specific functions on specific to one side of the cortex rather than bilateral brain injuries “split brain” patients imaging studies left hemisphere ◦ analytical abilities ◦ quantitative skills ◦ language right hemisphere ◦ ◦ ◦ ◦ ◦ music spatial abilities artistic abilities emotions facial recognition most well studied lateralized behavior ◦ 95% of right handed have speech on left ◦ 70% of left handed have speech on left aphasia – language deficit that cannot be attributed to motor, motivational, sensory or other explanations characterized by broken halted speech, absence of prosody non-fluent aphasia Frontal lobe agrammatism ◦ difficulty in comprehending or properly employing grammatical devices, such as verb endings and word order. anomia ◦ Difficulty in finding (remembering) appropriate word articulation ◦ difficulty mispronouncing words Copyright © Allyn & Bacon 2007 9 Can’t just be motor or it wouldn’t be an aphasia Grammatical issues with connecting words The lion was killed by the leopard. lion killed leopard. Can’t just be motor or it wouldn’t be an aphasia Grammatical issues with connecting words Non-fluent aphasia Comprehension – fairly good; ability to read – fairly good Part of the Boston Diagnostic Aphasia Test Copyright © Allyn & Bacon 2007 Copyright © Allyn & Bacon 2007 deficits observed depend on individual as well as where in this region damage occurs… ◦ fmri studies….. ◦ INSULAR CORTEX – speech articulation? ◦ apraxia? Copyright © Allyn & Bacon 2007 fluid aphasia, deficits appear to be in comprehension; words are nonsensical comprehension – poor reading ability - poor recognition of spoken words comprehension of meaning of words ability to convert thoughts into words How do we test comprehension in someone that may have Wernicke’s Aphasia? surgical requirements injection of sodium amytal or sodium amobarbital – anesthetic used to determine hemisphere important for speech split brain surgery initially – ◦ odd behaviors ◦ subsequently – only can really tell by experimental manipulations in the lab ◦ Julian Jaynes – “Breakdown of the Bicameral Mind” Functional brain imaging ◦ fMRI or PET used to see which half is active when doing a language test Copyright © 2006 by Allyn and Bacon Copyright © 2006 by Allyn and Bacon apraxia (of speech)- speech disorder with difficulty speaking correctly; not due to weakness or paralysis of speech muscles (NIDCD); complex motor commands acquired ◦ most typically in adults after brain damage developmental ◦ appears present from birth ◦ affects boys more than girls ◦ other names – verbal dyspraxia, articulatory apraxia, childood speech apraxia ◦ different than developmental delay of speech cause or causes unknown may be related to language development may be neurological disorder no specific lesions or imaging studies helpful family history of communication disorders or learning disabilities difficulty putting sounds and syllables together in correct order longer words more difficult than short inconsistent speech (say word and then unable) children – comprehension much better than expression severity can vary widely http://www.youtube.com/watch?v=szjfC9K19 0U&feature=fvsr http://www.youtube.com/watch?v=XNB0ihI2s rQ&feature=related genetic component family studies twin studies complex in terms of genes complex in terms of etiology complex in terms of traits ◦ can include phonological, auditory, motor, visual deficits which make reading even more difficult