MINISTRY OF HEALTH REPUBLIC OF UZBEKISTAN TASHKENT MEDICAL ACADEMY "APPROVED" Vice Rector for academic affairs of TMA Prof. Teshaev O.R. ___________________________ «27» august 2015y. Department: FACULTY AND HOSPITAL SURGERY Subject: FACULTY SURGERY TOPIC: ACUTE CALCULOUS CHOLECYSTITIS AND ITS COMPLICATIONS Educational-methodical technology (for teachers and medical students) Tashkent-2015 Compiled by: Professor Khakimov M.Sh. Docent Berkinov U.B. Assistant Sattarov O.T. Technology training approved: At the faculty meeting protocol number №1 of «27» august 2015y. Subject: Acute calculous cholecystitis and its complications. 1. Model learning technology in the classroom Time – 6 h Number of students – 8-10 pers. Practical session in the clinic and workshop Form of lesson using in this lesson "BLACK-BOX", "WEB". Department of facultative and hospital surgery, Venue classes training room, dressing. 1. Introduction Structure of the training 2. The practical part sessions - Supervision of patients - Implementation of practical skills - Discussion of the practical part 3. The theoretical part - Discussion of the theoretical part 4. Assessment - Self-esteem - Evaluation of teacher 5. Conclusion teacher. Assessment of Knowledge. Providing questions relating to the next class. The purpose of the lesson: clarifying the theme by showing the importance of topics for the training of students, introducing students Acute calculous cholecystitis and its complications, the reasons for their development, clinical features, differential diagnosis, optimal methods of treatment, postoperative care, rehabilitating patients. Task of the teacher: Learning outcomes: 1. To consolidate and deepen the The student should know: students' knowledge about the - Diagnosis and differential diagnosis and features clinics and course complications; Acute calculous cholecystitis - Interpretation of the results of instrumental and its complications,. diagnostic studies to substantiate the 2. Explain the principles of the diagnosis and the choice of a rational differential diagnosis. treatment; 3. Students' skills of self- - Preoperative characteristics of this category informed decision-making in of patients; the appointment of - Determine the nature of surgery and rehabilitation for patients with conservative treatment, to know their surgical diseases of gall characteristics; bladder. - To prevent complications during and after 4. Provide students the surgery; principles of prevention - To learn a special survey methods. activities. The student should be able to: Perform practical skills to acquire some Methods and techniques of training Learning tools Forms of study Conditions of learning Monitoring and evaluation practical skills in the examination of patients with Acute calculous cholecystitis and its complications, perform special techniques, survey data of patients to determine indications and contraindications for surgical interference. Methods "BLACK-BOX" and "WEB", graphic organizer – a conceptual table. Manuals, training materials, slides, video and audio, medical history. Individual work, group work, collective. Audience chamber, training room, operating room, dressing. Interpreting control: control issues, perform educational tasks in groups. 2. Motivation Instilling students with the need for timely development of adequate operations to severe complications, and in their development, encountering with the most informative and modern methods of diagnosis, surgical treatment, meeting with potential complications of surgery and operating out during the period of prevention, development of clinical thinking of students. The development of the modern view of the problem issues from the perspective of world medicine and general practice. 3. Intro-subject and inter-subject communication Teaching this topic is based on the knowledge bases of students on anatomy, normal and pathological physiology of circulation. Knowledge acquired during the course will be used during the passage of gastroenterology, internal medicine and other clinical disciplines. 