Orion Building well-being 1 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Your primary source for what Orion is about: Suomeksi: www.orion.fi In English: www.orion.fi/en 2 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Basics about Orion • Name: Orion Oyj / Orion Corporation • Businesses: pharmaceuticals (94%) and diagnostic tests (6%) • Deep roots in Finland: • Established in 1917 as ‘Lääketehdas Orion Oy’, in Helsinki. Re-established in 2006 after a demerger of the former Orion • Operational locations in Espoo, Turku, Kuopio, Hanko and Oulu • European-wide presence with over 20 marketing companies under names Orion Pharma and Orion Diagnostica • Products • About 300 medicines and self-care products (Orion Pharma) • Active pharmaceutical ingredients, API (Fermion) • Diagnostic tests (Orion Diagnostica) • • • • 3 Market leader in Finland with 10% market share Recognised world-wide as a specialist in Parkinson’s Disease Listed on Nasdaq OMX Helsinki President & CEO: Timo Lappalainen 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Some figures 4 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion in the light of key figures Net sales, EUR million International operations, % of net sales Operating profit (EBIT), EUR million EBIT % of net sales R&D expenses, EUR million R&D % of net sales Employees at the year-end In terms of net sales, Orion ranks nr. 78 among global pharma. The figures for 2011 will be disclosed on 7 February 2012. 5 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation 2010 2009 850 772 73% 71% 254 207 30% 27% 86 95 10% 12% 3 131 3 147 Net sales are generated mainly in Europe Breakdown of the EUR 850 million net sales for 2010 By business division 3% By market area 5% 5% 44% 8% Sales through partners 29% 12% 27% 13% 13% 35% Proprietary Products Specialty Products Animal Health Fermion Contract manufacturing and other Orion Diagnostica 6 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation 35% Finland Scandinavia Other Europe North America Other Markets Half of Orion shares are held by Finnish households By number of shares Non-profit Organisations 6% By number of votes Financial and insurance corporations 1% Non-profit Organisations 7% Public sector 4% Financial and insurance corporations 1% Public sector 7% Private corporations 8% Households 50% Foreign held and nominee registered 31% Private corporations 14% Households 65% Foreign held and nominee registered 6% Altogether 141.3 million shares and over 57 000 shareholders. Both share classes are listed on NASDAQ OMX Helsinki since 1 July 2006– Share A (ORNAV) has 20 votes/share and Share B (ORNBV) has 1 vote/share, in the AGM but they have equal rights to assets and dividends. The market value of Orion Corporation at 31 December 2011 was about 2.2 billion €. 7 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Broad product portfolio. Some might be familiar to you. 8 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Medicines ’over-the-counter’ 9 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Nutritionals 10 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Non-medicinals, for personal care and hygiene 11 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Pharmacy cosmetics 12 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation For your pet 13 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Easyhaler® for inhaled asthma medicines 14 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Some background about world pharma industry 15 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Some facts about the pharmaceutical industry 1(2) World sales 2010 IMS Health: USD 875 bn in wholesale value Big multinationals and local players 10 biggest companies make 40% of the world total. Important role in healthcare 16 (Pfizer, Sanofi, Merck (US), Novartis, GSK, Roche, AstraZeneca, J&J, Lilly, Abbott) Safe, effective and better - and affordable - medicines. Education of healthcare professionals Innovation Average R&D investment is 10-15% of net sales. High regulation High product responsibility. Compliance with Good Practices (GxP) in manufacturing, laboratory, R&D and marketing. 18.1.2012 The solutions to unmet medical needs are explored in companies, with little if any public financing. Anne Allo & Sirpa Pelttari / Orion Corporation Some facts about the pharmaceutical industry 2(2) Products registered & authorised Restrictions on communication Retail sales through pharmacies Challenge of counterfeits 17 18.1.2012 All medicines shall be officially approved for marketing and clinical use. National lists. All promotional activities of prescription medicines are addressed to healthcare professionals exclusively. No consumer advertising on prescription medicines. Sales arguments must be based on approved product characteristics (= confirmed study results). In most countries, medicines are only available via pharmacies. Counterfeit (falsified, fake) drugs are an increasing global challenge. Trade in internet is very difficult to control. Anne Allo & Sirpa Pelttari / Orion Corporation Orion’s strategy How are we planning to manage? 