OBJECTIVES 1. Demonstrate application of pharmacology, pharmacotherapeutic, assessment, and pathophysiologic principles related to glucose regulation. 2. Discuss factors that influence glucose regulation and integrate current evidence-based knowledge. 3. Apply Virginia Henderson’s Unique Functions Theory. 4. Reflect on potential teaching tools for nursing education. OVERVIEW: GLUCOSE REGULATION • Definition • Scope and Categories • Risk Factors (Giddens, 2012) PATHOPHYSIOLOGY • Endocrine system • Insulin (pancreas) • Glucagon (pancreas) • Secondary Processes • Cortisol • Epinephrine • Hyperinsulinemia (Giddens, 2012) (McCance & Huether, 2014) HYPERGLYCEMIA (McCance & Huether, 2014) HYPERGLYCEMIA: CLINICAL MANIFESTATIONS • Type 1 Diabetes (Insulin deficient) • Autoimmune deficiency • Secondary to other disease • Type 2 Diabetes (Insulin resistant) • Environmental & genetic components • Metabolic syndrome • Gestational diabetes (glucose intolerance) • Physiologic complications: • Blood vessels: vessel membrane changes, hypertension, PVD, cardiovascular disease (McCance & Huether, 2014) HYPOGLYCEMIA • Exogenous factors • Medications or exercise • Endogenous factor • Pancreatic tumor • Functional factors • Liver disease • Symptoms: • tachycardia, palpitations, diaphoresis, tremors, confusion, visual changes, and seizures. • Brittle Diabetes (Giddens, 2012) (McCance & Huether, 2014) ASSESSMENT SKILLS Symptomatic history Vision Skin: • Acanthosis nigricans • Vascular changes Central Obesity Diagnostic tools: • Fasting BG • Hemoglobin A1c • Glutamic acid decarboxylase • Associated problems (Ball, Dains, Flynn, Solomon, & Stewart, 2015) (Giddens, 2012) (McCance & Huether, 2014) RESEARCH STUDY Systematic review using a priori research protocol to review the effectiveness of lifestyle interventions on high risk individuals & individuals already dx with type 2 diabetes Lifestyle interventions effectively decrease risk for diabetes Lifestyle interventions did NOT decrease cardiovascular outcomes for those with Type 2 diabetes Schellenberg, Dryden, Vandermeer, Ha, & Korownyk, 2013 PHARMACOLOGY & PHARMOCOTHERAPEUTICS Oral antidiabetic agents Insulin •Short duration; rapid acting •Short duration; slower acting •Intermediate duration •Long duration Glucose Glucagon (Giddens, 2012) (Lehne, 2013) PHARMACOLOGY & PHARMOCOTHERAPEUTICS (Giddens, 2012) THEORY Virginia Henderson’s Unique Functions of Nurses Theory • “the unique function of the nurse is to assist the individual, sick or well, in the performance of those activities contributing to health or its recovery that the person would perform unaided given the necessary strength, will, or knowledge. And to do this in such a way as to help the individual gain independence as rapidly as possible” (Henderson, 1997, p. 22). (Henderson, 1997) CONCEPT TEACHING TOOLS • Case Studies • Develop critical thinking • Understand collaboration to meet needs • A Conversation Map • Create a group of patients who have diabetes • Stimulate discussions on self-care and interventions (Sandstrom, 2006) (Strang, Bagnardi, & Williams, 2010) CONCEPT TEACHING TOOLS • Concept Map • Understand connections & system relationships • Varied learning styles, aid the visual learners SELF REFLECTION CONCLUSION REFERENCES Ball, J., Dains, J., Flynn, J., Solomon, B., & Stewart, R. (2015). Seidel’s guide to physical examination (8th ed.). St. Louis: Elsevier. Giddens, J. (2012). Concepts for nursing practice. St. Louis: Elsevier. Henderson, V. (1997). Basic principles of nursing care (2nd ed.). Washington D.C.: International Council of Nurses. Lehne, R. (2013). Pharmacology for nursing care (8th ed.). St. Louis: Elsevier. McCance, K., & Huether, S. (2014). Pathophysiology (7th ed). St. Louis: Elsevier. Sandstrom, S. (2006). Use of case studies to teach diabetes and other chronic illnesses to nursing students. Journal of Nursing Education, 45(6), 229-232. Retrieved from http://0web.b.ebscohost.com.libcat.ferris.edu/ehost/detail?sid=83455b40-2eda-4b73-87ea39d99bca682f%40sessionmgr113&vid=4&hid=122&bdata=JnNpdGU9ZWhvc3QtbGl2Z Q%3d%3d#db=cin20&AN=2009209781 Shellenberg, E., Dryden, D., Vandermeer, B., Ha, C., & Korownyk, C. (2013). Lifestyle interventions for patients with and at risk for type 2 diabetes. Annals of Internal Medicine, 159( 8), 543-551. doi: 10.7326/0003-4819-159-8-201310150-00007 Strang, S., Bagnardi, M., & Williams, S. (2010). Tailoring a diabetes nursing elective course to millennial students. Journal of Nursing Education, 49(12), 684-686. doi: 10.3928/01484834-20100831-05