By Johnny Arcus
Definition
 F.O.P is a progressive disease. It becomes more severe
as time goes on
 It is a disease that turns muscle, tendons, and
ligaments into bone in a process called ossification
 Bridges of extra bone develop across joints,
progressively restricting movement and forming a
second skeleton that imprisons the body in bone
Symptoms
 Malformed big toes- the big toe is usually shorter than
normal and turned outward abnormally
 Excessive bone growth- painful tumor like swelling
visible on the neck, shoulders, and back
 Breathing problems, difficulty speaking or eating,
limited mobility, and skin sores.
How common is it?
 Occurs in all countries of the world
 One in every two million
 Both men and women are affected equally
 No ethinic, racial, or gender patterns
Causes
 Genetic mutation
 Random occurrence- occurs during the development of
the egg, sperm, or embryo
 Short thumbs, pinkie clinodactly curve toward the
thumb
 Malformed cervical, vertebrae, short broad neck of the
femur
 Deafness, scalp baldness, and mild retardation
Treatments
 There is no treatment
 Pain medication are prescribed to the patients
Facts
 One of the rarest, most disabling genetic conditions
 Movement in areas affected are the neck, spine, chest,
shoulders, elbows, wrists, hips, knees, ankles, and jaw
 People with F.O.P experience different rates of bone
formation; for some it can be very rapid, for others it
could take awhile for a flare up to happen
 The most common starting sites of FOP disease are the
neck and the shoulder girdle
 FOP is genetically a dominant trait
Sources
 http://www.ifopa.org/en/what-is-fop/overview.html
 http://www.wellness.com/reference/conditions/fibrodyspla
sia-ossificans-progressiva-fop/symptoms-and-causes
 http://www.ucsfbenioffchildrens.org/conditions/fibrodyspla
sia_ossificans_progressiva/
 http://www.disabled-world.com/disability/types/fop.php
 http://www.medterms.com/script/main/art.asp?articlekey=
12442