18 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion concentrates own operations within Europe Finland Market leadership Scandinavia Strong domestic market position Eastern Europe Presence with branded generics Western and Central Europe Strong position with proprietary products Southern Europe Progress with proprietary products in hospital markets 19 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Strategic aim: Profitable growth and increased shareholder value whilst keeping business risks under control Partners and networking Flexible and efficient operations M ANAGEMENT OF COMPLEXITY IN COST-EFFICIENT WAYS 20 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Networking and partnering throughout the value chain R&D Supply Chain • R&D partnerships and networks cover all phases from preclinical to product registration • Balances risks and enables an increasing number of new research projects 21 18.1.2012 • Supply Chain operations are global and partnerships cover the whole chain of operations • Improved efficiency by “make or buy” decisions Anne Allo & Sirpa Pelttari / Orion Corporation Sales & Marketing • Partnerships in sales and marketing ensure a broad network of distribution channels • Orion’s proprietary drugs distributed worldwide • Product portfolio expanded by selling partners’ products We invest in R&D to build our future and to fight illnesses R&D is part of our mission to build well-being 22 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Our main product looks simple, doesn’t it? … But its road to market took over 10 years. 23 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation It’s all about an ideal molecule The active substance in a medicine is like a key in a lock: it either opens or closes a pathway, activates or blocks its target, typically a receptor in a cell. Entacapone, Orion’s drug discovery, acts on COMT, a very common enzyme present in the body. 24 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation The 7-17 year-long road of a molecule candidate to a new drug ”Pipeline” Research Early development Late stage development Target identification and validation Lead Molecule identification Lead Molecule optimisation Molecule candidate selection, preclinical dev. Clinical Phase I in healthy humans Clinical Phase II in a small number of real patients Clinical Phase III in a large number of real patients 8–24 months 12–24 months 18–36 months 12–24 months 12–14 months 12–36 months 18–48 months A partner company may join the work at any stage of the project • In the R&D process, the compound’s efficacy as a treatment option for the target disease • • • • • 25 and safety for the patient are explored with a purpose to confirm the compound’s superiority to already existing medicines. Each step is subject to approval of medicinal authorities (FDA or EMA). The hundreds of parallel and sequential studies generate an enormous documentation of detailed data. If successful, the results are filed into a marketing application to EMA and/or FDA. The review of the application takes 1-2 years. If OK, a marketing authorisation is granted. The compound is patented at an early stage. The protection expires after 20 years. 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Pharmaceutical R&D takes: Patience Time Money Expertise 26 18.1.2012 One molecule in a million shows some promise. Only 20-30 completely new drugs (NCEs/NBEs) are approved/introduced annually It takes at least 10–15 years to develop a completely new drug from idea to market The average cost of developing a new drug is USD 700 million. The risk of failure is high Ca. 115 000 scientists and other industry staff members are engaged in pharma R&D in the EU alone Anne Allo & Sirpa Pelttari / Orion Corporation Pharmaceutical R&D also gives: New treatments Knowledge Money Healthcare economics Innovation 27 18.1.2012 Every new treatment gives more hope to manage with a disease. For the patients and their caregivers it also means improved quality of life. Understanding of diseases and their mechanisms accumulates with every single study. Even failed projects add our knowledge. The R&D investment generates earnings some years after the new product’s launch. Effective medicinal treatments may save expensive days at hospital, e.g. Discoveries generate more disoveries to solve unmet medical needs of challenging diseases. Anne Allo & Sirpa Pelttari / Orion Corporation Orion’s R&D activity • Orion is one of Finland’s biggest investors in R&D – R&D costs are ca. 10% of our net sales Research staff accounts for 20% of our total workforce • Our purpose is to introduce new innovative treatments to global markets • Since late 1980’s we have developed 7 molecules into commercialised medicines. They now generate 50% of our net sales • We currently explore new medicinal approaches for: – – – – 28 18.1.2012 central nervous system disorders cancer critical care respiratory diseases (inhalable drugs) Anne Allo & Sirpa Pelttari / Orion Corporation Proprietary products generated 50% of Orion’s net sales for 2010 Product Indication Stalevo®, Comtess® and Comtan® (entacapone) Parkinson’s Disease 253 Simdax® (levosimendan) Severe heart failure 40 Easyhaler® product