AbstractID: 9696 Title: Determination of scatter loss factor for clinical high energy xray beams near tissue-air intrerface In many treatment situations like tangential breast fields, the radiation beam passes through a volume of tissue surrounded by air. The presence of air near the tissue leads to a reduction in the dose to the point of interest relative to an equivalent homogeneous volume of tissue mainly due to the loss of scatter dose. The aims of the investigation are to determine the extent of this scatter loss due to the presence of tissue – air interface and to check the accuracy of the theoretical models used by treatment planning systems (TPS) for dose calculations. The extent of scatter loss was determined experimentally by simulating the tissue – air interface by slabs of plastic water surrounded by air. The dose was measured at a fixed depth using an ionization chamber. The scatter loss factor was determined by taking the ratio of dose at the point of interest with some volume of air near it to the dose without any air, and was studied as a function of distance of the point of interest from the tissue – air interface. The preliminary results of this investigation indicate that the convolution algorithm of the CMS Focus and the pencil beam model of Varian CadPlan TPS predict the scatter loss reasonably well whereas the Clarkson algorithm of CMS Focus ignores the loss of scatter due to the presence of air. Work is under progress to study the dependence of scatter loss with depth by film dosimetry. Results of this investigation will be presented.