Myers’ PSYCHOLOGY (7th Ed) Chapter 2 Neuroscience, Genetics and Behavior James A. McCubbin, PhD Clemson University Worth Publishers 1 Understanding the Brain….D—Ohhhhh!!! 2 3 Neural Communication Biological Psychology branch of psych concerned w/ links between biology & behavior some biological psychologists AKA: behavioral neuroscientists neuropsychologists behavior geneticists physiological psychologists…..or biopsychologists Neuron a nerve cell It’s the basic building block of the nervous system 4 Parts of a Neuron: Dendrite: bushy, branching extensions of a neuron that receive messages & conduct impulses toward the cell body Axon: extension of a neuron, ending in branching terminal fibers, -messages are sent thru it to other neurons or to muscles or glands Myelin [MY-uh-lin] Sheath: a layer of fatty cells segmentally encasing the fibers of many neurons enables vastly greater transmission speed of neutral impulses… deterioration can = multiple sclerosis Another “demyelinating” disease: Guillain-Barre Syndrome: Action potentials in peripheral NS --faulty immune reaction attacks the myelin 5 Neural Communication 6 7 Neural Communication Synapse [SIN-aps] Where the end of 1 neuron (axon terminus) & dendrite of next neuron join up… tiny gap at this junction is called the synaptic gap or cleft EACH neuron can make up to 10,000 connections!!! Neurotransmitters chemical messengers that cross the synaptic gaps between neurons when released by the sending neuron, N-T’s travel across the synapse & bind to receptor sites on the receiving neuron, & this influences whether it will generate a neural impulse 8 Cell A: Sending neuron Cell B: Receiving neuron 9 Neural networks or connections Inset shows vesicles + receptor sites + neurotransmitters being released from axon of sending to dendrite of 10 receiving.. Neural Communication Action Potential: a neural impulse; a brief electrical charge that travels down an axon generated by the mov’t of positively charged atoms in and out of channels in the axon’s membrane Threshold the level of stimulation required to trigger a neural impulse 11 Neuron’s (elec.) impulse = action potential: [“I sing the body electric!” (WW) ] Signals from other neurons can be excitatory (accelerator) or inhibitory (brakes) “party animal vs. party pooper”: fires if animals win! Reaction = is “All-or-nothing”: Like a gun: It fires …or doesn’t Strength of stimulus does NOT = stronger a impulse It IS just more neurons firing EX: Light touch … or big hug? 12 Synapse = 1/millionth of inch wide! N-T’s jump this & carry impulse across thru chem. Process (What does “N-T” stand for???) Chemical process: is “selectively permeable” i.e., blocks out sodium ions when “resting”… When hits threshold, charge comes … GATES open & let in sodium (Na) This carries charge down to terminal buttons… Then neurotransmitters (N-T’s) take over 13 (+) & (-) ions: • Fluid inside = (-) ions • Fluid outside = (+) ions When it’s like this it is a resting potential (ain’t fired up yet!) Gates open …..(+)Na ions get in = firing as reaches threshold…when +Na inside = more than -Na inside Refractory (resting) period: As each section of axon fires & carries the impulse, it then “rests” (refractory) & it pumps the Na back out… Analogy: like a camera battery..get green light…take pic… get red light… camera has to “rest & recharge It’s then able to fire again 14 Neural Communication Cell body end of axon Direction of neural impulse: toward axon terminals 15 Neural Communication 16 Neural connections in a neural network: What they really look like… 17 Neural Pathways: • Neurotransmitters: Each N-T has specific routes thru brain… …& these = “pathways” • Functions: see table 2.1, p. 62 EX: Endorphins (“morphine w/in”): released to deal w/ pain….w/ psych. stress….& also w/ strenuous exercise (Endor. can also affect moods) 18 Pathways: Route each N-T takes… Route thru brain is different for each N-T Serotonin Pathways Dopamine Pathways19 The Dopamine Pathway hits a LOT of areas that deal with pleasure, emotion, etc. Dopamine is plays a large role in many drug addictions 20 Neural Communication…p. 62 KNOW THESE!!! 