Reproductive System Diseases General Information • The function of sexuality – reproduction and enhancement of caring and pleasure World Health Organization Components of Sexual Health • The enjoyment and control of sexual and reproductive behavior according to personal and social ethics • Freedom from fear, shame, guilt and psychological factors that impair sexual relationships • Freedom from organic disorders, diseases and deficiencies that may interfere with either sexual or reproductive functions Stages of sexual response cycle • • • • • Arousal - psychological Plateau - psycho and physiological Orgasm - psycho and physiological Resolution - psycho and physiological Also includes vasoconstriction and myotonia which may arise if some physical or mental condition arises Sexual Dysfunction • An important consideration in the treatment of sexual dysfunction is a sensitivity to open communication about the problem • Physicians need to include detailed sexual history as part of medical history • Total health care must include human sexual response and its function or dysfunction Dyspareunia (Painful Intercourse) • Dysparneunia is the occurrence of pain in women during sexual intercourse Etiology • Anatomic – deformities of lesions in vagina, an intact hymen, or retroversion of uterus • Pathological – Scar tissue, genitourinary tract infections, pelvic inflammatory disease, abnormal growths, endometriosis, or allergic reactions to contraceptive material • Psychosomatic – Fear of pain, feelings of guilt or shame, lack of arousal, fear of pregnancy Signs and Symptoms • Mild to severe discomfort during or after intercourse • Vaginal itching or burning Diagnostic Procedures • Physical examination • Detailed sexual history Treatment • Creams or water-soluble jellies for lubrication prior to intercourse • Excision of scars • Genital stretching • Education Prognosis • Good with adequate treatment, proper education and sensitivity from partner Prevention • Prompt treatment of any infections Erectile Dysfunction • Erectile dysfunction is the inability of the man to achieve or sustain an erection sufficient to complete sexual intercourse Etiology • Psychological causes include anxiety, depression or feelings of inadequacy • Physiological causes include pharmological agents, drug and alcohol abuse, diabetes mellitus, surgical complications, spinal cord and disk injuries, and neurological, endocrine, or urologic disorders Signs and Symptoms • Partial – unable to achieve full • Intermittent – sometimes potent • Selective – only with certain women Diagnostic Procedures • Differentiate between psychological and physiological causes of impotence • Physical examination • Medical history review • Detailed sexual history Treatment • • • • Therapy Counseling Surgical implantation of prosthesis Drug sildenafil (Viagra) – enhances the effects of nitric oxide, which is released into penis during sexual arousal, allowing increased blood flow Prognosis • Variable – depends on duration and severity • Viagra should only be taken while in physician’s care Arousal and Orgasmic Dysfunction in Women • Orgasmic dysfunction is the inability to achieve orgasm • Arousal dysfunction is the lack of desire for sexual activity and arousal Etiology • Diseases that produce nerve damage, such as diabetes mellitus or multiple sclerosis • Drug reactions, pelvic infections, and vascular diseases • Anxiety, depression, stress and fatigue, inadequate or ineffective stimulation, or early traumatic experiences Signs and Symptoms • Loss of sexual desire or slow sexual arousal • Lack of vaginal lubrication or vasocongestive response • Inability to achieve orgasm totally or under certain circumstances Diagnostic Procedures • Physical examination • Medical history • Detailed sexual history Treatment • Sex therapy • Eliminate involuntary inhibitions of orgasmic reflex • Experimental therapy • Psychoanalysis • Behavior modication Prognosis • Good is no nerve damage • Psychological causes may require lengthy treatment Premature Ejaculation • Premature ejaculation is the expulsion of seminal fluid prior to complete erection of the penis or immediately following the beginning of sexual intercourse Etiology • • • • Anxiety Guilt Negative sexual relationships Pathological factors