4. The content of lessons 4.1. Theoretical part Complicated calculous cholecystitis. Chronic inflammatory process in the gall bladder is often associated with the development of various complications, which can be divided into two groups (Scheme 1). Scheme 1 Complications of calculous cholecystitis peritoneal forms obstructive forms Phlegmonous cholecystitis Obstructive cholecystitis Gangrenous cholecystitis (obstruction of the cystic duct, Acute gallbladder empyema gallbladder hydrops) Perforative cholecystitis (perivesical Obstruction of the bile duct infiltrate, perivesical abscess, localized (choledocholithiasis, papillary peritonitis, diffuse peritonitis) stenosis, pancreatitis) Such a division is conditional, because in clinical practice often there are cases when we have the combined lesions of the gallbladder and bile ducts. Peritoneal forms of cholecystitis characterized by the spread of the inflammatory process over the entire thickness of the gallbladder wall and its transition beyond. Phlegmonous cholecystitis. The emergence of this form of cholecystitis promote microbial factor and violation of evacuation function of the gallbladder. Inflammatory process quickly captures the entire thickness of the gallbladder wall that leads to purulent impregnation and its output infection beyond the gallbladder. The clinical picture of phlegmonous cholecystitis characterized by acute onset of the disease. Patient after errors in diet there are strong pain in the right upper quadrant with typical irradiation along the right phrenic nerve. Accompanied by recurring pain, vomiting and increased body temperature to 38-39 ° C. Patients with phlegmonous cholecystitis behave restlessly. Language they dry, the coated. Upper abdomen behind in the act of breathing. On palpation of the abdomen marked soreness and muscle tension in the right upper quadrant. Symptom of Ortner - Grekov sharply positive. There is a positive symptom of Mussy (pain when pressing your finger over the right clavicle between ne-anterior legs sternoclavicular-nipple muscle). Despite the presence of muscular protection, many patients can palpate enlarged, hard and painful gall bladder or perivesical infiltrate. In peripheral blood detected increased (up to 15000-18000) white blood cell count with leukocyte shift to the left. The disease usually progresses with the increase of local or systemic effects of peritonitis. Gangrenous cholecystitis - the most severe form of acute cholecystitis, accompanied by the development of local or general peritonitis. This form of cholecystitis often caused by the progression of abscess inflammation in the gallbladder wall. According to some authors, necrosis of the gallbladder wall promotes thrombosis of the main trunk or branches of the individual cystic artery. Other researchers believe gangrene of the gallbladder wall consequence of a severe infection with hyperergic allergic sensitization of the patient. The clinical picture of gangrenous cholecystitis in many ways resembles the clinical picture abscess cholecystitis, but with more severe intoxication organism: pointy facial features, high body temperature, repeated vomiting, dry tongue. On examination of the abdomen revealed a right upper quadrant of peritoneal irritation symptom (symptom of Shchetkin - Blumberg). If gangrenous cholecystitis around the gallbladder has no time to form distinguishes infiltrate, symptom of Shchetkin- Blumberg determined in all parts of the abdomen. Outcomes of acute cholecystitis. When acute inflammation in the gallbladder occurs on the background of the blockade of the cystic duct, may develop acute gallbladder empyema (accumulation of pus in the lumen of the gallbladder). In patients with acute empyema of the gallbladder, despite conducted anti- inflammatory treatment, remains high body temperature, accompanied by chills and sweating. Often detected light yellow skin and sclera, continued nausea and vomiting. In the right upper quadrant defined by an enlarged, hard and painful gall bladder or inflammatory infiltrate. Symptom of Ortner – Grekov is sharply positive. The picture shows the white blood purulent inflammation (pronounced leukocytosis, increased ESR), appear in the urine protein cylinders, red blood cells - the signs of toxic nephritis. Perforative cholecystitis is a consequence of abscess or gangrenous inflammation of the gallbladder wall. As a result of necrosis of the gallbladder wall its infected contents come out. When the contents of the gallbladder may extend into the free peritoneal cavity, causing the development of peritonitis general or in a cavity bounded by an inflammatory infiltrate in the lumen or soldered to the gallbladder hollow body. The clinical picture of perforation of the gallbladder is largely dependent on the phase of development of the inflammatory process in the gall bladder, the period from the