Centennial Honors College Western Illinois University Undergraduate Research Day 2012 Poster Presentation Determination of Pharmaceuticals in Water Lisa Munster Faculty Mentor: Hongxia Guan Chemistry The presence of pharmaceuticals in water is growing to become a problem for the environment. Whether they are from water treatment plants or from residential areas, they pollute the environment. Some pharmaceutically active compounds are designed to show effects at low doses. In the past, different solid phase extractions were used for cleanup and pre-concentration of trace analytes from environmental samples. These processes usually took a considerable amount of time. Development of simple and reliable methods for analysis of trace pharmaceuticals in water is a challenging task. Sample preparation must be performed to avoid false positive results due to matrix effects. Solid-phase extraction (SPE) techniques have gained increasing interest because of their selectivity and because large volume of organic solvents are not necessary. The SPE methods involved in this study was disposable pipette extraction (DPX). DPX’s rapid intrinsic mixing capability results in fast extractions with analytes being concentrated, and solvent evaporation is not necessary. Extraction of pharmaceuticals from water using this technique achieved a sample preparation throughput on the order of a few minutes per sample. Poly styrenedivinylbenzene (SDVB) was studied to achieve selective extraction of pharmaceuticals in water. It was found that SDVB provided good accuracy for the targeted pharmaceutical compounds with recoveries above 90% for most compounds.