Filling a Prescription Scenario 1 • Charlie, a 3 year-old, neutered male, Corgi mix is seen by Dr. Brown for vomiting and diarrhea • Dr. Brown diagnoses Charlie with a gastrointestinal tract infection and prescribes 2 mL Amoxi-Drop 50 mg/mL to be given BID for 7 days • Amoxi-Drop is an oral suspension: – Add required amount of water to the bottle and shake vigorously – #1 bottle 15 mL reconstituted with 12 mL water, #2 bottle 30 mL reconstituted with 23 mL water – Discard unused portion after 14 days; refrigerate after mixing – Expires 6 months after prescription date Texas A&M Veterinary Hospital College Station, TX Name: Charlie Species: Canine Date: 03/28/2015 Dr. Brown Directions: Give 2 mL by mouth every 12 hours for 7 days Mix with 23 mL of water and shake vigorously before use Refrigerate after mixing and discard after 14 days Drug: Amoxi-Drop 50 mg/mL #2, No refills Expiration: 9/28/2015 Keep out of reach of Children – For Veterinary use only Scenario 2 • “Toothless” a 12 year-old, spayed female, Maine Coon has been diagnosed with arthritis by Dr. Ag and has a standing prescription for .25 mg Triam Tabs to be taken once daily – This is a monthly prescription and can be refilled between visits • Toothless will be seen in 2 months to re-evaluate • Triam Tabs: – Available in 2 strengths: 1.5 mg and .5 mg – Store at room temperature – Expire 1 year after prescription date Texas A&M Veterinary Hospital College Station, TX Name: Toothless Species: Feline Date: 03/28/2015 Dr. Ag Directions: Give ½ tablet by mouth once daily Store at room temperature Drug: Triam Tabs .5 mg (15), 2 refills Expiration: 3/28/2016 Keep out of reach of Children – For Veterinary use only Calculating Percent Solutions Terminology •Solution- a mixture of two or more substances •Solute - the substance dissolved in the liquid solvent in a solution •Solvent - the liquid that dissolves the solute in a solution Solution Ratios • Weight in weight (W/W) – number of grams of the drug = ___Xg drug__ g of the final product 100g product • Weight in volume (W/V) – number of grams of the drug = ___Xg drug__ mL of the final product 100mL product • Volume in Volume (V/V) – number of milliliters of the drug = ___XmL drug__ milliliters of the final product 100mL product Solution Formulas • Weight in weight (W/W) – grams of active ingredient x 100 g of the final product • Weight in volume (W/V) – grams of active ingredient x 100 mL of the final product • Volume in Volume (V/V) – milliliters of active ingredient x 100 milliliters of the final product Problem 1 • If there are 30g of dextrose in 500mL of the solution, what is the percentage of solution? • W/V ratio – Grams of drug x 100 mL of final product – 30g x_100 500mL –6% Problem 2 • Determine the percent solution of a 20mL vial of 800mg Gentamicin. • W/V ratio – Grams of drug x 100 mL of final product – Strength of drug is given in mg, must convert to g – 1000mg in 1 g, 800mg x 1g_____ = .8g 1000mg – .8g x_100 20mL – 4%