Dentinoma: a case report
G.Margiotta*, T. Cutilli**, AR Vitale*, G. Coletti***, P. Leocata*.
*Dept of Surgical Pathology, University of L’Aquila, L’Aquila, Italy** Dept of
Maxillo-facial Surgery, Univeristy of L’Aquila, L’Aquila.*** Dept of Surgical
Pathology, San Salvatore Hospital, L’Aquila.
INTRODUCTION
• “DENTINOMA” has been defined in 1971
by WHO as “a very rare neoplasm
composed of odontogenic epithelium,
immature
connective
tissue
and
dysplastic dentin”.
• It generally occurs in young adults,
without sex predilection.
• The mandible represents the most
common site of onset
CASE REPORT
We report on a case of a 41-year-old woman presented to
our hospital for an asymptomatic, 1,5 cm in-diameter,
radiolucent lesion of the mascellar.
The lesion was excissed and the sample was processed
routinarily in our laboratory (fixed in buffered formalyn
10%, decalcified with electrolytic decalcifyng solution,
embedded in paraffin, sectioned at thickness of 4 μm,
stained with Ematoxilin-Eosin with an automatic stainer)
Immunoistochemestry was performed with
Cytomation with antibodies provided by DAKO.
DAKO
DIAGNOSIS
• Microscopically, the lesion consisted of
dysplastic dentin without clear tubules,
scanty epithelium and rare fibrous
immature elements, stained positive for
vimentin and cytocheratine.
• The diagnosis of dentinoma was posed.
HISTOLOGY: EE
HISTOLOGY: EE
IMMUNOISTOCHEMESTRY
cytocheratine
IMMUNOISTOCHEMESTRY
vimentina
DISCUSSION
• First described by Straith in 1935, “dentinoma”
is an entity that has not been fully accepted:
some pathologists assume that this lesion must
be regarded as ameloblastic fibroma or
ameloblastic fibro-odontoma.
• In our case, the presence of dysplastic dentin
seems to preclude the diagnosis of ameloblastic
fibroma, whereas the absence of enamel
excludes the diagnosis of ameloblastic
fibroodontoma. Thus, we hypothesize the
diagnosis of dentinoma
CONCLUSIONS
• Up to now, only 20 cases diagnosed as
dentinoma have been reported in
literature.
• The rarity of this entity and the
difficulties in the differential diagnosis
lead us to report on this case.
BIBLIOGRAPHY
• 1: Anthony H. Anker et al, Dentinoma of
the mandible, Oral surg Oral med Oral
Pathol, 1989; 67:731-3
• 2: Takeda Y. et al: So called immature
dentinoma: a case presentation and
histological comparison with
ameloblastic fibrodentinoma. J Oral
Pathol Med 1994; 23:92-96