Total Quoted Words are 150 words!!! Time - 9:16/47/59 According to Francis S. Collins, Director of the National Institutes of Health found on the ProCon.org website on November 16th of 2014, “Each year, more than 100 million animals; including many house-hold pets, such as, mice, rats, dogs, cats, rabbits, hamsters, guinea pigs, and birds, are killed in U.S. laboratories for biology lessons, medical training, curiosity-driven experimentation, and cosmetics testing.” Animal testings have become the norm in many research companies and organizations, but the question stands. Are we respecting the eminent rights of animals through these tests? The answer is no. Animal testing is unacceptable, and we must take action to eliminate it. In order to persuade you that we are not respecting animals when we test them in such a manner, first we will examine the inhumane elements of animal testing. Then we will take a look at how unpredictable animal testing is. And finally, we will discover how we, as consumers, can help the cause by insisting on alternative methods to testing on animals. First, Let’s examine the inhumane elements of animal testing. As of 1966, the United States passed the Animal Welfare Act, which is a federal law that addresses the standard of care animals receive at research facilities; however, this is clearly not enough protection. The AWA excludes roughly 95% of the animals tested upon, and Labs are not required to report non-AWA protected animals. According to the Humane Society International, which is an organization working to protect animals around the world, animals used in experiments are compelled to consume products, or quite opposite, are deprived of substantial amounts of food and water. Test animals endure prolonged periods of physical restraint, and the infliction of burns or other wounds to study the healing process. An example of such cruelty is the Draize eye test, which is celebrating it’s morbid 70th anniversary and is most commonly used by cosmetics companies, such as Maybelline. According to the Physicians Committee for Responsible Medicine, a non-profit organization that promotes alternatives to animal research, during this test, rabbits are immobilized in stocks with their eyelids held open by clips to evaluate the irritation caused by shampoo and other products. The FDA's own investigators have concluded that the Draize test is "plagued" by a lack of reproducibility, and that there lacks a clear relationship between rabbit and human eye responses. In short, rabbits are not humans. On March 26th of 2014, Maybelline responded to a video bloggers’ animal testing concerns. In their response, they did not deny their participation in animal testing, but did indicate they were in the process of assessing alternatives to animal testing. What exactly is Maybelline assessing, when there are alternatives that other companies; such as, Bath & Body Works, Bare Essentials, and Este Lauder, are currently using today to make cruelty free beauty products. If the tests conducted and treatments of the animals were printed on the label of the products you use most days, would you continue to use them? Next we will take a look at how unpredictable animal testing is. The reality is that over the past decades the majority of animal experiments do not contribute to improving human health, and the value of the role that animal experimentation plays in most medical advances is questionable because animals respond differently and unpredictably. A 2013 study in Archives of Toxicology stated, Animal-based toxicity testing, which causes severe suffering, distress, and death for the animals used, is typically performed without anesthesia or analgesics and is of questionable, if any, scientific value. Also, direct comparisons of mouse versus human data puts strong doubt on the usefulness of animal data as key know-how to predict human safety and wellness. The testing of just one substance alone, be it a potential drug or toxic chemical, can involve using up to 800 animals and cost over $6 million. Embryo- toxicity involves the toxic effects of a substance on the development of an embryo. In these studies, pregnant animals are killed just prior to delivery, and the fetuses are examined for any sign of toxic effects by the test substance. A standard in vivo test, which is an experiment that is done in the body of a living organism, was once described as little more than “a ritual mass execution of animals. Furthermore, the 1950s sleeping pill, thalidomide, which was tested on animals prior to its commercial release, caused 10,000 babies to be born with severe deformities. If human trials were conducted, instead of trusting embryo-toxicity, this dilemma wouldn’t have happened, or there would have been a significantly reduced statistic. Finally we will select some alternatives to animal testing. We should be following other world leaders, like those in Europe, who not only completely banned animal testing for cosmetics, but also banned the sale of any new cosmetics tested on animals anywhere in the world from entering the country, by reexamining the experimental process of testing products. Cutting-edge non-animal research methods are available, such as: micro-dosing, which is the administering of doses too small to cause any adverse reactions, can be used in human volunteers. According to Paul Locke, of the Johns Hopkins University Center for Alternatives to Animal Testing, an establishment highly involved in the replacement of animals with in vitro methods in the medical field, “40% of drugs fail in human trials because the traditional studies conducted in animals do not accurately predict how the drug would behave in humans. In 2009, the international drug regulators endorsed the use of micro-dosing in early clinical trials to improve the speed and safety of drug development. Another method is sophisticated computer models, which can predict the toxicity of substances without experimenting on animals, and also in- vitro studies, which are based on artificially creating human cells and tissues. According to the article “Saving the Animals: New Ways to Test Products” published on The New York Times website on September 12th of 2014, “These methods have been shown time and again to be more accurate than crude animal experiments.” More importantly, you can help this cause by openly expressing your opinion on the matter with the “Be Cruelty-Free” pledge today, which says no to cosmetic animal testing in the United States and worldwide. All you have to do is put pen to paper. Another way to help is to urge more than 350 U.S. universities to prohibit severe suffering in animals at campus laboratories. Even further, you can find out where your school stands, and how to make a difference. Ultimately, demand that your tax dollars and charitable donations not be used to fund experiments on animals. Help fight for the cause by asking your Members of Congress to cosponsor the Pet Safety and Protection Act, which would put random dog and cat dealers out of business, and redirect funding into the use of clinical, in-vitro, and computermodeling studies rather than laboratory animal testing; otherwise, who are we to tell companies, such as, S.C. Johnson, Band-Aid, and Clorox, who continue with their barbarous ways and relentless testing, that their actions are out of line. The first step to any predicament is to educate people. Now that we have taken an in depth look at the quandary of animal testing, we have mastered that step. The more people are educated the sooner something can be done to save the animals. With this knowledge in hand, I’m sure you will agree that animal testing is unacceptable, and we must take action to eliminate it. In order to convince you, first we examined the inhumane elements of animal testing. Then we took a look at how unpredictable animal testing is. And finally, we selected a few, safer, alternatives to testing on animals. Keep in mind, more than 100 million animals are killed each year because of various testing, but it doesn’t always have to be that way. Remember, you are the difference in making the changes you want to see. Works Cited Animal Testing Pros and Cons. 2014 йил 29-January. 2015 йил 7-January <http://animal-testing.procon.org/#background>. Collins, Francis M.D., Ph.D., Director National Institutes of Health. Animal Experiments: Overview. 2015 йил 9-January <http://www.peta.org/issues/animals-used-for-experimentation/animals-usedexperimentation-factsheets/animal-experiments-overview/>. Jensen, Meghan. Persuasive Speech Proposal. 2012 йил 6-November. 2015 йил 15January <https://sites.google.com/site/mmjense/persuasive>. Weldon, Holly. Animal Testing Outline. 2014 йил 11-December. 2015 йил 7-January <http://www.studymode.com/essays/Animal-Testing-Outline-66065851.html>.