are rare, but may be linked to degenerative neurological disorders, urethritis, prostatis Signs and Symptoms • Ejaculation during foreplay • Prior to complete erection • As soon as intromission Diagnostic Procedures • Physical examination • Laboratory tests • Detailed sexual history Treatment • Sex therapy • Partners learning techniques to prevent premature ejaculation • Understand condition is reversible Prognosis • Excellent with proper treatment and understanding from both partners • Positive self image Prevention • No prevention is known Male and Female Infertility • Infertility is diagnosed as failure to become pregnant after 1 year of regular, unprotected intercourse • 10 percent of couples are infertile • Female fertility peaks at 24 and diminishes at 30, pregnancy is rare after 50 • Most fertile within 24 hours of ovulation • Male fetility peaks at 24 and declines at 40 • Greatest fertility occurs with sex 4 times per week Etiology • Women – hormonal, nutritional deficiencies, infections, tumors, anomalies • Men – sperm deficiencies, congenital abnormalities, endocrine imbalance, chronic inflammation of testes, epididymis, vas deferens Signs and Symptoms • Typically no sexual dysfunction • Inability to conceive Diagnostic Procedures • Women – complete medical, surgical and gynecologic history and examination • Serology test for syphilis • Hysterosalpingography • Analysis of cervical mucus after coitus – Huhner test • Men – sexual abstinence for 4 days and then complete ejaculation and sperm count • Testicular biopsy if azoospermia or oliospermia is determined Treatment • Women – salpingostomy, Removal of ovarian abnormalities, alleviation of cervicitis, hormone therapy • Men – correction of testicular hypofunction secondary to hypothyroidism, Surgical correction of varicocele or hydrocele, hormone therapy Prognosis • About 50 percent of couples who are treated for infertility achieve pregnancy • Rest are untreatable and complicated Prevention • Avoid causative factors such as infections, drugs and alcohol, trauma, and environmental agents • Need emotional support and information Gonorrhea • Gonorrhea is a contagious bacterial infection of the epithelial surfaces of the genitourinary tract for men and women. • Currently one of the most prevalent sexually transmitted (venereal) diseases in the U.S. Etiology • Caused by the bacterium Neisseria gonorrhoeae • Infants born of infected mothers can get gonorrhea during vaginal delivery and may infect the conjunctivae, respiratory tract, or anal canal Signs and Symptoms • Many cases, especially women, are asymptomatic or produce only symptoms so slight that they are ignored • Infected men show signs of acute urethritis, purulent urethral discharge, dysuria, and urinary frequency. • Discharge from pharynx or rectum with pain among homosexuals Diagnostic Procedures • Bacterial cultures Treatment • Antibiotics, including penicillin or tetracycline • Clients should have 2nd culture in 1 to 2 weeks and the 6 months Prognosis • Good • Systemic gonorrheal infections may produce joint destruction or potentially lifethreatening complications such as meningitis, or endocarditis • Pelvic inflammatory disease among women Prevention • • • • Condoms Avoid multiple partners Trace sexual contact with infected persons 1 percent silver nitrate solution in eyes of newborns reduce gonococcal ophthalmia neonatorum Genital Herpes • Genital, or venereal, herpes is a highly contagious viral infection of the male and female genitalia • Unlike others, herpes recurs spontaneously • Two stages – Active – skin lesions – Latent - asymptomatic Etiology • • • • • Caused by herpes simplex virus (HSV) Two strains – HSV-1 and HSV-2 HSV-2 causes most Direct contact with bodily secretions Infections occur during sexual intecourse, oral-genital sexual activity, kissing, handto-body contact Signs and Symptoms • Skin lesions on genitals, mouth, and/or anus • Shallow ulcerations, pustules, or erythmatous vesicles • Acute pain and itching • Fever, headache, malaise, muscle pain, anorexia, dysuria • Leukorrhea in women Diagnostic Procedures • Physical examination • Scraping and biopsy of ulceration Treatment • Topical medications to reduce edema • Clean and dry • Antiviral drugs - acyclovir Prognosis • Genital herpes cannot be cured • 80 percent of individuals will experience a recurrence within 12 months • May produce cervical cancer Prevention • No proven method of prevention • Avoid sexual intercourse with infected individuals • Condoms • Cesarean birth Genital Warts • Genital warts are circumscribed, elevated skin lesions near genitalia or anus • Papillomas have fibrous tissue outgrowth Etiology • Papillomaviruses • Spread during intimate sexual contact • Incubation period of 6 months Signs and Symptoms • • • • • Asymptomatic or tenderness in area End of penis Perianal area Opening of vagina Warts are 3 to 4 inches in diameter Diagnostic Procedures • Scrapings from wart cells are diagnosed Treatment • • • • Topical medication Cryosurgery Electrocautery Debribement Prognosis • Spontaneous “cures” are rare • Some are unresponsive Prevention • Avoid sexual intercourse with infected individuals and regularly washing genitalia area Syphilis • Syphilis is a highly infectious, chronic, sexually transmitted disease characterized by lesions that may involve any organ or tissue Etiology • Bacterium Treponema pallidum • Direct contact with infected lesions • Sexual intercourse or contact with bodily fluids • Transfusion of blood • T. pallidum may cross placenta and infect fetus, causing serious fetal damage • Spread to lymphatic system and blood Signs and Symptoms • Three stages if left untreated – Primary syphilis – 3 wks incubation, appearance of distinctive, painless lesions, called a chancre, appears on penis or anus or labia of vagina, cervix, lips, tongue, fingers, accompanied by lymphadenopathy – highly contagious Signs and Symptoms • Secondary syphilis – rash with uniform macular, papular, pustular or nodular lesions on soles or palms • Lesions erode and become contagious • Headache, malaise, gastrointestinal upset, sore throat, fever, alopecia, and brittle nails Signs and Symptoms • Latent syphilis – begins asymptomatic • Final or tertiary stage appears 2 to 7 years later and may cause damage to aorta of heart, central nervous system, or musculoskeletal system Diagnostic Procedures • Fluorescent treponemal antibody-absorption (FTA-ABS) test • Venereal Disease Research Lab (VDRL) and cerebrospinal fluid (CSF) examination Treatment • Penicillin, intramuscularly • Tetracycline or erythromycin may be used if allergic to penicillin Prognosis • Varies • Any organ damage is irreversible • Poor for fetus Prevention • Condoms Trichomoniasis • Trichomoniasis is a protozoal infestation of the vagina, urethra, or prostate. Etiology • Affects 10 to 15 percent of sexually active persons • Increased susceptibility to Trichomonas infection by using vaginal sprays and overthe-counter douches • May change natural flora of vagina Signs and Symptoms • 50% of women are asymptomatic for 6 mths • Acute vaginitis – a strong smelling, greenish yellow, frothy vaginal discharge, accompanied by itching, swelling, dyspareunia, and dysuria • May persist for months if untreated Diagnostic Procedures • Microscopic examination of seminal or vaginal discharge • Urinalysis Treatment • Antiparasitic drugs • Should have follow-up examination Prognosis • Good with proper treatment • Re-infection may occur Prevention • Over-the-counter douches and vaginal sprays should be avoided • Abstinence • Condoms • Wear cotton or loose-fitting underwear • Cleanliness Chlamydial Infections • Sexually transmitted that causes inflammation of urethra and epidymis in men and inflammation of cervix in women • Most potentially damaging of all STD’s Etiology • Silent STD • Resembles gonorrhea in may women • Itching and burning, vaginal discharge, and cervicitis • Urethritis and epididymitis may result Diagnostic Procedures • Cytological and serological studies reveal C. trachomatis in infected body fluids Treatment • Tetracycline and erythromycin • Both partners must be treated simultaneously Prognosis • If untreated, disease in fallopian tubes, pelvic inflammation, infertility in women • Men may suffer epididymitis and become sterile Prevention • Condoms Prostatitis • Inflammation of prostate gland • Acute or chronic • Common in men over 50 Etiology • Bacterial or non-bacterial • Causes – E. coli – Klebsiella – Streptococcus • May be in urethra or bloodstream Signs and