onset of the disease and the degree of formation of adhesions around the gallbladder (from forming separates infiltration). Perforation of the gallbladder wall and hit its contents into the free peritoneal cavity is manifested by a sudden intensification of pain in the upper abdomen with simultaneous deterioration of general condition of the patient. In the foreground the clinical picture of acute general peritonitis. If perforation of the gallbladder wall occurs in mature separates the abdominal cavity infiltration, the picture of the limited peritonitis, subhepatic abscess. Perforation of the hollow body (stomach, duodenum or colon) leads to the formation of internal biliary fistula. In some cases, getting calculus in the duodenum and its promotion through the intestines can cause the development of acute intestinal obstruction gallstone. Obstructive forms cholecystitis characterized by a partial or complete blockage of the main bile ducts, which can be a cause of gallstone, released in hepatic bile duct from the gallbladder (choledocholithiasis), or inflammation (scar) process, which occurs in the distal bile duct due to damage its mucous shells small stones, extending into the duodenum (stenosis of major duodenal papilla). The clinical picture of obstructive forms of cholecystitis manifests the development of jaundice and acute cholangitis. Since the blockade of the distal bile duct can cause inflammation in the pancreas, some cases of cholecystitis, accompanied by bile duct blockage, proceed as choletcystopancreatitis. The most frequent symptom in the main bile duct obstruction is jaundice (icterus) - condition of the body, accompanied by staining sclera, mucous membranes and skin yellow, resulting from increasing the amount of bilirubin in the blood of the patient. Since hyperbilirubinemia in complicated calculous cholecystitis occurs at biliary obstruction, jaundice is mechanical in nature, which is characterized by an increase in the total amount of bilirubin in the blood due to its direct fraction. Main bile duct obstruction leads to stagnation in their bile (bile hypertension) and expand their diameter (cholangioectasia). Stagnation of bile in the biliary system is accompanied by morphological changes in the liver and a violation of its functions. Liver failure is still considered the most common and serious complication of mechanical obstruction of the bile ducts and in 50% of cases the cause of death of patients in the postoperative period. Jaundice in cholelithiasis, usually appears after the onset of pain in the right upper quadrant, which are characteristic forms of cholecystitis pain. In a study of patients have found clinical picture of acute cholecystitis. Violation of the outflow of bile into the duodenum, occurs against the backdrop of an acute inflammatory process in the gall bladder, leading to the development of inflammation and in the bile ducts - acute cholangitis. Morphological changes in the wall of the bile duct with acute cholangitis may be presented by catarrhal, phlegmonous or gangrenous inflammation. Clinical picture of acute cholangitis is characterized by signs of general intoxication. The main symptom of acute cholangitis is a high temperature (up to 39-40 ° C), accompanied by chills, profuse sweating at night. Patients complain of nausea, vomiting, lack of appetite. In the peripheral blood revealed leukocytosis with a shift to the left leukocyte, erythrocyte sedimentation rate increases. The close anatomical and functional relationship of the biliary system and pancreas contributes to the fact that in acute cholecystitis in the inflammatory process involves the pancreas. There are three points of view on the mechanism of inflammatory-process in the pancreas in acute cholecystitis (cholecystitis, pancreatitis): 1) infected bile reflux into the pancreatic duct occlusion with stone major duodenal papilla, edema or stenosis of the major duodenal papilla in patients with common bile duct and ampulla for pancreatic ducts; 2) the spread of inflammation of the gallbladder with the pancreas through the blood and lymph vessels; 3) violation of the evacuation of pancreatic juice blockade major duodenal papilla. The clinical picture of acute cholecystopancreatitis presented as symptoms of gallbladder and bile ducts, and pancreas. Patients complain of pain in the right upper quadrant or epigastrium, often radiating to the back and having herpes character. Often, pain radiating to the left