family (beclomethasone, budesonide, formoterol) Asthma, COPD 28 Dexdor® and Precedex® (dexmedetomidine) Sedative for patients in intensive care 27 Dexdomitor®, Domitor®, Domosedan® and Antisedan® (dexmedetomidine, detomidine, atipamezole ) Animal sedatives 24 Divina® range (estrogen) Menopausal symptoms 13 Fareston® (toremifene) Breast cancer 12 Total % of pharmaceutical net sales 29 18.1.2012 EUR million 2010 Anne Allo & Sirpa Pelttari / Orion Corporation 397 49 % Some helpful terms 30 OTC product (over the counter) Can be bought without doctor’s prescription Proprietary product A medicine developed in-house all the way throughout the pipeline. The originator holds full rights for the product until patent expiry. Generic medicine Off-patent. A medicine whose patent has expired. Can be copied by anyone. NCE, NBE New Chemical (Biological) Entity. An active substance based on a completely new chemical or biological mechanism of action API Active Pharmaceutical Ingredient, the substance that induces the medicinal effect of the drug Marketing authorisation (MA) The license granted by a medicinal authority (FDA, EMA, Fimea, e.g.) to sell a drug Pipeline New drug development process all the way through preclinical and clinical phases 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion and the environment Sirpa Pelttari 16.1.2012 31 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Environmental legislation: important acts, decrees and decisions for Orion • Environmental protection act 4.2.2000/86 — Act on Changing the Environmental Protection Act 647/2011 enters into force 1.5.2012 • Environmental Protection Decree 18.2.2000/169 • Old Waste Act 1072/1993 • New Waste Act 646/2011 enters into force on 1.5.2012 • Waste Decree 1390/1993 • VOC Decree 435/2001, Government Decree on the limitation of emissions of volatile organic compounds due to the use of organic solvents in certain activities and installations • Government Decree on Substances Dangerous and Harmful to the Aquatic Environment 1022/2006 • Government decison on information to be provided on hazardous waste and the packing and labelling of hazardous waste 659/1996 • Ministry of the Environment Decree on the list of the most common wastes and of hazardous wastes 1129/2001 • Chemicals Act 744/1989 • Nature Conservation Act 1096/1996 32 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Environmental Protection Act General principles provided in Section 4 for activities that pose a risk of pollution: 1) Pollution prevention and minimizing harmful impact: harmful environmental impact shall be prevented or, when it cannot be prevented completely, reduced to a minimum 2) Caution and care: proper care and caution shall be taken to prevent pollution as entailed by the nature of the activity, and the probability of pollution, risk of accident and opportunities to prevent accidents and limit their effects shall be taken into account 3) Best available techniques, BAT: the best available technique shall be used 4) Best environmental practice: combinations of various methods, such as work methods, shall be used and such raw materials and fuels shall be selected as provide appropriate and cost-efficient means to prevent pollution • ‘Polluter pays’: It is the duty of parties engaged in activities that pose a risk of pollution to prevent impact and eliminate or minimize harmful environmental effects 33 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Environmental Protection Act • General duties provided in Section 5 1) Knowledge requirement: Operators must have sufficient knowledge of their activities' environmental impact and risks and of ways to reduce harmful effects 2) Obligation to prevent pollution: If the activities cause or may directly result in environmental pollution, the operator must take the appropriate action without delay in order to prevent pollution, or, if pollution has already resulted, to reduce it to a minimum (385/2009) 3) In addition, the general duties and principles laid down Chapter 2 of the Waste Act (646/2011) must be observed in activities posing a risk of pollution. (647/2011) 34 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Environmental Protection Act • General permit requirement provided in Section 28: 1) Environmental permit: A permit is required for activities that pose a threat of environmental pollution. Activities subject to a permit are prescribed in more detail by decree. 35 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation New Waste Act 2011 • The new Waste Act and ca. 20 other acts linked to it were confirmed on 17.6.2011. • Those acts will enter into force on 1.5.2012. • The acts have been published in Statutes of Finland (Suomen säädöskokoelma), numbers 646-666/2011. • The purpose is to harmonise the waste legislation in line with today’s waste and environmental policies and the requirements of EU legislation. 