October 5, 2015: Morning Session Obesity, Metabolism, and the Lung 8:00 – 9:00 Evangelos Michelakis, MD Metabolic Theory of Pulmonary Hypertension University of Alberta 9:00 – 9:45 Janice B. Allen, Ph.D. The Emerging Role of Environmental Exposures in the Obesity/Asthma Axis National Institute of Environmental Health Sciences Break 10:15 – 11:00 Kelan Tantisira, MD Circulating miRNA in Asthma and Obesity Harvard Medical School 11:00 – 11:45 Benjamin Marsland, PhD Implication of Host-Microbe Interactions in Development of Respiratory Diseases University of Lausanne 11:45 – 12:30 Stephanie Shore, PhD Obesity and Asthma: Microbiome-Metabolome Interactions Harvard School of Public Health Lunch (12:30 – 1:30) 1 October 5, 2015: Afternoon Session Obesity and Airway Disease 1:30 – 2:10 Meredith McCormack, MD Obesity, Diet and Airway Disease Johns Hopkins University 2:10 – 2:50 Deepa Rastogi, MD Metabolic Dysregulation and Pediatric Obesity-Related Asthma Albert Einstein College of Medicine 2:50 – 3:30 Fernando Holguin, MD Obesity, Metabolic Dysregulation and Airway Oxidative Stress University of Pittsburgh Break 3:50 – 4:30 Anne Dixon, MA BM BCh Phenotypes of Asthma in Obesity University of Vermont 2 October 6, 2015: Morning Session Mitochondria and Metabolism in Lung Disease I 8:15 – 9:00 Manu Jain, MD Mitochondrial Reactive Oxygen Species Regulate TGF-β Signaling Northwestern University Feinberg School of Medicine 9:00 – 9:45 Stephen Black, PhD Role of the Mitochondrion in Pulmonary Vascular Disease Georgia Regents University Break 10:15 – 11:00 Augustine Choi, MD Mitochondrial Dysfunction: Regulator of Inflammation and Cell Death in Lung Disease Weill Cornell Medical College 11:00 – 11:45 Ana Mora, MD Dysfunctional Mitochondria in Lung Fibrosis University of Pittsburgh Lunch (11:45 – 1:00) 3 October 6, 2015: Afternoon Session Mitochondria and Metabolism in Lung Disease II 1:00 – 1:45 Viswanathan Natarajan, PhD Lysocardiolipin acyltransferase, a mitochondrial cardiolipin remodeling enzyme, in the pathogenesis of pulmonary fibrosis University of Illinois at Chicago Effects of Obesity on Airway Inflammation and Asthma 2:00 – 2:20 2:25-2:45 2:50-3:10 3:15-3:35 3:40-4:30 Obesity Modulates the Alveolar Macrophage Response (NDJ Ubags, AM Wallace, S Ventrone, E Dilli, M Antkowiak, SC Frasch, DL Bratton, EFM Wouters, BT Suratt Obesity -related airway hyperresponsiveness is regulated by endothelin-1 in mice (David I. Kasahara, Norah G. Verbout, Stephanie A. Shore) The Bronchodilatory Effects of Beta-Agonist and Weight Loss are Similar in Severely Obese Patients After Bariatric Surgery (Ubong Peters, Paul Hernandez, Gail Dechman, Jim Ellsmere, Geoff Maksym) Obesity and leptin modulate airway eotaxin and MMP-9 production in allergic mice and patients with asthma (Jennifer L. Ingram, Jasmine Weiss, R. Wesley Sigmon, Akhil Hegde, Barbara Theriot, Michael Ghio, Jordan Wong, Njira Lugogo, Loretta Que, Julia Walker, Monica Kraft) Jason Bates, PhD The Mechanical Consequences of Obesity on Airways Responsiveness University of Vermont Poster Discussion and Reception (5:00 – 6:00) 4 October 7, 2015: Morning Session Lipid Handling and Mishandling: Effects on Lung Inflammation and Remodeling 8:00 - 8:40 Benjamin Suratt, MD Hypercholesterolemia and the ‘Priming’ of the Lung for Disease University of Vermont College of Medicine 8:40 - 9:20 Ross Summer, MD Dysregulated Lipid Synthesis Promotes Fibrotic Responses in the Lung Thomas Jefferson University 9:20 - 10:00 Michael Fessler, MD A Novel Role for Oxysterols in Resolution of Lung Inflammation and Critical Illness National Institute of Environmental Health Sciences Break 10:20 - 11:00 Yury Miller, MD, PhD Targeted Cholesterol Efflux and Inflammation University of California, San Diego 11:00 – 11:40 Konstantin Birukov, MD, PhD Oxidized Phospholipids in Lung Injury and Inflammation: Friend or Foe? The University of Chicago 11:40 – 12:20 Irina Petrache, MD Metabolic Derangements in COPD National Jewish Health Lunch & Conference Summary (12:20 – 1:20) 5