Symptoms • Low back pain, myalgia, perineal fullness, urinary frequency and urgency • Prostate may be enlarged, tender, and boggy Diagnostic Procedures • Abnormally high leukocyte counts in the absence of detectable bacteria Treatment • Rest and increased fluid intake • Analgesics, antipyretics, and stool softeners • Stitz baths Prognosis • • • • Acute prostatitis responds well to treatment Chronic prostatitis does not Cystitis Urethritis Prevention • Early treatment of urinary tract infections Epididymitis • Inflammation of the epididymis due to infection • Unilateral condition • Most common infections of male reproductive system Etiology • Chlamydia trachomatis and Neisseria gonorrhea • E. coli, Staphylococcus and Streptococcus • Can occur as result of prostatits, urinary tract infection, mumps, tuberculosis, or gonorrhea and syphilis Signs and Symptoms • Epididymis may become enlarged, hard, tender, causing pain • Scrotal and groin tenderness • Fever • Patients may waddle as they walk Diagnostic Procedures • Urinalysis • Urine cultures • Increased leukocyte count Treatment • Antimicrobial therapy • Scrotal support • analgesics Prognosis • Inflammation responds well • Sterility may result if treatment is delayed • Orchitis may develop Prevention • Inflammation of testes due to infection and is a serious complication of epididymis • Condition may be unilateral or bilateral Etiology • May arise from mumps virus • Scrotal trauma Orchitis Signs and Symptoms • • • • • • Testicular swelling Acute pain Chills Fever Malaise Nausea and vomiting Diagnostic Procedures • Testicular examination Treatment • Analgesics • Antipyretics • Scrotal support Prognosis • Good • Atrophy of affected testicle • Sterile Prevention • Mumps vaccine Benign Prostatic Hyperplasia • Overproliferation of cells within inner portion of prostate • Common in men over 50 Etiology • Metabolic and hormonal changes associated with aging • Enlarged prostate may press against rectum, causing constipation Signs and Symptoms • Urinary obstruction • Difficulty in initiating urination or incomplete emptying of bladder • Dysuria, nocturia, dribbling, urinary frequency, weak urine • Hydronephrosis or pyelonephritis Diagnostic Procedures • Rectal examination • IVP – intravenous pyelogram • Prostatic biopsy to ensure that prostatic carcinoma is not causing enlargement Treatment • Prostatic massage, catherization, stitz baths • Medications to shrink prostate • Transurethral thermo-ablation therapy (T3) Prognosis • Good with proper intervention • If untreated, infections ma ascend to kidney Prevention • none Prostatic Cancer • • • • • Malignant neoplasm of prostate tissue Classified as adenocarcinomas 3rd leading cause of cancer deaths in men Tends to metastasize and spreading to bones Rare before age 50 Etiology • Cause is not known • Increased incidence with age Signs and Symptoms • • • • • Asymptomatic Dysuria Difficulty in voiding Urinary frequency Urinary retention Diagnostic Procedures • CT scan • Prostate-specific antigen (PSA) blood test Treatment • • • • Surgery Orchidectomy and estrogen therapy Radiation therapy Chemotherapy Prognosis • Earlier the cancer is detected, the better • Survival rates 50 to 76 percent Testicular Cancer • Malignant neoplasm of testis • Affects young to middle-aged men Etiology • Cause is unknown • Predisposing factors such as cryptorchidism • History of mumps or inguinal hernia during childhood Signs and Symptoms • Smooth, firm, painless mass in testicles • Later symptoms may include breast enlargement or nipple tenderness Diagnostic Procedures • Palpatation of testes • CT scan • MRI Treatment • Surgery • Radiation • Chemotherapy Prognosis • Cure rates of 90 percent Prevention • Early detection is crucial to successful treatment • Perform monthly testicular examinations Female Productive Diseases Premenstrual Syndrome (PMS) • A cluster of symptoms that regularly occur several days prior to onset of menstruation • More frequently in thirties and forties Etiology • Cause is not clearly understood • Attributable to water retention, estrogen – progesterone imbalance, psychological factors or dietary deficiencies Signs and Symptoms • • • • • • • Irritability Sleeplessness Fatigue Depression Headaches Vertigo Abdominal bloating or weight