36 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Waste hierarchy A waste hierarchy which complies with the EU Waste Directive (2008/98/EC) and specifies the priority of measures concerning the amount of waste, harm mitigation, and waste management: 1. Preventing the emergence of waste 2. Re-using items as such, e.g. metal barrels 3. Recycling waste as material, e.g. polyethylene plastic 4. Utilising waste as energy; energy waste is combustible waste 5. Safe landfill disposal of waste • Waste that cannot be disposed of by other means, e.g. grease trap sludge 37 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion operates under environmental permits • Environmental permits are required for Orion’s pharmaceutical manufacturing operations, as specified in the Environmental Protection Decree of Finland. • The environmental permits are granted and supervised by regional environmental authorities. 38 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion’s main site and headquarters are in Espoo 39 Orion’s site in Espoo is located in Mankkaa, next to the Tapiola sports park. About halfAnne of Allo the& Sirpa Group’s 18.1.2012 Pelttari /employees Orion Corporationwork here. Orion’s Turku site Orion’s manufacturing operations in Turku include certain tablets, hormonal products, cancer medicines and basic ointments. A major research centre is here too. 18.1.2012 40 Anne Allo & Sirpa Pelttari / Orion Corporation Fermion’s Hanko plant Fermion is a so-called fine chemicals manufacturer. It produces active ingredients for pharmaceuticals in chemical synthesis at its plants in Hanko and Oulu. 41 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion’s environmental activities • Our environmental management focus is on the following areas: — — — — — Waste and materials management Air and soil protection Energy and water consumption Wastewater Environmental burden of our products • We monitor the environmental impacts of our operations by e.g — measuring and calculating the volumes of chemicals, solvents and other substances, consumption of packaging materials, water and energy, emissions into water and air and — keeping track of waste and recording waste statistics. 42 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation ISO 14001 based system under construction • Orion wants to overperform the minimum requirements set by laws and regulations for environmental affairs • Orion publishes GRI-compliant Sustainability Reports since 2009. The ones for 2009 and 2010 are accessible at www.orion.fi/sustainability — Our management approaches and performance indicators of environmental responsibility are presented here. • An ISO 14001 based environmental management system is currently being built for Orion, first comprising the pharmaceutical preparations business (Espoo, Turku and Kuopio plants). More systematic practices and continuous improvement in environmental affairs • An Environmental Policy will be confirmed for Orion in Q1/2012. 43 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion’s current environmental engagements • Responsible Care (RC) – Orion is a member of Responsible Care, the global voluntary initiative under which chemical industries work together to continuously improve their health, safety and environmental performance. – Environmental performance is reported annually to RC • Energy Efficiency Programme of EK – As a member in the Energy Efficiency Programme initiated and coordinated by the Confederation of Finnish Industries (EK)Orion aims to cut its proportional energy consumption by 9 per cent by 2016, compared with the 2005 level. This includes the consumption of electricity, heating energy and fuels. • Carbon Disclosure – Orion reports its CO2 emissions to the Carbon Disclosure Project, CDP 44 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion’s environmental impacts • The manufacturing processes of pharmaceutical products, active pharmaceutical ingredients (API) and diagnostics products differ very much from each other. Accordingly, they also consume materials and generate emissions and waste differently both in terms of amounts and types. Common to all is • Uncompromised cleanliness • Massive air conditioning systems 45 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Absolute cleanliness is a must 46 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Water consumption and discharges Water consumption • Orion is a heavy user of water. Most of the water goes to washing the production equipment. • The waste waters from are drained to municipal treatment plants in accordance with agreements with environmental authorities. • Fermion’s Hanko plant has its own water purification plant where waste water is pre-treated before drained to the municipal treatment system. 47 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Water discharges Solid waste • Orion monitors its waste volumes using three indicators: 1) hazardous waste to be transported for disposal 2) recovered waste to be recycled, including energy waste and 3) landfill waste • All such solid waste as contains pharmaceuticals is classified as hazardous waste and is sent to Ekokem Oy at Riihimäki — Fermion produces the relatively largest amount of Orion’s total hazardous waste • The Espoo, Turku and Kuopio operations produce mostly non-hazardous recyclable materials and landfill waste. About 20% of their total solid waste is hazardous. • Orion aims to reduce waste by all applicable means. 