Product datasheet
Anti-ZNF423 antibody ab87308
4 Abreviews 1 Image
Overview
Product name
Anti-ZNF423 antibody
Description
Goat polyclonal to ZNF423
This product is a fast track antibody. It has been affinity purified and shows high
titre values against the immunizing peptide by ELISA.
Read the terms of use »
Species reactivity
Predicted to work with: Mouse, Cow, Human
Immunogen
Synthetic peptide:
EPECDQKTSRALEDR
, corresponding to N terminal (near) amino acids 31-45 of Human ZNF423 (NP_055884.2).
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Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
Purity
Immunogen affinity purified
Purification notes
ab87308 was purified by ammonium sulphate precipitation followed by antigen affinity
chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Applications
Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully
characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA).
Fast track terms of use
Application
Abreviews
Notes
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Application
Abreviews
IHC-P
Notes
1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before
commencing with IHC staining protocol.
Target
Function
Transcription factor that can both act as an activator or a repressor depending on the context.
Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in
response to BMP2 leading to activate transcription of BMP target genes. Acts as a
transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal
olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and
activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a
developmental switch that regulates the transition from differentiation to maturation in olfactory
receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar
vermis formation.
Tissue specificity
Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta.
Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the
adult brain, in the substantia nigra, medulla, amygdala, thalamus and cerebellum.
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 30 C2H2-type zinc fingers.
Domain
Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and Olf
signaling pathways. C2H2-type zinc fingers 14-19 mediate the interaction with SMAD1 and
SMAD4, while zinc fingers 28-30 mediate the interaction with EBF1. zinc fingers 2-8 bind the 5'CCGCCC-3' DNA sequence in concert with EBF1, while zinc fingers 9-13 bind BMP target
gene promoters in concert with SMADs.
Cellular localization
Nucleus.
Anti-ZNF423 antibody images
This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.
IHC-P image of ZNF423 staining on mouse
lymph node section using ab87308 (dilution
1/50). The section was subjected to heat
mediated antigen retrieval using citric buffer
pH 6. The section were blocked using 10%
serum.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections) - ZNF423 antibody
(ab87308)
Image courtesy anonymus abreview
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Terms and conditions
Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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