shoulder girdle - the left-hand-frenikus symptom. Vomiting in cholecystopancreatitis is resistant agonizing character. The body temperature of 38-39 C. Abdominal palpation patients feel pain at the point of the gallbladder and pancreas area location - above the navel. With deep palpation to the left and above the navel is often possible to detect pulsations weakening of the abdominal aorta a positive sign of the Resurrection. Involvement in the inflammatory process of the tail of the pancreas appears the onset of symptoms of Mayo-Robson (onset of pain on palpation in the left costal-vertebral angle). Already in the first hours of the disease in patients with cholecystopancreatitis determined increase in blood amylase and urine diastase. In peripheral blood leukocytosis and high aneosynophilia. Diagnostics of calculous cholecystitis and its complications is based on a comprehensive examination of the patient with the help of special methods of research used in the preoperative period and during surgery. In recent years, the main method of a special study to identify the pathological process in the gallbladder, extrahepatic bile ducts in the pancreas and is ultrasound imaging. With the help of this study can be found in the gall bladder stones and set the form of inflammation of the gallbladder (Figure 3). Fig. 3. Ultrasound tomography in acute cholecystitis: a - catarrhal form; b - form of abscess; с - gangrenous form (perforation of wall) It reveals the pathological process is localized in the hepatic bile duct, a major duodenal papilla and in the pancreas (Figure 4). Fig. 4. The ultrasonic tomogram at choledocholithiasis (A) stenosis of papilla Fateri (B), the bile duct stricture (C): a - a stone; b - the bile duct; c - zone of stenosis; d - zone of stricture Identify the pathological process in the gall bladder and bile ducts by using the X-ray examination, which is carried out through a number of methods: I. Indirect contrasting of the biliary system. 1. Simple plain radiography of the liver and extrahepatic bile ducts. 2. Excretory cholecystocholangiography: a) oral; b) intravenously. II. Direct contrasting of the biliary system. 1. Percutaneous cholecystocholangiography under laparoscopic control. 2. Percutaneous transhepatic cholangiography under fluoroscopic guidance. 3. Percutaneous transhepatic cholangiography under ultrasound guidance. 4. Endoscopic retrograde cholangiography 5. Fistulo - cholecystocholangiography. 6. Operating cholecystocholangiography. Technique of X-ray studies based on indirect (excretory) contrasting of the biliary system, now almost does not apply, since their low informative. As for the X-ray inspection techniques, which are based on direct contrasting of the biliary system, they are used in patients with mechanical obstruction of the biliary tract (with obstructive jaundice). As the contrast agents are used 25-30% solutions of water-soluble iodine preparations (cardiotrast, Diodon, biligrafine, bilignost et al.). Percutaneous puncture of the biliary system, followed by conducting them in contrast solution can be performed under laparoscopic control (percutaneous transvesical cholecystocholangiography - Figure 5); Fig. 5. Percutaneous laparoscopic cholecystocholangiography. Under X-ray or ultrasound - percutaneous transhepatic cholangiography. Direct contrasting extrahepatic bile ducts may retrograde introduction of these contrasting solution at endoscopy of the duodenum (endoscopic retrograde cholangiography). In cases where in the preoperative period can not be clearly determined the status of the extrahepatic bile ducts, to identify choledocholithiasis and papillary stenosis of extrahepatic bile ducts examined during operation is used operating cholangiography (Figure 6). Fig. 6. Roentgenograms in the direct contrasting of bile ducts: a - a stone in the bile duct b – stenosis at terminal part of the common bile duct; During surgery to examine the bile duct, you can use special fiberscope (choledochoscopy). This examination reveals inflammation in the wall of the bile duct (cholangitis), as well as to detect not removed concrements. Treatment of calculous cholecystitis and its complications. In identifying of calculous cholecystitis it’s need to raise the question about the indications for surgical treatment. Tactics to perform early surgery for calculous cholecystitis is based on the fact that even in uncomplicated forms of the disease morphological changes in the wall of the