48 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion’s objectives in waste management • Orion's objectives to reduce the production of waste are aligned with the priority targets specified in the EU-level waste strategy (waste hierarchy of the Directive 2008/98/EC on waste, Waste Framework Directive), which are included in the New Waste Act. • Avoiding the production of waste by all possible means • Efficient sorting and recycling of the produced waste materials • Hereby we also decrease the cost of waste. • Seeking ways to re-use materials • Minimised landfill waste. 49 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Emissions into air • Since 2007, companies in Finland have had to comply with very stringent emission limits for VOC quantities and concentrations. (Government Decree on the limitation of VOC emissions due to the use of organic solvents in certain activities and installations, 435/2001 at the end of October 2007) • Orion’s VOC emissions come from several solvents used by Fermion in its chemical synthesis processes, and mainly ethanol used in tablet mass production and tablet coating in the Turku and Espoo plants ― Fermion accounts for ca. 97% of the total solvents used by Orion, and for about 75% of Orion’s total VOC emissions. ― Thanks to process investments in Hanko and Oulu, Orion’s total VOC emissions dropped dramatically from 2007 (in 2010 we experienced some technical problems at Fermion’s Oulu plant). • Very small amounts of dust. • Combustion gases from the steam boiler of Espoo and Kuopio. The sulphur content of the oil is low (less than 1%) • CO2 emissions are reported for direct and indirect energy comsumption 50 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Environmental challenges for Orion to cope with • We try to minimize the use of volatile organic solvents by changing processes. • We are studying possibilities to burn the volatile solvents that evaporate from the tablet manufacturing processes and get mixed with the outlet air. ― Today, more than 90% of the volatile solvents in the plants of Espoo and Turku pass through the gas scrubbers into waste waters. • An important goal for Orion is to continuously reduce emissions in the waste water and particularly the amount of harmful substances in them. ― The means to achieve this include more efficient pre-cleaning of the manufacturing equipment. • Even better control of energy and water consumption (heat recovery systems, e.g.). 51 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Orion building environmental well-being with HH students 52 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation The world’s top 20 pharmaceutical companies 53 1-10 http:// Pfizer www.pfizer.com Sanofi www.sanofi.com Merck & Co www.merck.com Novartis www.novartis.com GlaxoSmithKline www.gsk.com Roche www.roche.com AstraZeneca www.astrazeneca.com Johnson&Johnson www.jns.com Eli Lilly & Co www.lilly.com Abbott www.abbott.com 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation The world’s top 20 pharmaceutical companies 54 11-20 http:// Bristol-Myers Squibb www.bms.com Teva www.tevapharm.com Amgen www.amgen.com Bayer www.bayer.com Takeda www.takeda.com Boehringer Ingelheim www.boehringer-ingelheim.com Astellas www.astellas.com Novo Nordisk www.novonordisk.com Daiichi Sankyo www.daiichisankyo.com Eisai www.eisai.com 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Finland’s top 20 pharmaceutical companies 1-10 http:// Orion www.orion.fi Pfizer www.pfizer.fi (MSD) ( www.msd.fi ) fuusio US-Merckin kanssa GlaxoSmithKline www.glaxosmithkline.fi/ AstraZeneca www.astrazeneca.fi/ Sanofi www.sanofi.fi Novartis www.novartis.fi Roche www.roche.fi Leiras www.leiras.fi Abbott www.abbott.fi www.bmsfinland.fi/ 55 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Finland’s top 20 pharmaceutical companies 11-20 56 Novo Nordisk www.novonordisk.fi Ratiopharm www.ratiopharm.fi Bayer Schering www.bayer.fi Lilly www.lilly.fi Boehringer Ingelheim www.boehringer-ingelheim.fi Janssen-Cilag www.janssen.fi Amgen www.amgen.com Actavis www.actavis.fi Lundbeck www.lundbeck.fi Baxter www.baxter.fi 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation These companies are also interesting ones http:// Merck KGaA www.merckgroup.com Shire www.shire.com Leo Pharma www.leo-pharma.com Santen www.santen.com Meda www.meda.se Indian pharmaceutical companies 57 Sun www.sunpharmaceuticals.com Dr Reddy’s www.drreddys.com Wockhardt www.wockhardt.com Aurobindo www.aurobindo.com Ranbaxy www.ranbaxy.com Torrent www.torrentpharma.com 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Contact Anne & Sirpa 58 Anne Allo Corporate Responsibility Officer Sirpa Pelttari EHS Specialist Orion Oyj | Orion Corporation P.O.Box 65, 02101 Espoo Orionintie 1 A, 02200 Espoo Orion Oyj | Orion Corporation P.O.Box 65, 02101 Espoo Orionintie 1 A, 02200 Espoo +358 50 966 3735 +358 10 426 3735 +358 50 966 3118 +358 10 426 3118 anne.allo@orion.fi Sirpa.pelttari@orion.fi 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation Welcome onboard to building wellbeing with us! 59 18.1.2012 Anne Allo & Sirpa Pelttari / Orion Corporation