®

DERMABOND
®
Adhesive is equivalent to other commercially available skin closure devices, studied effectively from small to long incisions up to 69cm.
Closure Strength
Microbial barrier
Cosmesis
Patient Comfort showering
Ease of Care
Enduit to bacterial colonization
Removal
DERMABOND
Equivalent to 4.0
Yes
Excellent
Can Shower
Immediately
Simple
No
PLUS SUTURES
Variety
Zone of inhibition
SUTURE
Variety
No
STAPLES
Strongest
No
STRIPS
Weak
No
Excellent
Not recommended for period of time
Complicated
Excellent
Not recommended for period of time
May leave track marks
Not recommended for period of time
Complicated Complicated
Inconsistent
Not recommended
For period of time
Complicated
No Yes Yes Yes
Sloughs off naturally
May need removal May need removal Needs removal Self removal

Cyanoacrylates were developed in 1949
•
1970s - n-butyl-2-cyanoacrylate
• 1999 - 2-Octyl-Cyanoacrylate (DERMABOND)

1 st FDA approved Topical Skin Adhesive
•
Today
– over 5 million patients a year are treated with
DERMABOND Adhesive
DERMABOND Adhesive is a unique technology
• 2 Octyl cyanoacrylate has the longest carbon side chain for increased flexibility and, increased breaking strength versus butyl cyanoacrylate 1
• In vivo and In vitro studies demonstrate a proven microbial barrier against bacteria which may cause infection.
• 24 months shelf life, stores at room temperature
• a violet, non tattooing dye for easy observation
1. Quinn, JV Tissue Adhesives in Wound Care, BC Decker 1998. Attached are chapters from the book.

Mechanism of action is a combination of monomer and plasticizers, that polymerizes to form a flexible/pliable adhesive film
• Sets or cures within 45-90 seconds following final layer
• Reaches full mechanical strength in 1 min
• If needed, can be wiped from skin within
10 seconds after application or with a petroleum based product after setting
•
Adhesive film sloughs or falls off wound within 7-10 days as skin re-epithelialize
• Equivalent to 7 days wound healing strength in 3 minutes 1
OCA: 300-500 microns thick compared to other N- Butyls at : <50 microns thick
3
1. Singer and Hollander, Lacerations in Acute Wounds: An evidence-based guide , p.85 2. DERMABOND adhesive package insert

DERMBOND Adhesive has proven strength over n-butyls and n-butyl blends due to it’s unique formulation. This strength is critical for topical wound closure and microbial barrier.
Wound Bursting Strength Compliance Analysis

In vivo studies demonstrated DERMABOND Adhesive microbial barrier provides greater protection than sutures alone as well as n-butyls/ n-butyl blend adhesives.

DERMABOND
®
Adhesive has unique benefits that offer the potential to impact the cost of care.
*Health and Economic Outcomes after OB-GYN Surgery: A Comparison of Skin Closure Techniques
Susan G. Murrmann, MD 1 , Jeffrey S. Markowitz, DrPH 2 , Elane M. Gutterman, PhD 2 , Glenn Magee, MBA 3
1 University of Tennessee, Department of Obstetrics & Gynecology, Memphis, TN 2 Health Data Analytics, Princeton Junction, NJ 3 Ethicon Inc., Somerville, NJ
Sutures Staples OCA Sutures,
Staples &
OCA
N=489
Overall
P Value
Significant pairwise comparisons 1
Overall
P-Value
Significant pairwise comparisons 2
Hysterectomy Cohort
Infection as reflected by non-prophylactic antibiotic treatment
N= 21,201 N=23,441 N=880
Percent
12.93% 17.51% 11.14%
Total costs (dollars) $5862
Unadjusted Means
$6965 $5816
C-Section Cohort
Infection as reflected by non-prophylactic antibiotic treatment
N=102,797 N=50,097 N=2,391
Percent
12.83% 12.76% 9.50%
Total costs (dollars) $5572
Unadjusted Means
$5594 $5010
23.72%
$9434
N=272
13.97%
$5949
Unadjusted Analysis
<0.0001
1a,3a,4a,5a,6a <0.000
1
Adjusted Analysis 2
1a,3a,5a,6a
<0.0001
1a,3a,4a,5a,6a
Unadjusted Analysis
<0.0001
2a,4a
<0.0001
2a,4a,6a
<0.000
1
1a,3a,5a,6a
<0.000
1
Adjusted Analysis 2
2a,4a
<0.000
1
1a,2a,4a,6a
*Poster Presentation at 2008 Annual Clinical Meeting of The American College of Obstetricians and
Gynecologists, New Orleans, LA, May 3-7, 2008

•
Proven microbial barrier for lasting protection
• 7 days of wound healing strength in 1 minutes for strong closure and peace of mind
• No time spent removing staples or sutures
• Reduces needle stick exposure
• Increases patient satisfaction
• Reduced Hospitalization Costs
Nurse, Patient -centered Benefits
• Reduces number of suture set ups
• Ease of Post Op wound checks
•
Reduces number of wound dressings
• Shower immediately
• Excellent Cosmesis
Scott GR, Carson, CL, Borah, GL, DERMABOND skin closures for bilaterial reduction mammoplasties: a review of 255 consecutive cases. Plast Reconst Surg.2007;120:1460-1465.

 Remove surgical prep solution
 Ensure hemostasis
 Thin layers

Dry before bandage
 No petroleum-based products over
DERMABOND Adhesive
 Post surgical ChloraPrep wipe downs ok as long as DERMABOND Adhesive has dried and the area is not vigorously scrubbed