SKIN Bacillus subtilis . produces bacitracin on the skin, a toxin that helps it in fighting with other microbes. Staphylococcus epidermidis and other coagulase-negative Staphylococci. Corynebacterium , Propionibacterium and Brevibacterium . The most commonly isolated fungal species is Malassezia sp . which is especially prevalent in areas of the skin enriched in sebaceous glands. The Demodex mites viz. Demodex folliculorum and Demodex brevis NASAL Streptococci are sparsely present in the nasal cavity. Corynebacterium ,Aureobacterium , Rhodococcus and Staphylococcus. Staphylococcus epidermidis in 79% cases, whereas diphtheroids were in 41% cases) Staphylococcus aureus (in 34% cases). Haemophilus influenzae in 5% cases and Streptococcus pneumoniae in 0.5% case. The anaerobic bacteria found were Propionibacterium acnes in 74.5% cases and Peptococcus magnus in 3.5% cases. ORAL 600 species with distinct combination at different habitats. Most organisms that are colonizing are beneficial to human health but some microbes transit from a commensal relationship to pathogenicity oral microbiome includes the species of; Actinobacteria, Bacteroidetes, Chlamydiae, Chloroflexi, Euryarchaeota, Firmicutes, Fusobacteria, Proteobacteria, Spirochaetes, Streptococcus, Synergistetes and Tenericutes . Review Question? 1. What is the difference between the terms “normal microbiota” and “carrier state”? 2. If the normal flora of the colon is suppressed by certain antibiotics, which disease can results? 3. Explain the important anaerobes in the normal flora of the colon? 4. The vagina of some women are colonised by Escherichia coli. What is the significance of this observation? If the organisms were group B streptocooci, what would be the significance? 5. If a urine culture grew many colonies of Streptococcus epidermidis, what would be your interpretation?