Centennial Honors College Western Illinois University Undergraduate Research Day 2012 Poster Presentation Determination of Drugs of Abuse in Water Samantha Fitzgerald Faculty Mentor: Hongxia Guan Chemistry Drug residues can be released to surface water and drinking water, and the concentration of drug residue in water can be used to back track drug use in communities. Benzodiazepines are prescribed in large quantities for a variety of conditions, such as anxiety and insomnia, in the United States today. However, there is insufficient removal at drinking water treatment plants due to high costs. As a result, benzodiazepine drugs are the latest group emerging that is receiving a considerable amount of attention. Since most drugs of abuse are present in wastewater influent at part per billion (ppb) levels, it is necessary to develop and validate a selective and robust solid phase extraction (SPE) method for determination of benzodiazepines in water. The focus of the current project is to investigate a novel SPE method using disposable pipette extraction (DPX) for sample preparation. To achieve selective extraction of benzodiazepines in water, octadecylsilane, styrenedivinylbenzene, and weak anion exchange sorbents were studied. It was found that styrenedivinylbenzene and weak anion exchange sorbents provided good accuracy for the targeted benzodiazepine compounds with recoveries above 90%, with relative standard deviations of the recoveries below 10%, which indicates good accuracy and precision of the proposed method. One the other hand, the recoveries were below 70% for most target drugs when octadecylsilane was employed.