gain Diagnostic Procedures • Keep a journal recording • Evaluation of estrogen and progesterone levels • Blood tests to rule out anemia Treatment • A reduction of salt intake for 2 weeks prior to menses to minimize water retention • Avoid coffee, nicotine, and alcohol • Proper diet and exercise and rest • Reduction of stress and relaxation techniques Prognosis • Variable Prevention • No known prevention Amenorrhea • Absence of menarche beyond age 16 or absence of menstruation for 6 months Etiology • Hormonal imbalance capable of preventing ovulation • Absence of uterus • Endometrial problems, ovarian or pituitary tumors, malnutrition, psychological stress, or too much physical exercise Signs and Symptoms • Delayed menarche for youth • Absence of menstruation in adults Diagnostic Procedures • Pelvic exam to rule out pregnancy or anatomic abnormalities • Blood and urine samples • X-rays or laparoscopy Treatment • Hormone therapy • surgery Prognosis • Good Prevention • Adequate diet • Reduction of psychological stress • Balanced exercise Dysmenorrhea • Pain associated with menstruation • Frequently gynecologic disorders • Two categories – Primary – no identifiable pathological disorders – Secondary – underlying disease condition Etiology • Hormonal imbalance such as prostaglandin • Endometriosis, cervical stenosis, or pelvic inflammatory disease • Uterine polyps or benign tumors Signs and Symptoms • Sharp, cramping pains • Starts prior to menses • Subside within 18 to 24 hours Diagnostic Procedures • Laparoscopy and dilation and curettage (D&C) may be attempted Treatment • Analgesics and non steroid antiinflammatory drugs • Heat • Uterine leiomyomas may require surgery Prognosis • Good Prevention • Correction of hormonal imbalance Ovarian Cysts and Tumors • Derived from ovarian follicles and corpus luteum • Nonneoplastic cysts (tumors) are small • Neoplasms may be benign, malignant, cystic, or solid • Tissues colors change Etiology • Not known Signs and Symptoms • Pelvic pain • Lower back pain • dyspareunia Diagnostic Procedures • Laparoscopy • Sonography Treatment • Surgery only if malignant Prognosis • varies Prevention • No known prevention Endometriosis • Appearance and growth of endometrial tissue in areas outside endometrium, the uterine cavity’s lining • Misplaced endometrial tisse in pelvic area Etiology • Cause is not known Signs and Symptoms • Dysmenorrhea occurs, with pain in lower back and vagina Diagnostic Procedures • Laparoscopy Treatment • Hormone therapy • Surgery to include uterus, cervix, ovaries, and fallopian tubes Prognosis • Varies • Primary complication is infertility Prevention • Use sanitary napkins rather than tampons Uterine Leimyomas • Often mislabeled as fibroids or fibroid tumors • Smooth muscle tissue • Tend to calcify after menopause Etiology • Stimulated by estrogen Signs and Symptoms • Pelvic pressure, urinary frequency, constipation and meorrhagia Diagnostic Procedures • Ultrasonography and D & C Treatment • Dependent on age, parity, desire to have children • Tumor status • Surgical removal of tumors Prognosis • good Pelvic Inflammatory Disease • Acute, or subacute, or a recurrent or chronic infection of the fallopian tubes, ovaries, and adjacent tissues Etiology • Parturition • Infections from N. gonorrhoeae, C. trachomatis, Pseudomonas, and E. coli • Iatrogenic • Conization • Most common in young nulliparous women Signs and Symptoms • Sudden pelvic pain • Purulent and foul-smelling vaginal discharge • Fever • Sexual dysfunction Diagnostic Procedures • Ultrasonography used to identify a uterine mass Treatment • Antibiotics • Surgery may be necessary to prevent septicemia Prognosis • Good when treated early Menopause • The cessation of menses and ovarian function • Decrease in estrogen levels • Not a disease Etiology • Occurs naturally in women between ages 40 and 50 Signs and Symptoms • • • • • • • Menstrual irregularities Decrease in flow Hot flashes Night sweats Tachycardia Loss of elasticity in skin Reduction in size and firmness of breast Diagnostic Procedures • Blood serum levels checked for increased production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) Treatment • Hormonal replacement therapy if needed Prognosis • Good Prevention • Cannot be prevented but emotional