Dr. Ikhlas Said Ali Ahmed
Researcher
Education:
PhD (Molecular and Biomedical Pharmacology), University of Kentucky, USA
(2010)
MSc (Pharmacology), University of Strathclyde, Scotland, UK (2000)
BSc (Chemistry), Sultan Qaboos University, Oman (1992)
Contact details:
Room number: 2136
Office Tel.: 00968 24143432
Fax: 00968 24141107
E-mail: ikhlas@squ.edu.om
Research interest:

My research interest is to find a new biomarkers and therapeutic target for cancer
through understanding signal transduction pathway that have important role in
progression of cancer.
Publications:
1. Ahmed IS, Chamberlain C, Craven RJ. S2R(Pgrmc1): the cytochrome-related
sigma-2 receptor that regulates lipid and drug metabolism and hormone
signaling. Expert Opin Drug Metab Toxicol. 2012;8(3):361-70
2. Mir SU, Ahmed IS, Arnold S, Craven RJ.Elevated progesterone receptor
membrane component 1/sigma-2 receptor levels in lung tumors and plasma
from lung cancer patients. Int J Cancer. 2012 Jul 15;131(2):E1-9.
3. Ahmed IS, Rohe HJ, Twist KE, Craven RJ. Pgrmc1 (progesterone receptor
membrane component 1) associates with epidermal growth factor receptor and
regulates erlotinib sensitivity. J Biol Chem. 2010 Aug 6;285(32):24775-82.
4. Ahmed IS, Rohe HJ, Twist KE, Mattingly MN, Craven RJ. Progesterone
receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that
promotes tumorigenesis and is inhibited by a small molecule. J Pharmacol Exp
Ther. 2010;333(2):564-73.
5. Rohe HJ, Ahmed IS, Twist KE, Craven RJ. PGRMC1 (progesterone receptor
membrane component 1): a targetable protein with multiple functions in steroid
signaling, P450 activation and drug binding. Pharmacol Ther. 2009;121(1):149.
6. Ranney MK, Ahmed IS, Potts KR, Craven RJ. Multiple pathways regulating
the anti-apoptotic protein clusterin in breast cancer. Biochem Biophys Acta.
2007; 1772(9) :1103-11.
7. Tanira MO, Al-Mukhaini MK, Al-Hinai AT, Al Balushi KA, Ahmed IS.
Frequency of CYP2C9 genotypes among Omani patients receiving warfarin
and its correlation with warfarin dose. Community Genet. 2007; 10(1):32-7.
8. Deleu D, Aarons L, Ahmed IA. Estimation of population pharmacokinetic
parameters of free-phenytoin in adult epileptic patients. Arch Med Res.
2005;36(1):49-53.
9. Alderton F, Darroch P, Sambi B, McKie A, Ahmed IS, Pyne N, Pyne S. G-proteincoupled receptor stimulation of the p42/p44 mitogen-activated protein kinase
pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human
embryonic kidney 293 cells. J Biol chem 2001; 276 (16):13452-60.
10. Kabir S, Ahmed ISA, and Daar AS. The binding of jacalin with rabbit
immunoglobulin G. Immunological investigations, 1995; 24: 725-736.
11. Ahmed ISA, Al-Gharibi K N, Daar A S, and Kabir S. The composition and
properties of dates proteins. Food chemistry, 1994; 53: 441-446.
Link:
Research Gate