Fall 2015 USC-­‐Aiken BIOLA598 BIOLA598 Syllabus – Developmental Biology PROFESSOR: Dr. April DeLaurier OFFICE: Room 106, Science Building OFFICE HOURS: Monday 1:00-­‐3:00pm COURSE CREDIT: 4 Credit Hours LECTURE: (200 SCI BLDG) M/W/F 11:00 –11:50 am LABS: (104 SCI BLDG) Wednesday 1:00-­‐3:40pm CONTACT: 803-­‐641-­‐3503 E-­‐MAIL: aprild@usca.edu th
TEXT: Developmental Biology 10 edition, Scott Gilbert, ISBN 978-­‐0-­‐87893-­‐978-­‐7 LAB MANUAL: Notes to be provided. Please read this syllabus carefully and refer to it when you have questions about the course. COURSE DESCRIPTION AND OBJECTIVES: -­‐
Understand the difference between developmental biology and embryology -­‐
Learn how developmental biology can be used to complement the fields of comparative anatomy and evolution (evodevo) -­‐
Understand the history of research in the field, and key contributions of researchers -­‐
Learn anatomical, experimental, and genetic approaches to explain developmental processes -­‐
Explain key steps involved in fertilization, gastrulation, organogenesis, metamorphosis, and regeneration in a range of invertebrate and vertebrate taxa -­‐
Participate in hands-­‐on laboratory experiments to explore and manipulate developmental processes to learn their function -­‐
Develop critical thinking skills, including posing questions, hypotheses, and predictions. -­‐
Generate original experimental findings and critically evaluate how they contribute to our understanding of development. GRADE COMPONENTS: Three midterm exams 100 pts each (x3 = 300) (30%) Prelab assignments 10 pts each (x 6 = 60) (6%) Lab reports 40 pts each (x 6 =240) (24%) Final research project -­‐ Proposal 10 pts (1%) -­‐ Lab report 100 pts (10%) -­‐ Oral presentation 40 pts (4%) -­‐ Research report 100 pts (10%) Final exam 150 pts (15%) TOTAL 1000pts (100%) GRADING SCALE: 100-­‐90% = A; 89-­‐85% = B+; 84-­‐80% = B; 79-­‐75% = C+; 74-­‐70% = C; 69-­‐65% = D+; 64-­‐60% = D; 59-­‐0% = F. ATTENDANCE POLICY: “When students enroll in a particular course, they obligate themselves for all the work which may be assigned. Punctual and regular attendance is vital to the discharge of this obligation.” There are no make-­‐up exams. Should you miss an exam for a documented excusable reason (i.e. sickness or legitimate sports event participation); an alternate exam may be arranged. Fall 2015 USC-­‐Aiken BIOLA598 GRADING: Late assignments will receive an automatic reduction in score (10% per day). Assignments can be turned in early if needed. Graded materials will be returned in a reasonable time period. CLASSROOM BEHAVIOR AND PORTABLE ELECTRONIC DEVICES: It is the instructor’s right to remove any student who disrupts or disturbs the proceedings of the class. In extreme cases the professor can request assistance from the University police. If the student who has been ejected causes similar disturbances in subsequent meetings of the class, he/she may be denied admittance to the class for the remainder of the semester and assigned a grade of “F”. The use of any portable electronic devices, including cell phones, pagers, MP3 players, iPods, etc., during class is not allowed for any reason unless prior approval has been given to a student from the instructor or unless required for the course. If you are planning to have any of these devices in class, they must be turned off and stowed away for the duration of the class period. If you use a portable electronic device during a test, quiz, or other assessment, you are eligible to receive a failing grade on that assignment. DISABILITY STATEMENT: If you have a physical, psychological, and/or learning disability that might affect your performance in this class, please contact the Office of Disability Services, B&E 134, (803) 643-­‐6816, as soon as possible. The Office of Disability Services will determine appropriate accommodations based on medical documentation. WRITING CENTER: USCA provides a writing center located on room 201 of the H&SS building. If you need extra assistance on any writing assignment for this or any other class that you are taking, please try the writing center. TUTORING: Academic Success Center, Penland 108. Free one-­‐on-­‐one or group peer-­‐tutoring services. HONOR CODE: Students are expected to abide by the Academic Code of Conduct as described in the Student Handbook. Appropriate disciplinary action will be taken