Product datasheet
Anti-ABCC9 antibody [S323A31] - C-terminal ab174631
Overview
Product name
Anti-ABCC9 antibody [S323A31] - C-terminal
Description
Mouse monoclonal [S323A31] to ABCC9 - C-terminal
Tested applications
IHC-P, IHC-Fr, WB, ICC, ICC/IF
Species reactivity
Reacts with: Mouse, Rat
Predicted to work with: Human
Immunogen
Fusion protein corresponding to Rat ABCC9 aa 1503-1545 (C terminal).
Sequence:
VHTILTADLVIVMKRGNILEYDTPESLLA
QEDGVFASFVRADM
Database link: Q63563-2
Run BLAST with
Positive control
Run BLAST with
Mouse brain membrane lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long
term. Avoid freeze / thaw cycle.
Purity
Protein G purified
Clonality
Monoclonal
Clone number
S323A31
Isotype
IgG1
Applications
Our Abpromise guarantee covers the use of ab174631 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
Notes
IHC-P
Use a concentration of 0.1 - 1 µg/ml.
IHC-Fr
Use a concentration of 0.1 - 1 µg/ml.
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Application
Abreviews
Notes
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 174 kDa.
ICC
Use a concentration of 0.1 - 1 µg/ml.
ICC/IF
Use a concentration of 1 - 10 µg/ml.
Target
Function
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscletype KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for
activation and regulation.
Involvement in disease
Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O) [MIM:608569];
also known as dilated cardiomyopathy with ventricular tachycardia. Dilated cardiomyopathy is a
disorder characterized by ventricular dilation and impaired systolic function, resulting in
congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in ABCC9 are the cause of familial atrial fibrillation type 12 (ATFB12) [MIM:614050].
ATFB12 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance.
Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial
contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in
palpitations, syncope, thromboembolic stroke, and congestive heart failure.
Sequence similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208)
subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
Cellular localization
Membrane.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Replacement or refund for products not performing as stated on the datasheet
Valid for 12 months from date of delivery
Response to your inquiry within 24 hours
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If the product does not perform as described on this datasheet, we will offer a refund or replacement. For full details of the Abpromise,
please visit http://www.abcam.com/abpromise or contact our technical team.
Terms and conditions
Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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