food suspected to have caused a severe or an anaphylactic reaction except under medical supervision in a facility equipped for resuscitation 67 Food Challenge Record: Seattle Lab Metabisulfite Table 1 Schedule Dose Number 1 2 3 4 5 6 7 Amount (mg) 0.1 0.5 1.0 5.0 10.0 15.0 25 Dose Number 8 9 10 11 12 13 Amount (mg) Placebo 50 75 100 150 200 68 Table 2 Results Challenge dose in gelatin capsule administered every 10 minutes Time Blood Pressure Dose (mg) Effects Reported 9.00 100/58 0.1 Patient feels good 9.10 110/73 0.5 No reaction 9.25 112/71 1.0 No reaction 9.35 118/81 5.0 Itching eyes Plugged ears 9.45 103/81 10 Plugged ears 9.55 118/83 15 No reaction 10.05 103/69 25 Chest tightness 10.20 108/76 Placebo Tingling around mouth 10.30 110/80 50 Patient feels good No reactions 10.45 107/72 75 Patient feels good No reactions 10.55 107/72 100 No reactions 11.10 114/75 150 Numbness of upper lip and tongue 11.25 114/75 200 Patient feels good No significant numbness of upper lip Spirometric measurements for pulmonary function performed during and after all challenges were normal: No breathing impairment Conclusions: Reaction to bisulfite is ruled out 69 Challenge • The basic elimination diet, or therapeutic diet, continues during this phase • For adults: – Do not add any test foods to the diet until all eliminated foods have been tested separately, even if they produce no reaction during the challenge • Children: – Add foods causing no adverse reaction when all tests in a single food category have been tested (e.g. add milk when all tests in the “milk category” have been completed) 70 Incremental Dose Challenge Day 1: • Morning: Eat a small quantity of the test food Wait four hours, monitoring for adverse reaction; if no symptoms: • Afternoon: Eat double the quantity of test food eaten in the morning. • Wait four hours, monitoring for any adverse reactions; if no symptoms: • Evening: Eat double the quantity of test food eaten in the afternoon 71 Incremental Dose Challenge Day 2: • Do not eat any of the test food – Continue to eat elimination diet • Monitor for any adverse reactions during the night and day. This may be due to a delayed reaction to the test food • If an adverse reaction to the test food occurs at any time during the test: STOP. – Do not continue to eat the test food • Wait 48 hours after all symptoms have subsided before testing another food 72 Incremental Dose Challenge Day 3: • If no adverse reactions have been experienced proceed to a new food • If the results of Day 1 and/or Day 2 are unclear : – Repeat Day 1, using the same food, the same test protocol, but larger doses of the test food • Day 4: – Monitor for delayed reactions as on Day 2 73 Challenge Test • Continue testing in the same manner until all excluded foods, beverages, and additives have been tested • The first day is the test day and the second is a monitoring day for delayed reactions 74 Maintenance Diets The Essentials in Providing Complete Balanced Nutrition DIET FOR OPTIMUM NUTRITION Provide a nutritionally balanced diet that supplies all essential macronutrients (protein, fat, carbohydrate) and micronutrients (vitamins and minerals) every day Diets restricted because of food sensitivities: • Each meal and snack should contain three components: 1. Protein (PRO) 2. Grain (GR) or Starch (ST) 3. Fruit and/or Vegetable (FR/VEG) 76 Examples of Foods in Each Major Food Category: Protein • • • • • • • • • Meat of all types Poultry Fish Shellfish Eggs Nuts Seeds Tofu Milk – – – – Milk products such as: Cheese of all types Yogurt Buttermilk 77 Examples of Foods in Each Major Food Category: Grains • • • • • • • • • • • Wheat Rye Oats Barley Rice Corn Amaranth Quinoa Buckwheat Millet Varieties and derivatives of wheat, such as: – – – – – Spelt Kamut Bulgur Triticale Semolina 78 Examples of Foods in Each Major Food Category: Starches • • • • • • • • • • • • • • • Flours and starches derived from “Grains” Starchy vegetables and fruits, such as: Potato Sweet potato Yam High-starch root vegetables Lentils Dried beans Dried peas Garbanzo bean (chick pea) Lima beans Broad beans (fava) Cassava Plantain Banana 79 Examples of Foods in Each Major Food Category: Fruit Berries: Strawberry Raspberry Blueberry Cranberry Blackberry Others Stone fruits: Peaches Apricot Nectarines Cherries Plums Others Melons: Cantaloupe Honeydew Watermelon Others Apple Pear Rhubarb Grape Citrus Fruits: Orange Grapefruit Lemon Lime Tropical fruits: Pineapple Mango Papaya Passion fruit Lychee Longon Star fruit Dragon fruit 80 Examples of Foods in Each Major Food Category: Vegetables Green leafy vegetables, e.g.: Green, red, yellow peppers Lettuce Squashes of all types Chard Onions Spinach Garlic Broccoli Tomatoes Beans: Carrots Green Beets String French Radishes Runner Cauliflower Yellow wax Asparagus Peas Eggplant Green peas Sugar peas 81 IMPORTANT NUTRIENTS IN COMMON ALLERGENS Vitamins M I L K E G G A + + Biotin + + Folacin (Folate; Folic acid) + + B1 (Thiamin) B2 (Riboflavin) + B3 (Niacin) B5 (Pantothenic acid) + B6 (Pyridoxine) B12 (Cobalamine) P E A N U T S O Y F I S H W H E A T R I C E C O R N + + + + + + + + + + + + + + + + + + + + D + + + E (alpha-tocopherol) + + K + + + + + + + + + C + + + 82 IMPORTANT NUTRIENTS IN COMMON ALLERGENS Minerals M I L K Calcium + Phosphorus + E G G P E A N U T S O Y + F I S H W H E A T + + + + + + Iron + + + Zinc + + + + + + + + Magnesium Selenium Potassium + + + Molybdenum Manganese C O R N + + + + Chromium Copper R I C E + + + + + 83 Invitation to Further Information www.allergynutrition.com Joneja, J.M.Vickerstaff Dealing with Food Allergies Bull Publishing Company, Boulder, Colorado. 2004 84