Product datasheet
Anti-ABCC9 antibody ab133150
Overview
Product name
Anti-ABCC9 antibody
Description
Goat polyclonal to ABCC9
This product is a fast track antibody. It has been affinity purified and shows high
titre values against the immunizing peptide by ELISA.
Read the terms of use »
Specificity
ab133150 is expected to recognize isoforms NP_005682.2 and NP_064693.2.
Species reactivity
Predicted to work with: Cow, Dog, Human
Immunogen
Synthetic peptide:
C-TSEYSINNTGKAD
with a Cysteine residue linker, corresponding to internal sequence amino acids 1019-1031 of
Human ABCC9 (NP_005682.2; NP_064693.2).
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Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
pH: 7,30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Purity
Immunogen affinity purified
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity
chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Applications
Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully
characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA).
Fast track terms of use
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Application
Abreviews
WB
Notes
Use at an assay dependent concentration. Predicted molecular weight: 174 kDa.
Preliminary experiments gave an approx 90kDa band in Human Testis lysates
and 100kDa in Rat Testis lysates after 0.1µg/ml antibody staining. Please note
that currently we cannot find an explanation in the literature for the band we
observe given the calculated size of 170kDa according to NP_005682.2. The
90kDa band was successfully blocked by incubation with the immunizing peptide.
Target
Function
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscletype KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for
activation and regulation.
Involvement in disease
Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O) [MIM:608569];
also known as dilated cardiomyopathy with ventricular tachycardia. Dilated cardiomyopathy is a
disorder characterized by ventricular dilation and impaired systolic function, resulting in
congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in ABCC9 are the cause of familial atrial fibrillation type 12 (ATFB12) [MIM:614050].
ATFB12 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance.
Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial
contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in
palpitations, syncope, thromboembolic stroke, and congestive heart failure.
Sequence similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
Cellular localization
Membrane.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Terms and conditions
Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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