Cystic Fibrosis
Ventura Simmons
1/29/2010
Period: 6/7
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Summary

Cystic Fibrosis mainly affects 2 of our many
systems: -Respiratory, and -Digestive
 In these systems our airways, lungs
(respiratory), stomach, colon, and intestines
(digestive)
 These organs are affected by this disease
because Cystic Fibrosis causes a change in
the properties of the mucus that coats the
inside of these organs, and this mucus aids
the organs in surviving without it it’d be a lot
like a teenager without electronics.
Chromosome 7
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Recessive

This Disease is Autosomal Recessive meaning
you need to get the gene from both parents to
obtain it fully just like blue eyes you need a blue
eye gene from both parents to have blue eyes so if
both parents have blue eyes you will just like if
both parents have Cystic Fibrosis their child will.
 The opposite of recessive, dominant is GOOD,but
if you have one dominant than you have 1
contaminated allele a.k.a your in trouble.
 In Autosomal Recessive the word Autosomal refers to
the gene dealing with and autosome which is a cell
that isn't a sex cell and autosome deals with sex cells
but it is a somatic cell.
Allele
Definition: An allele is an alternative form of a gene
(one member of a pair) that is located at a specific
position on a specific chromosome.
C- For my slide show this will be considered the
recessive allele which mean that if a child has this as
one of its two alleles then they will most definitely carry
the disease weather it is fully or half way.
F- I used a F for my dominant allele and if u have two
dominant that is good because then you are completely
healthy but only one wont cut it. So the more F’s the
better.
FF would be homozygous dominant meaning 2 of the same dominant
FC is heterozygous dominant meaning 1 dominant and 1 recessive
Lastly CC which is homozygous recessive meaning it has 2 of the
same recessive alleles.
Punnett Squares
C
C
F
C
F
FC
FC
F
FF
FC
C
CC
CC
C
FC
CC
•homozygous dominant
•heterozygous dominant
•homozygous recessive
C
C
F
FC
FC
F
FC
FC
Punnett Square
Ratios
homozygous dominant:heterozygous dominant:homozygous recessive
1
1FF
:
:
Percentages
2
2FC
:
:
1
1CC
F
C
F
FF
FC
C
FC
CC
homozygous dominant:heterozygous dominant:homozygous recessive
25%
25%FF
:
:
50%
50%FC
:
:
25%
25%CC
Pheno and Genotype
•The F is the dominant allele and C is the recessive
allele
•Phenotype
CC= carrier and victim
FC= just carrier
FF= completely healthy
F
C
F
FF
FC
C
FC
CC
•Genotype
FF= Homozygous dominant
FC= Heterozygous dominant
CC= homozygous recessive
Phenotype Genotype
Explain Genotype and Phenotype probability using:
•Phenotype
-Ratios- 3 : 1
- Percentages- 75% : 25%
Phenotype deals with which possibilities have the
dominant alleles against the ones that don’t have any
dominant alleles
•Genotype
- Ratios- 1FF : 2 FC : 1 CC
- Percentages- 25% FF: 50% FC : 25%CC
Genotype shows the probably for ALL the allele combo’s
so FF, FC, and CC would all be classified separately.
F
C
F
FF
FC
C
FC
CC
Student Practice
F
C
Genotype:
Ratio: 3:1
Percentage: 75% yes 25% no
F
FF
FC
Phenotype:
Ratio: 1:2:1
Percentage: 25% NO
50% carrier 25% YES
C
FC
CC
Pedigree
Square: Male
Circle: Female
Orange: Full on disease
Blue: No disease at all
Half: Only Carrier
Student
Practice
Square: Male Circle: Female
Orange: Full on disease
Half: Only Carrier
Blue: No disease at all
1. What 2 other possibilities of children
could the first couple have?
2. What kind of husband would the center
circle have to marry to have a healthy
son.
3. If the first mother had a child with her son
in law what would be her chances of
having a healthy child