Lectures on respiratory physiology
Diffusion
Swim bladder of a fish
Fick’s law of diffusion through a tissue sheet
Very thin blood-gas barrier
Electron micrograph of pulmonary capillary
High power view of blood-gas barrier
Fick’s law of diffusion through a tissue sheet
Kinetic theory of gases
Fick’s law of diffusion through a tissue sheet
Diffusion and perfusion limitations
CO-Hb DISSOCIATION CURVE
110
100
CO
90
80
70
60
50
O2
40
30
20
10
0
0
10
20
30
40
50
60
70
80
90
100
PARTIAL PRESSURE, mm Hg
Diffusion and perfusion limitations
Very thin blood-gas barrier
Thickened blood-gas barrier
Time courses of Po2 in the capillary
Measurement of Diffusing Capacity
Single breath method for DCO
Electron micrograph of pulmonary capillary
Measurement of the rapid reaction of O2 with Hb
Reduced Hb
Spectro
Photometer
Mixing
Chamber
O2 solution
100
HBO2 %
t
0
0.1
time (sec)
0.2
The two components of DL
Is the transfer of CO2 ever limited by diffusion?