Medical Imaging Resource Center (MIRC)
Research Applications
J. Jeffrey Carr, MD, MSCE, FACC
Division of Radiological Sciences, Internal Medicine - Cardiology
& Public Health Sciences
No disclosures
Support through grants from NIH/NHLBI/NIAMS/NIDDK & WFUHS
Presenter Disclosure
Information
J. Jeffrey Carr
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still investigational: None
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J. Jeffrey Carr
Imaging Research
• Established and novel phenotypes
– Clinical and subclinical disease
– Numerous modalities (DICOM format)
• Small to Large studies
– 10,000+
– Multiple exams (change over time)
• Multiple field centers across the world
• Relatively Short time periods
– Most projects < 5 years duration
How Does MIRC support
• Transfer of image and other information?
• Participant identification & confidentiality?
• Data Cleaning (i.e. fixing mistakes)?
• Quality Control / Data Tracking?
Challenges
• Large amounts of data
– CT: ~ 400 images [200 MB]
– CTA ~ 2,500 images/study [1.25 GB]
– 6,000 exams = 1.2 -7.5 TB
• Complexity of data management
• Quality Control
• Confidentiality
Imaging Research at Wake Forest
using MIRC toolkit
Women's Health Initiative
Memory Study (NIH)
Coronary Artery Risk
Development in Young Adults
(NHLBI’s CARDIA)
 Women's Health Initiative
(WHI-CACS)
Carotid Atherosclerosis
MRI Progression
 Alzheimer's Disease
Neuroimaging Initiative
 Crash Injury Research &
Engineering Network
Network Security
• Each Institution has established security
procedures and personnel
• Electronic Transfers
– Security issues at each end
• Media (CD/DVD) + Courier
– Liabilities related to physical media
Internet
DICOM
CT System
imaging analysis
workstation
Internet
Remote CT
Firewall
X
DICOM
X
imaging analysis
workstation
Firewall
DICOM import
to HTTP export
Internet
Remote MIRC
FieldCenter
DICOM
Remote CT
Firewall
imaging analysis
workstation
Firewall
DICOM import
to HTTP export
HTTP import
to DICOM export
Internet
Remote MIRC
FieldCenter
HTTP
WFUSM MIRC
DICOM
DICOM
Remote CT
Firewall
imaging analysis
workstation
Firewall
CARDIA year20 data flow
UIC/USF to DMZ WFUSM MIRC
Internet
WFUSM
firewall #1
MIRC
software
Remote
Network
UIC CT
Remote
Network
USF CT
Remote MIRC
FieldCenter
HTTP import to DICOM export (MIRC IN to Titan)
HTTP import on http://182.158.1.101:8443/CARDIA_WFU/import/doc
DICOM export from CARDIA_WFU@192.158.1.101:3333 to CARDIA_XX (Titan)
WFUSM
firewall #2
RAID storage
WFUSM MIRC in DMZ
MIRC IN: 182.158.1.101: port 8443 (ext)
192.158.1.101: port 104,3333,8443 (int)
WFUSM DICOM research server
Titan: 192.168.1.110: port 104
AE TITLE: CARDIA_XX
WHI data flow
UIC
USF UPMC
UMN
CDs sent via
from 26 Field Centers
Remote
Network
FileSender
Remote MIRC
FieldCenter
Loaded on WFUSM
MIRC receiver
Calcium scoring
workstations
Internet
WFUSM
firewall #1
WFUSM MIRC receiver
RAID storage
WFUSM MIRC in DMZ
WFUSM
firewall #2
WFUSM DICOM research server
WFUSM
Firewall
WFUSM MIRC hardware configuration
TeraRecon
imaging analysis
workstation
GE Advantage
imaging analysis
workstation
Internet
Remote
Network
Remote MIRC
FieldCenter
WFUSM MIRC
in DMZ
WFUSM
Network
Internet
External RAID
backup system
MIRC within
WFUSM firewall
Remote CT
External
Ultra SCSI3
Remote MR
WFUSM NAS
WFUSM research
DICOM server
WFUSM DICOM research images
Long term storage and archiving
Exabyte VXA-2
Autoloader (1 x 10)
External attached RAID
Ultra SCSI-3
Raid5 configuration
NAS (network attached storage)
EMC
WFUSM NAS
Fiber attached
Raid5+1 configuration
Research archiving server
VXA-2 Tape (80/160GB)
DVD-R (4.7/8.5GB)
Sony external
DL/DVD±RW drive
WFUSM research
archiving server
WFUSM MIRC
receivers
External RAID
backup system
WFUSM
Network
WFUSM research
DICOM server
Identification of Research
Participants
• Name? (HIPAA
Concerns)
• De-identification
• Study identifiers
• Clinical HIS/RIS
issues
How to fix mistakes &
Problems?
• Study identifiers
• Missing / inconsistent / problematic
DICOM fields
• Clinical HIS/RIS issues
MIRC DICOM Editor
MIRC software tools
FieldCenter
Application to receive DICOM images from an imaging modality
DICOM export images from remote sites to reading center via internet
Anonymize/de-identify/modify DICOM images
DicomEditor
Modification and correction of DICOM header
Powerful anonymization/de-identification tool
Batch modifying application
FileSender
DICOM export corrected images back to workstation/DICOM server
DICOM export images from local media and network drives
MOD
CD-rom/DVD-rom
Hard drive
Other misc media formats
Conclusions
• MIRC supports secure transfer of images
and other data
• MIRC enables central participant deidentification
• MIRC facilitates Data tracking, Cleaning &
Quality Control
• MIRC greatly simplifies research
management
Special Thanks to:
Josh Tan (Formerly WFUSM now TeraRecon)
John Perry (RSNA)
Peter Santago, Ph.D. (WFUSM)
Kerry M. Link, M.D. (WFUSM)
Bob Ellison (WFUSM)
Nick Bryan, M.D., Ph.D. (UPenn)
Lisa Desiderio (UPenn)
DengFeng Liu (UPenn)
Steve Moore (Mallinckrodt)
Acknowledgements:
Wake Forest University School of Medicine (Radiology and Biomedical Engineering)
Wake Forest University Health Sciences
University of Pennsylvania
Winston-Salem State University
Thank You!
Division of Radiologic Sciences
and Public Health Sciences
www.wfubmc.edu/imagelab