21 Some major N-T’s: Acetylcholine [ah-seat-el-KO-leen] = ACh Some of its functions: triggers muscle contractions… motor activ. muscle action + invol. mov’t (heart, etc.) joints possible memory & arousal (Alzheimer’s) NOTE: many poisons block or mimic Ach Endorphins [en-DOR-fins] “morphine within” natural, opiate-like N – T’s more linked to pain control & to pleasure Ease pain sensation, help mood: happiness, feel good (“sense of well-being”), etc… Stress…pain….strenuous exercise 22 Dopamine: involved in volun. mov’t • Also atten. & basic learning • “reward centers” (pleasure) • too little: Parkinson’s too much: Schizophrenia Serotonin: affects mood; also pain control… control of eating, sleep, & arousal May affect dreaming too much = mania too little, depress. Norepinephrine: alertness, wakefulness…& mood GABA: Sleep eating disorders Glutamate: a major excitatory N-T • Involved in memory • Too much: over-stimulates brain & = migraines (MSG in Chinese food?) 23 SSRI’s (selective serotonin reuptake inhibitors) Stops re-absorption of serotonin back into vesicles, allowing more to be processed used to fight depression 24 Agonists & Antagonists: Agonist: similar enough to mimic NT It excites & gets receptors going more than usual… EX: morphine does this to endorphin receptor sites Antagonist: it inhibits N-T’s Similar enough to take NT’s place, but not cause needed action in receptor EX: ACh & poison curare: blocks reception of NT Muscles (which?) don’t work…& we’re paralyzed …& die 2 ways: Antagonists can inhibit (hold back) NT's release OR… can be enough like the NT that it occupies the site & blocks (EX: curare) its effect, but can't mimic it, so does NOT stimulate the receptor Note: DVD: Brain, Univ. w/in: Evolution 25 N-T “Lock & key” system Neurotransmitter molecule Receptor site on receiving neuron Receiving cell membrane Agonist mimics neurotransmitter Antagonist blocks neurotransmitter 26 27 Other Neurotransmitters & drugs that block or mimic them… (What are those called? Block? Mimic?) Note “alcohol!!” 28 Blood/Brain barrier & N-T’s Lets brain block out unwanted chem. in blood…So some can't sneak thru… Dr’s can't just inject dopamine for Parkinson's (has a shortage of dopamine) b/c blood-brain barrier blocks it… But another substance, L-dopa, can get in… THEN once it’s in, it converts to dopamine, so helps those w/ Parkinsons EX: 29 Facts RE: Dopamine & Parkinson’s: Dopamine is found only in the brain -produced in mid-brain & is chiefly involved in movement & the “reward system” (pleasure) When production slows (like in Parkinson’s), a person has tremors & shuffling movement b/c of loss of dopamine's ability to regulate large movts. Usually also a loss of weight & less interest in sex as there's less dopamine for the pleasure pathways There are dopamine agonists that could treat Parkinson's symptoms, but the problem is getting past the blood-brain barrier. -L-dopa will cross the barrier, but for some reason the brain slowly stops converting L-dopa into dopamine. 30 The Nervous System(s) Nervous System body’s speedy, electrochemical communication system NS = all the nerve cells of the peripheral & central nervous systems Central Nervous System (CNS) brain & spinal cord Peripheral Nervous System (PNS) the sensory (afferent) & motor (efferent) neurons that connect the central nervous system (CNS) to the rest of the body 31 The Nervous System Nervous system Central (brain and spinal cord) Peripheral Autonomic (controls self-regulated action of internal organs and glands) Somatic: (controls voluntary movements of skeletal muscles) Sympathetic (arousing) Parasympathetic (calming) Wants homeostasis 32 The Nervous System Nerves neural “electrical cables” made of neurons …carries info are part of the peripheral nervous system connect the central nervous system with muscles, glands, and sense organs EX: optic nerve for vision, auditory for hearing *Are 3 kinds of neurons in nervous system… 33 The Nervous System 3 types of Neurons: 1) Sensory Neurons (aka afferent): sends info from body's tissues & sensory organs into the brain & Sp. cord for processing -carry incoming info from sense receptors to the CNS 