Heredity and Society (Cell 1030-01) Spring, 2014 Instructor: Cherif Boudaba, Ph.D., cherif@tulane.edu; Phone: 862 8725 Office location: 4014 Percival Stern Hall, Office hours: Tuesday from 10:00 to 12:00 or by appointment. Class meets: Tuesday and Thursday, 2:00-3:15, Boggs 105 Course description: This course focuses on modern concepts related to Human genetics. Student will learn how mutated genes induce birth defects, hereditary and non-hereditary diseases. Students will be familiar with tools used to manipulate genes in order to change the genetic makeup of living plants and animals. This course will address current ethical and social issues related to gene manipulation. Course learning outcomes: After completion of this course, successful students will be able to: - Describe genes and relate them to protein synthesis leading to genetic traits - Explain the rules governing gene transmission to offspring and prediction of inherited traits - Understand gene mutation and relate it to inherited and non-inherited diseases such sickle cell anemia and cancer - Understand to which extend environment is involved in gene expression or its damage - Describe the techniques used to manipulate genes - Use scientific knowledge learned to debate current social issues related to cloning, use of embryos in research, transgenic organisms, genetic determinism, pre- and postnatal genetic testing, confidentially and discrimination… Grades: Grades are based on 2 midterms and a final exam. No makeup is given for any missed exam, except in case of sickness (must be proven by a Doctor’s note) Textbook: Yashon R. and Cummings M, Human Genetics and Society, Second Edition, Brooks/Cole, 2012. Attendance: Good attendance is important for success. Excessive absences are not tolerated and will affect student’s final grade. Honor code: All students are expected to be familiar with Tulane University Honor Code and to adhere to it. Lectures schedule Date Topic Textbook chapter January 14 Introduction and Overview 16 Cells 21 Cell division (mitosis) and Death 12 23 Meiosis, Sperm and Eggs Formation 2, 3 28 Development, Birth Defect 1 30 Sex Formation and Selection, Ethics 1 4 Reproductive Technology 2 6 Reproductive Technology and Ethics 2 11 DNA Structure and Replication 13 Exam I 18 Transcription and Translation 5 20 Mutations and Epigenetics 6 25 Changes in Chromosome Numbers 3 27 Autosomal Gene Transmission 4 Biology Basics 1 (page 2) February Biology Basics 2 (page 94) March 4 Mardi Gras No class 6 Mardi Gras No class 11 Autosomal Gene Transmission 4 13 Sex-linked Gene Transmission 4 18 Biotechnology 7 20 Genetic Testing and Prenatal Diagnosis 8 25 DNA Forensics 9 27 Exam II April 1 Genomics 10 3 Inheritance of Complex Traits 11 8 Cell Cycle and Cancer 12 10 Genetics of Behavior 13 15 Immunogenetics 14 17 Genetics and Population 15 22 Human Evolution 16 24 A Different World: Past, Present and Future Of Human Genetics 17 29 Review May 7 (WEDNESDAY) at 1:00 p.m. Final Exam