Uploaded by sherida gibbs

Albumin synthesis occurs in hepatocytes which is indicated by the green border

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Albumin synthesis occurs in hepatocytes which is indicated by the green border
Well since Albumin is a protein , it is synthesized in a similar manner like the other proteins we know
Firstly, in the nucleus, Dna transcription(Transcription is the process of making an RNA copy of a
gene sequence.) and mRNA forms and leaves the nucleus via the nuclear pore into the cytoplasm
It then binds to a ribosome to form a polysome which will synthesize Preproalbumin which is
albumin with a 24 Aminoacid chain extension attached to its N terminal
This is then transported to the rough ER where 18 of those AA are cleaved by the peptidase enzyme
leaving a 6 AA chain called proalbumin. It is finally taken to the golgi apparatus where the 6AA are
removed and albumin is released
Albumin will then be secreted into blood stream immediately after its synthesis
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