gallbladder suggest persistence of the pathological process. In addition, at 30-40% of patients with calculous cholecystitis in the pathological process there is involved the extrahepatic bile duct, duodenal papilla large and pancreas. Against the background of chronic inflammation in the gallbladder may develop a malignant tumor. Therefore, early surgery is intended to prevent the development of complications calculous cholecystitis. So far, surgeons are not formed a consensus on the timing of the operation in complicated forms of calculous cholecystitis (acute inflammation of the gallbladder). Some of them consider it necessary to perform surgery in the early hours of admission to hospital. Others recommend to handle patients after acute inflammation subsided phenomena and perform pre-operative rehabilitation of the bile ducts. This point of view in the conditions of use of ultrasound, which allows us to observe the dynamics of inflammation in the gallbladder wall under the influence of anti-inflammatory therapy should be considered more rational. Emergency surgery should be performed only in those cases when acute cholecystitis revealed a picture of diffuse peritonitis. If the timing of performing surgery surgeons argue that on the surgical approach their opinion united - in the surgical treatment of patients with calculous cholecystitis is necessary to remove the gallbladder and remove all the complications of the extrahepatic bile ducts and the major duodenal papilla. Removal of the gallbladder (cholecystectomy) is performed as a wide laparotomy access, and by means of minimally invasive interventions laparoscopic cholecystectomy or cholecystectomy from mini-access. To eliminate the pathological processes, which are in the extrahepatic bile duct, usually produce autopsy lumen of the bile duct (choledochotomy). Most often, the lumen of the bile duct is exposed longitudinal section of its wall in supraduodenal department. After opening the lumen of the bile duct stones were removed from it (choledocholithotomy) and produce the removal of papillary stenosis (transcholedocheal papillosphincterotomy). Convinced of the complete elimination of pathological processes biliary tract, bile duct wall wound sutured tightly with unresponsiveness suture using a precision technique seam (sewn fabric wall of the bile duct, located above the duct mucosa). In some cases choledochotomy can be completed or external drainage of the bile duct by a Tshaped latex drainage or formation biliodigestive anastomosis (choledochoduodeno- or choledochojejunoanastomosis). In cases where there is a papillary stenosis or stone prejudiced in his vial perform transduodenal papillosphincterotomy followed by removal of the stone. The introduction of the surgical practice of endoscopic surgery has significantly changed the surgical approach with calculous cholecystitis and its complications. Currently, the operation of choice in calculous cholecystitis is laparoscopic cholecystectomy. During laparoscopic cholecystectomy can be performed and choledocholithotomy that ends overlay blind stitch the wound channel. To eliminate choledocholithiasis or papillary stenosis preoperatively performed endoscopic transduodenal papillosphincterotomy and lithoextraction. 4.2. New teaching technologies used in this lesson "Black-box", "Web": USE OF THE “BLACK BOX”. The method provides for joint activities and active participation in the classroom each student, the teacher works with the entire group. Each student takes out a "black box" issue. (Options of questions are attached). Students are required to detail the reasons for his answer. To think about each answer the student is given 3 minutes. Then discuss the answers, given in addition etiopathogenesis, clinical course. At the end of the method of teacher comments on your answer is correct, its validity, the activity level of students. This methodology promotes student speech, forming the foundations of critical thinking as In this case, the student learns to assert his view, analyze responses band members - participants of the contest. USING "WEB". Steps: 1. Previously students are given time to prepare questions on the passed occupation. 2. Participants sit in a circle. 3. One of the participants is given skein of thread, and he sets his prepared question (for which he must know the full answer), hold the end of the filament coil and transferring to any student. 