Product datasheet
Anti-Nav1.8 antibody ab114110
Overview
Product name
Anti-Nav1.8 antibody
Description
Goat polyclonal to Nav1.8
This product is a fast track antibody. It has been affinity purified and shows high
titre values against the immunizing peptide by ELISA.
Read the terms of use »
Specificity
In preliminary western blot experiments ab114110 gave an ~150kDa band in Rat spinal cord
and Mouse NIH3T3 lysates at 1ug/ml. This band was blocked by addition of the immunizing
peptide. Please note that currently we cannot find an explanation in the literature for the band we
observe given the calculated size of 221kDa according to NP_033160.2.
Species reactivity
Reacts with: Mouse, Rat
Predicted to work with: Dog
Immunogen
Synthetic peptide:
C-DDNRSLQSDPYNQR
, corresponding to internal sequence amino acids 471-484 of Mouse Nav1.8 (NP_033160.2).
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Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 99.48% Tris buffered saline
Purity
Immunogen affinity purified
Purification notes
ab114110 was purified from goat serum by ammonium sulphate precipitation followed by
antigen affinity chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Applications
Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully
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characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA).
Fast track terms of use
Application
WB
Abreviews
Notes
Use at an assay dependent concentration. Predicted molecular weight: 1 kDa.
Target
Relevance
Nav1.8 protein mediates the voltage-dependent sodium ion permeability of excitable
membranes. Assuming opened or closed conformations in response to the voltage difference
across the membrane, Nav1.8 forms a sodium-selective channel through which sodium ions may
pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium
channel isoform. Nav1.8 plays a role in neuropathic pain mechanisms.
Cellular localization
Integral membrane protein. Nav1.8 can be translocated to the extracellular membrane through
association with S100A10.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Terms and conditions
Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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