Chapter 15:Adaptive Immune Response General Characteristics • Involves specialized WBC’s known as lymphocytes • Response is highly specific, evolves throughout an organisms life-time • Response generates memory • Can discriminate between HEALTHY self and non-self OR between HEALTHY self and DAMAGED self The Adaptive Immune Response • Primary response • Secondary response • Humoral immunity: – B cells, plasma cells, antibodies: target extracellular pathogens • Cell-mediated immunity – T cells, dendritic cells – antigen is inside a cell Overview of the Adaptive Immune Response Anatomy of the Lymphoid System • Lymphatic Vessels • Secondary lymphoid Organs • Primary Lymphoid Organs Lymphocytes are responsible for the specific immune response What promotes an immune response? • Antigens – Usually proteins or polysaccharides – Foreign substance with MW of 10,000 daltons – Examples of microbial antigens: bacterial capsules, cell walls, flagella, toxins of bacteria Antibodies bind antigens Some molecules are not recognized as antigens until bound to another How are antigens recognized? • • • • Self markers also known as MHC markers MHC (major histocompatibility complex) MHC Class I-produced by all body cells MHC Class II-produced by B cells, T cells, and antigen presenting cells Structure of an antibody 5 classes of antibodies IgM Produced 1st Complement activation Primary function = neutralize pathogens in the bloodstream 10 antigen binding sites 5 classes of antibodies IgG Longest half-life Small enough to cross endothelium bbb, some types of placenta Main antibody produced in 2° immune reactions 5 classes of antibodies IgA Monomeric & dimeric Dimer = secretory IgA sIgA = most abundant Ab Secreted across mucosal surfaces in mucus & many other secretions (tears, saliva, milk) Binding → neutralize toxins, block viral and bacterial attachment 5 classes of antibodies IgE Bound to Fc region of mast cells and basophils Cross-linking of IgE by antigen → degranulation 5 classes of antibodies IgD Activation of basophils & mast cells Activation of B cells Highly conserved Functions minimally elucidated What can happen when antibody binds antigen? How are B cells activated? B cell activation by Helper T cell Primary and secondary response to antigen Memory B cells+ memory helper T cells: long lived (years) •Affinity maturation • Class switching IgM → IgG IgM → IgA Helper T cells help activate other immune cells T cells • Have own T cell receptor (TCR) • Do not make antibodies • Must recognize MHC markers which “present” antigen MHC markers Cytotoxic T cells recognize MHC Class I markers Helper T cells recognize MHC Class II Dendritic cells can activate T cells Cytotoxic T cells Cytotoxic T cells Cytotoxic T cells identify infected body cells Helper T cells activate macrophages Helper T cells activate B cells T cell-independent antigens Antibody-dependent cell-mediated cytotoxicity