4. A student who receives skein, answers the question (in this party, who asked him, commented on a response) and passes the baton on the issue. Participants continue to ask questions and answer them until everything will be in the web. 5. Once students have completed all the questions, a student holding a roll, returning his party, from whom he received the issue, while asking his question, and so on, until the "unwinding" of the coil. Note: To prevent the students who should be attentive to each answer, because they do not know who to throw skein. 4.3. Analytical part Situational problem: Patient after a fatty meal had pain in the right upper quadrant, the yellowness of the skin. I. Your diagnosis : A. Mechanical jaundice. * B. colitis V. gastritis G. miolgiya D. arthrosis 5. Practical part Performed of mission on the practical knowledge (to shepherd of differential diagnostics and grounded conclusion diagnosis, appointed corresponding diet and planning therapy, USI). 1. HOLD DIFFERENTIAL DIAGNOSIS AND JUSTIFY THE FINAL DIAGNOSIS. Purpose: To educate and carry out a differential diagnosis to justify a definitive diagnosis. Fully Not № Activity implemented fulfilled correctly 1. List the disease, clinical symptoms, which are 0 25 similar to the disease. 2. Make a differential diagnosis of major clinical 0 35 syndromes. 3. On the basis of complaints, medical history, 0 40 objective data and results of laboratory and instrumental examinations, as well as differential diagnosis to put a definitive diagnosis. Total № 1. 2. 3. 4. 5. 6. 0 100 2. APPOINT APPROPRIATE DIET AND PLANNED TREATMENT. Purpose: The treatment of the disease and to achieve remission. Fully Not Activity implemented fulfilled correctly The study of the characteristics of medical tables on 0 10 Pevsner. The right choice of dietary table in accordance with 0 10 the diagnosis. Assessment of usefulness of the diet 0 20 In accordance with the diagnosis, disease severity 0 20 and stage of the appointment of primary therapy. In accordance with the diagnosis, disease severity 0 20 and stage of the appointment of symptomatic therapy. Prophylactic measures. 0 20 Total 0 100 3. THE TECHNIQUE TUBING OF STOMACH. Purpose: to the prophylactic of aspics by the stomach contents, to preparing of stomach to operation. Not Fully implemented № Activity fulfilled correctly 1 Calm patient, explain manipulation 0 10 2 Get on of surgical thumb . 0 10 3 Measurement distention from the 0 10 mouth until stomach. 4 Put on of the stomach tube by the 0 10 nose. 5 Suck content of stomach with 0 10 helping hypodermic Jane. 6 Fixation tube with bandage and 0 10 banding around of the face of patient. 7 Bathe tube with physiological 0 10 solution and periodic moved of tube for prophylactic adhesion to mucus of stomach. 8 Repetitively suck until full cleaning 0 10 of stomach 9 Estate of medical instruments to 0 10 dez.solution 10 Get off surgical thumb and estate of 0 10 to dez.solution . Total 0 100 6. The form control of knowledge 1. Spoken; 2. Written; 3. Answer to situation problem; 4. Demonstration of the reclaim practical knowledge. № 7. Criteria for evaluating the current control Evaluation Progress in % The level of student knowledge 1 96-100% Perfect “5” 2 91-95% Perfect “5” 3 86- 90% Perfect “5” 4 81-85% Well “4” 5 76-80% Well “4” Complete the correct answer to the questions. Summarizes and makes decisions, creative thinking, self-analyzing. Solve situational problems correctly, with a creative approach, with full justification for the answer. Actively and creatively participate in interactive games, the right to make informed decisions and summarize, analyze. Complete the correct answer to the questions. Creative thinking, self-analyzing. Solve situational problems correctly, with a creative approach, the rationale for the answer. Actively and creatively participate in interactive games, the right decision makers. The questions covered completely, but there are inaccuracies in the answer 1/2. Independently analyzed. Inaccuracies in solving situational problems, but with the right approach. Actively involved in interactive games, make the right decisions. The questions covered in full, but there is a 3/2 inaccuracies, errors. Into practice, understand the essence of the issue, says confidently, is a faithful representation. Case solved the problem correctly, but the rationale for not fully answer. Actively involved in interactive games, make decisions correctly. Correct, but incomplete coverage of the issue. Understands the issue, says confidently, is a faithful representation. 