swings occur Diseases of the Breasts Mammary Dysplasia or Fibrocystic Disease • Generalized diagnosis of palpable lumps or cysts in breasts • Papillomatosis • Fibrosis • Hyperplasia • Chronic cystic mastitis • More frequently in women 30 to 50 Signs and Symptoms • • • • The upper, outer quadrant of the breast Widespread lumpiness Localized mass Pain, tenderness, and nipple discharge Treatment • Caffeine intake may be restricted Prognosis • Good • Cancer is more common in women who also have mammary dysplasia Benign Fibroadenoma • Benign, well-circumscribed tumor • Occurs usually 20 years after puberty Signs and Symptoms • Round, firm, discrete, and relatively movable • nontender Prognosis • Good Carcinoma of Breast • Encompasses a variety of malignant neoplams • Most common site of cancer in women • Replaced by lung cancer as number 1 Etiology • Hereditary patterns • Greatest risk in women over 40 who have not had children or until after age 35 Signs and Symptoms • • • • • • Lump Thickening Dimpling Swelling Distortion Retraction or scaliness edema redness nodularity ulceration Diagnostic Procedures • Monthly self-examination • Mammography • ultrasonography Treatment • • • • • • Curative or palliative Total mastectomy Lumpectomy Radiation to shrink tumors Breast reconstruction Hormone receptors Prognosis • Depends on stage of cancer • 5-year survival rate for localized breast has risen to 97 percent • If spread regionally, 76 percent survival rate Disorders of Pregnancy and Delivery Spontaneous Abortion • Also called miscarriage, and is the expulsion of the conceptus before viability Signs and Symptoms • Pink or brown discharge may precede onset of cramping and increased vaginal bleeding • Clotty menstrual flow • Pulse rate increased • Blood pressure is lowered Ectopic Pregnancy • Occurs when the fertilized ovum implants and grows somewhere other than the uterine cavity • Most common in fallopian tubes Etiology • Scarring or inflammation of the fallopian tubes as result of infection or congenital malformations Signs and Symptoms • Abdominal pain and tenderness • If life threatening, severe abdominal pain Treatment • Laparotomy • Transfusions of blood in the event of severe intra-abdominal bleedding or hypovolemic shock Toxemias of Pregnancy • Hypersensitive disorder that may develop during the third trimester. • Preeclampsia – edema or proteinuria • Eclampsia – convulsions or coma Etiology • Related to malnutrition, especially lack of protein Signs and Symptoms • • • • Sudden weight gain High sodium ingestion may contribute Headaches, vertigo, malaise, irritability Egigastric pain and nausea Treatment • Goal is prevent eclampsia and to deliver a normal baby • Bed rest is advised • Sedatives • Antihypertensives Prognosis • Good • In eclampsia, maternal mortality rate is 15 percent Placenta Previa • Placenta is implanted abnormally low in the uterus so that it covers all or part of the internal cervical os, or opening • Dangerous because placenta may prematurely separate from uterus Etiology • Predisposing factors – Multiparity – Advanced maternal age – Uterine surgery Signs and Symptoms • Slight, painless bleeding • Ok as long as fetal heart tones remain strong Prognosis • Depends on amount of bleeding • Age • Blood loss Abruptio Placentae • Premature separation of a normally implanted placenta from the uterine wall about the 20th week of gestation • Most common condition is multigravidae Etiology • • • • Trauma Chronic hypertension Preeclampsia eclampsia Signs and Symptoms • Sudden, severe abdominal pain with boardlike rigidity, tenderness of the uterus, hemorrhage and the onset of shock Prognosis • Good if bleeding is controlled • Complications of blood loss include disseminated intravascular coagulation (DIC) and renal failure Premature Labor/ Premature Rupture of Membranes (PROM) • Early rupture of amniotic sac • Early onset of rhythmic uterine contractions Etiology • Incompetent cervix • Multiple pregnancy • Infections Signs and Symptoms • Blood-tinged flow from the vagina • effacement Common Disorders of Pregnancy and Delivery • Abdominal pain, tenderness or cramping • Unusual discharge, pink or brown in color, or clotted • Hypertension, rapid weight gain, edema, and malaise, which indicates possible toxemia