2) Interneurons: in sensory neuron’s processing, these are used by CNS to allow internal commmun. betwn. motor & sensory neurons CNS neurons that internally communicate & intervene between the sensory inputs & motor outputs 3) Motor Neurons (aka efferent): CNS uses these to send instructions back out to the body's tissues carry outgoing information from the CNS to muscles & glands 34 Nervous System: = CNS (brain + sp.cord) PNS 2 main parts... + PNS Somatic Nervous System: voluntary things… the division of the peripheral nervous system that controls the body’s skeletal muscles Autonomic NS: involuntary the part of the peripheral nervous system that controls the glands and the muscles of the internal organs (such as the heart)…. ANS is divided into 2 sections…. Sympathetic NS division of the autonomic nervous system that arouses the body, mobilizing (Spends) its energy in stressful situations Parasympathetic NS (p. 66--functions) division of the autonomic nervous system that calms the body, conserving (Preserves) its energy 35 The Nervous System: Sympathetic nervous system gets you going for physical exertion & exercise OR for emergencies 36 The Nervous System: The ParaSympathetic Nervous System calms you down and brings you back to homeostasis (what is that?) 37 The Nervous System Neural Networks interconnected neural cells Neurons in the brain connect with one another to form networks Inputs Outputs The brain learns by modifying certain connections in response to feedback with experience (learning), networks can learn, as feedback strengthens or inhibits connections that produce certain results computer simulations of neural networks show analogous 38 learning The Nervous System: The spinal cord: Reflex: simple neural paths to the sp-cord: often = 1 sensory neuron + 1 motor neuron "talking thru" a interneuron simple, automatic, inborn response to a sensory stimulus EX: "knee-jerk" …headless warm body could do this! EX2: pain reflex…flame to fingers = auto reflex…in fact, jerks away b4 info actually hits brain Brain Sensory neuron (incoming information) Muscle Motor neuron (outgoing information) Interneuron Spinal cord Skin receptors 39 But if sp-cord severed at top, you'd not feel pain--or pleasure…Would do the knee-jerk, but just wouldn't feel the tap So…Males could get erection & females could auto-lubricate if stimulated…but can’t feel the pleasurable feelings of sex-stim. Neural networks: May put ?’s into the answers Read (on p. 68) & explain this process: a) How is your brain like a computer? b) How do they use Kobe Bryant’s b-ball skills as EX: for this? c) How does Fig. 2.9 show this? Explain this figure d) But how is our brain beyond this simplistic figure? 40 The Brain Lesion: tissue destruction a brain lesion is a naturally or experimentally caused destruction of brain tissue 41 How do the brain & the mind differ? Read p. 69 & we will discuss… B4 PET, electron microscope, etc., How did ppl study the brain? Dead ppl: could look at & dissect…but is the mind there? Brain vs. mind: the old philosp. ? Alive: could use lesions…wounds, damage, disease, etc, & have for 5000 yrs. (EX?) -Only in last 200 yrs began to do it scientifically (E---?) -areas of damage changed behaviors certain ways NOW: can use elec., chem., or magnetic signals to stimulate brain to see effects In animals, can inflict lesions to see effects EX: in hypothalamus: 1 area = starving self to death…another = drastically overeating New ways to study the brain: EEG’s, CT’s, PET’s, MRI’s: 42 Electroencephalogram(EEG) : brain gives off signals that can be picked up various ways…thru EEG's: see brain elec. activity on graph an amplified recording of the waves of electrical activity that sweep across the brain’s surface these waves are measured by electrodes placed on the scalp 43 2 EEG views 44 The Brain today: CT (computed tomography— ”CAT”) Scan: series of x-ray photographs taken from different angles & combined by computer into a composite Representation of a slice thru the body; x-ray photos that show damage PET (positron emission tomography) Scan: More dramatic: Shows use of ionized glucose… Neurons consume glucose