if academic integrity is violated. The following honor pledge is to be written, signed, and dated by the student on all exams and assignments turned into the instructor. “On my honor as a University of South Carolina at Aiken student, I have neither given nor received any unauthorized aid on this assignment/ examination. To the best of my knowledge, I am not in violation of academic honesty.” Fall 2015 LECTURE SCHEDULE FALL 2015 Date Topic Aug 21 Introduction, Comprehending development Aug 24 Comprehending development Aug 26 Fertilization: Introduction Aug 28 Fertilization: Sea urchins Aug 31 Early Development: Introduction Sept 2 Early Development: Sea urchins and tunicates Sept 4 Early Development: Sea urchins and tunicates Sept 7 Labor Day, no class Sept 9 Early Development: Amphibians Sept 11 Early Development: Amphibians Sept 14 Midterm Exam 1 Sept 16 Early Development: Fish Sept 18 Early Development: Birds Sept 21 Early Development: Mammals Sept 23 Axis specification in Drosophila Sept 25 Axis specification in Drosophila Sept 28 The stem cell concept Sept 30 Ectoderm: CNS and epidermis Oct 2 Ectoderm: CNS and epidermis Oct 5 Ectoderm: CNS and epidermis Oct 7 Dr. D at conference, no class Oct 9 Dr. D at conference, no class Oct 12 Neural Crest Oct 14 Neural Crest Oct 16 Fall Break, no class Oct 19 Midterm Exam 2 Oct 21 Mesoderm: Paraxial Oct 23 Mesoderm: Paraxial Oct 26 Mesoderm: Intermediate Oct 28 Mesoderm: Lateral Plate Oct 30 Mesoderm: Lateral Plate Nov 2 Endoderm Nov 4 Development of the Tetrapod Limb Nov 6 Development of the Tetrapod Limb Nov 9 Sex Determination Nov 11 Midterm Exam 3 Nov 13 Sex Determination Nov 16 Post embryonic development Nov 18 Post embryonic development Nov 20 Post embryonic development Nov 23 Review Session Nov 25 Thanksgiving, no class Nov 27 Thanksgiving, no class Nov 30 Oral Presentations Dec 2 Oral Presentations Dec 4 Oral Presentations Dec 7, noon Cumulative Final Exam USC-­‐Aiken BIOLA598 Chapter 1 1 4 4 5 7 7 8 8 1, 4, 5, 7, 8 8 9 9 6 6 10 10 10 11 11 8, 9, 6, 10, 11 12 12 12 13 13 13 14 14 15 12, 13, 14 15 16 16 16 Reading pp. 5-­‐14 pp. 14-­‐ 29 pp. 117-­‐134 pp. 134-­‐149 pp. 153-­‐161 pp. 217-­‐225 pp. 225-­‐238 pp. 241-­‐255 pp. 256-­‐271 pp. 271-­‐282 pp. 285-­‐298 pp. 298-­‐317 pp. 179-­‐194 pp. 194-­‐213 pp. 319-­‐331 pp. 333-­‐345 pp. 345-­‐360 pp. 360-­‐371 pp. 375-­‐393 pp. 394-­‐412 pp. 415-­‐426 pp. 426-­‐436 pp. 436-­‐447 pp. 449-­‐460 pp. 460-­‐476 pp. 476-­‐486 pp. 489-­‐502 pp. 502-­‐516 pp. 519-­‐530 pp. 530-­‐545 pp. 549-­‐558 pp. 558-­‐567 pp. 568-­‐587 Fall 2015 USC-­‐Aiken BIOLA598 Laboratory Schedule Fall 2015 Date Week Topic Prelab due Lab report due Aug. 26 1 Introduction, Lab 1: Sea Urchin Fertilization, part 1 1 Sept. 2 2 Lab 1: Sea Urchin Fertilization, part 2 Lab 1 Sept. 9 3 Lab 2: Sea Urchin Early Development, part 1 2 Sept. 16 4 Lab 2: Sea Urchin Early Development, part 2 Lab 2 Sept. 23 5 Lab 3: Xenopus Early Development, part 1 3 Sept. 30 6 Lab 3: Xenopus Early Development, part 2 Lab 3 Oct. 7 7 Dr. D at conference, no lab, take-­‐home assignment Oct. 14 8 Lab 4: Somitogenesis in chick, part 1 4 Oct. 21 9 Lab 4: Somitogenesis in chick, part 2 Lab 4 Oct. 28 10 Lab 5: Limb development in chick, part 1 5 Nov. 4 11 Lab 5: Limb development in chick, part 2 Lab 5 Nov. 11 12 Lab 6: Planarian regeneration, part 1 6 Nov. 18 13 Lab 6: Planarian regeneration, part 2 Lab 6 Nov. 25 14 Thanksgiving, no class Dec. 2 15 Oral presentations LABORATORY DETAILS: In general, labs will be “wet” and will involve working with living adult and embryonic animals. Potentially hazardous materials are used in this course. For this reason, students who do not follow instructions, use safety equipment, or conduct themselves in a professional manner will be removed from the lab. The general procedure for each exercise will be obtained from the laboratory manual and your instructor. During these labs, the student will complete experiments that require development of a hypothesis, experimental design, hypothesis testing, and drawing conclusions. The notes and results of these exercises must be maintained and turned in with the laboratory report. Lab reports will be written in part 2 of the lab exercise and will be due on Blackboard by 11:59pm on the due date. You can discuss your lab report with your lab partner and share images, but your writing must be your own.