6 71-75% 7 66-70% 8 61-65% 9 55-60% 10 50-54% Actively involved in interactive games. On case studies gives a partial solution. Well Correct, but incomplete coverage of the issue. Understands the issue, says confidently, is a “4” faithful representation. On case studies gives a partial solution. Satisfact The correct answer to half the questions. ory Understands the issue, says confidently, “3” is accurate representations only on individual issues topics. Case solved the problem correctly, but there is no justification response. Satisfact The correct answer to half the questions. ory Says uncertainly is accurate “3” representations only on individual issues topics. Mistakes in solving situational problems. Satisfact Reply with errors on half of the questions. ory Says uncertainly, is partial view on the subject. “3” Case solved the problem incorrectly. Unsatisfa The correct answer to the third set of questions. ctory “2” Situational problems solved correctly if the 11 46-49% Unsatisfa ctory “2” 12 41-45% Unsatisfa ctory “2” 13 36-40% Unsatisfa ctory wrong approach. The correct answer to the fourth set of questions. Situational problems solved correctly if the wrong approach. Lighting fifth of the questions correctly. Gives incomplete and partially incorrect answers to questions. Lighting 1/10 of questions at the wrong approach. “2” 14 31-35% Unsatisfa To the questions are not answers. ctory “2” 8. Chronological map of lessons № Steps of lessons 1. Introductory word teacher (study subjects). 2. Discussion topics practical lessons, assessment of baseline knowledge of students with new educational technologies (small groups, case studies, business games, slides, videos, etc.). Forms of the lessons The survey, an explanation Duration in min. of 90 5 25 3. Summing up the discussion. 4. Providing students with visual aids and giving explanations to them. 5. Self-study students in mastering skills. 6. Clarification of the extent to which lessons objectives on the basis of developed theoretical knowledge and practical experience on the results and taking into account this evaluation activities of the group. 7. Conclusion of the teacher on this lesson. Assessment of the students on a 100 point system and its publication. Cottage set on the next class (a set of questions). 5 10 Oral interview, written survey, testing, checking the results of practical work, discussion debate. Information, questions for selfstudy. 15 25 5 9. Control questions 1. Define cholangitis 2 . The main cause of jaundice . 3 . The main diagnostic methods choledocholithiasis . 4 . Classification of AC and its complications. 5 . Indications for conservative treatment of complications AC. 6. Indications for surgical treatment of complications AC. 7. The general principle of surgical treatment for complications AC. 8. Recommending literature I. Fundamentally: 1. Surgical diseases. Sh.I. Karimov. Tashkent 2011 . 2. Surgical diseases. Sh.I. Karimov, N.Shamirzaev, Tashkent, 1995. 5. Surgical diseases. M.I.Kuzin, Moscow 2002. 6. Operation to the internal organs. Voylenko I. GEOTAR. Moscow. 2000. 7. The preparatory surgery Yu.L.Shevchenko. Sanct-Petersburg. 2000. II. Additionally: 8. J. H. Davis Clinical Surgery. St. Louis: C. V. Mosby Co., 2007. 9. Dinarello, C. A., Cannon, J. G., and Wolff, S. M. New concept on the pathogenesis of fever. USA, 2008. 10. Polk, H. C., Jr. Principles of preoperative preparation of the surgical patient. In D. C. Sabiston, Jr. (ed.), Textbook of Surgery: The Biological Basis of Modern Surgical Practice (14th ed.). Philadelphia: Saunders, 2004. 11. Wilmore, D. W., et al. (eds.). American College of Surgeons Care of the Surgical Patient. New York: Scientific American, 2005. 12. Dougherty, S. H., and Simmons, R. L. The biology and practice of surgical drains. Part I. Curr. Prob. Surg., 2006. 13. Dougherty, S. H., and Simmons, R. L. The biology and practice of surgical drains. Part II. Curr. Prob. Surg., 2006. 14. Haaga, J. R. Imaging intraabdominal abscesses and nonoperative drainage procedures, Prague 2007. 15. Robinson, O. J. Surgical drainage: A historical perspective. Handbook. New York. 2006. 16. E. Etala Atlas of abdominal surgery. Argentina. 2006. 17. Address on the internet: www.rmj.net, www.consilium-medicum.com, www.mediasphera.ru, www.laparoscopy.ru, www.ehpb.com, www. medmore.ru, www.gastroportal.ru, www.medilexicom.com, www.encicloperdia.com, www.omoc.su, www.medline.ru