Ch 12 Study Guide 12.1 Know the experiments of Griffith, Avery, and Hershey and Chase What is a bacteriophage? Can you label its parts? What are the 3 functions of DNA? 12.2 Know the structure of a nucleotide What bonds join nucleotides in a chain? Are they strong or weak? What is the difference between the purines and the pyrimidines? Be able to explain the following properties of DNA’s structure: Double helix (what accounts for this shape?) Antiparallel Base pairs Rule of Base Pairing A pairs with T G with C Why does a purine pair with a pyrimidine? What kind of bonds hold the nitrogenous bases from each strand of nucleotides together? Are they strong or weak? Create a timeline with the discoveries of the following people: Chargaff, Franklin, Watson and Crick Be able to calculate the amount of each base in a DNA molecule. 12.3 What are the stages of DNA replication and the enzymes responsible for each? What is the significance of covalent bonds and hydrogen bonds in DNA replication? Compare and contrast DNA replication in prokaryotes and eukaryotes