Crohn's disease:
‘Inflammation of the GI tract that extends through
all layers of the intestinal wall’
- Differences: can happen anywhere between
mouth - anus, healthy parts of intestine mixed
with inflamed areas, can occur in all layers of
bowel walls
-
S.S.: constant abdominal pain in right lower
quadrant, palpable abdominal mass right
lower quadrant, bloody stool, complications:
perianal fissures,fistulas, abscesses
-
Clinical manifestations: result of pathologic
changes where bowel becomes incapable of
adequately absorbing intestinal content
-
Diagnosis: made on basis of clinical history,
radiographic changes, biopsy findings of
granulomatous intestinal inflammation
-
Treatment: focused on alleviating/ reducing
inflammation & symptoms, similar
therapeutic drugs than UC: prednisone or
sulfasalazine