Sheboygan County 2013 Sandy Muesegades, RN – Public Health Nurse Completed 6 months INH - Sheboygan Immigrated to San Francisco, CA from Laos (2 children, no husband) TST 13mm March 2012 Visited family for 1 month in Thailand Again offered INH 7x. Would follow-up in Alaska Moved to Alaska 2013 2012 2011 2010 2009 2008 First sign of cough 2007 2006 2005 2004 2003 2002 2001 2000 No recall of prior TB treatment. Offered Rifampin or INH, but became pregnant 1999 1998 1997 1996 1994 Prior to 1994 Camp Ban Vinai, Thailand 1995 January – Moved to Sheboygan Took 6 weeks of INH then pregnant October 2012 Moved to Sheboygan continues with Sx January 4 October 1 Moved back to Sheboygan 2 0 1 2 October 23 Dx with Pneumonia-ED November Flight to Las Vegas December 4 Dx with Pneumonia-ED December 20 Dx bronchitis and treated for reflux-Office CXR interpreted as no active TB disease 2 0 1 3 February ED X2 February 22 Dx with asthma by a pulmonologist February 25 - March Wausau April 3 Went to clinic for depression, provider ordered CXR, cavitary lesions observed April 11 Dx with TB April 11, 2013 - The Division of Public Health was notified of a patient with suspected TB. Patient has several children. April 15, 2013- Labs confirm this patient has active tuberculosis. She was started on Rifampin, INH, Pyrazinamide, Ethambutol, and Moxifloxacin. April 16, 2013- Investigation of family: One child is coughing. Four children have abnormal chest x-rays. Suspect with TB in these 4 children. Children are excluded from 2 different schools. April 17, 2013- INH resistant detected and INH stopped April 22, 2013- One more school child living outside the home is identified and found to have an abnormal chest x-ray. April 23, 2013- Total of 6 individuals Dx with active TB. Incident Command System (ICS) activated. Contact investigation continues. May 7, 2013- MDR TB Dx in Index Case. Resistant to both INH and Rifampin. Patient hospitalized and started on Ethambutol, Pyrazinamide, Moxifloxacin, Linezolid, Amikacin, and Ethionamide. Sister’s Parents A 9 kids Patient A’s House 8 kids Adult Child Niece’s By Early May 2013- We have the MDR Index Case, 5 of her children with active TB, and 3 extended family with active TB. Total 9 cases. May 7-10, 2013- Centers for Disease Control, Mayo Clinic, State TB Program, Sheboygan Area School District Staff, Children’s Hospital and local Medical Providers conferenced with Public Health on the treatment and contact investigation recommendations. Incident Command is expanded. May 13, 2013- Local Public Health abilities have exceeded capacity. Emergency Manager brought on board. Requested IMT (Incident Management Team) assistance. Conference call for mutual aid assistance from State, Regional and Local Health Departments. May 16, 2013- Emergency Operations Center (EOC) opens. E-sponder activated. May 20, 2013- Conference call with state legislators, seeking appropriations from joint finance committee. June 3, 2013- Governor Walker and Department of Health Services issue a press release in support of funding the TB outbreak. June 4, 2013- JFC approved 4.6 million for submission in the State biennial budget. June 7, 2013- The CDC Epi-Aid team reported on the investigation, felt containment was met. June 11, 2013- Index Case transferred from hospital to Rocky Knoll Health Care Facility. June 26, 2013- Index Case returns to private single-family home in Sheboygan. August 2013- Another school age child (Index case’s son) Dx with active TB. Child had LTBI and progressed to active TB. An additional active case was detected in Marathon County, Wausau, as well as, 4 new LTBI contacts. September 2013- Another round of school testing concluded Current case count, as of October 2013 Sheboygan County Marathon County TB Disease 10 active (1 with MDR-TB) (9 INH resistant) 1 active Latent TB Infection (LTBI) 37 4 Contacts tested > 600 Directly Observed Therapy (DOT) and Case Management needs will continue into 2014-15. TX REGIMENT MDR TB Undetermined length of treatment. Ethambutol, Pyrazinamide, Moxifloxacin, Linezolid, Amikacin, and Ethionamide. Daily Directly Observed Therapy TX FOR INH RESISTANT TB Cavitary (9 months) Non-Cavitary (6 months) Ethambutol, PZA, Moxifloxacin, and Rifampin. 5-day a week Directly Observed Therapy Self-administered on weekends. Treatment is extended if self-administered on weekends. CHILDREN- Rifampin Daily X6 months. ADULTS- Rifampin Daily X4 months or Ethambutol and Moxifloxacin Daily X6 months. 5-day a week Directly Observed Therapy Self-administered on weekends. Treatment is extended if self-administered on weekends. All LTBI’s will have chest x-rays every 6 months for 2 years. Site Population Contacts Identified Contacts Tested 1st Round Positive Test for infection 2nd Round Positive Test for infection 2 Hospitals Staff 158 119 4 2 Nursing Home Staff 32 30 0 N/A 2 Clinics Staff 51 43 1 0 2 Factories Same Shift 83 72 0 0 5 Grades in 3 Schools Classmates 204 196/103 1 0 Close Friends - 10 10/9 1 1 Family and Extended family - 71 71 23 4