as they are being used, so inject radioactive glucose & watch it being used as person does stuff …“while the brain performs a given task” (EX: p. 83, bottom) 45 PET SCANS 5 Activities Parkinson’s/ Norm. 46 MRI (magnetic resonance imaging): Uses magnetic fields to show soft tissues--like very detailed photo (compared to CT) fMRI's (functional MRI's) Special MRI that works by monitoring blood flow Can photogr. activity, like a more detailed PET scan Shows when things happen, how areas change, & how areas work together 47 MRI Scans: Noting ventricles Below: Pituitary 48 These techniques = what the microscope did for biology & telescope for astronomy New discoveries are constantly coming in *Look at bottom of p. 71 for new samples of info Parts of The Brain: Lower brain: Ratio of body wt. to brain wt. ? -capabilities give better view: -primitive vertebrates (EX:shark): breathe, rest, feed…but lower mammals (EX: rats) = more emotion & memory… --even more advanced…humans…have foresight--ability to plan & think ahead 49 The Lower Brain: Brainstem: the oldest part & central core of the brain, beginning where the spinal cord swells as it enters the skull…looks like “walking stick” responsible for automatic survival functions Medulla [muh-DUL-uh] base of the brainstem where sp-cord enters brain controls heartbeat and breathing can cut this from the higher brain & can still breathe & live 50 The Lower Brain (cont’d.): Reticular Formation: nerve network in the brainstem that plays an important role in controlling arousal (aka reticular activation system: RAS) -is higher into stem, above medulla, betwn. our ears…& goes up into the thalamus --responsible for arousal…activity levels: awake? excited? asleep? EX: cat experiments…p. 72 Thalamus [THAL-uh-muss]: 2 (joined) egg- shaped structures at top of brainstem receives all sensory info (except smell) & transmits replies to the cerebellum & medulla (brain’s “relay station for info”) also seems to help w/ keeping us asleep & help us come awake 51 The Lower Brain Pons: middle-”bump” = Facial expressions + Sleep & attention So…thalamus…pons…medulla…& reticular form. goes across it all…( the blue section) 52 The Lower Brain functions = no conscious effort, as is most brain activ. (we know we're seeing, but not how we are seeing…) Cerebellum [sehr-uh-BELLum] the “little brain” attached to the rear of the brainstem automatic (nonverbal) learning & memory but main function = coordinating movement, balance, etc. damage = mov’t. becomes jerky, exaggerated 53 The Brain: moving on up… Limbic System: Doughnut-shaped system of neural structures at the border of the brainstem & cerebral hemispheres associated w/ (not totally responsible for) emotions such as rage, fear & aggression, & drives such as those for food & sex (4 F’s??) also assoc. w/ forming emotional memories includes the hippocampus, amygdala, & hypothalamus. 54 Ch 1 test info on grading Common problems in Ch 1 test: Need more &/or better details—more SPECIFIC (“look in depth”…like how? Type of data collected? “Collect testing info, med. records, family interviews, subject interviews, etc.”) Write in complete sentences—do not just bullet short phrases. To organize info well, may USE A) B) C) etc., but still need to write out Clarify: info is often too vague—comes close but “no cigar…” Be specific 55 Amygdala [ah-MIG-dah-la]: 2 almond-shaped neural clusters that are components of the limbic system & are linked to emotions: anger, joy/pleasure, & fear Influences memory, especially those tied to emotion Hippocampus: Part of limbic system that turns short-term memory into longterm memory so it can be retrieved later Those w/ damaged hippocampus can’t store new memories… …so they live in the past They don’t lose their old memories, however 56 The Brain Hypothalamus neural structure lying below (hypo) the thalamus; directs several maintenance activities -Eating, drinking, & body temperature helps govern the endocrine system via the pituitary (master gland) gland is linked to emotion & the “pleasure centers” (aka “reward centers”…cortex= nucleus accumbens) --these centers seem to have assoc. w/ dopamine release 57 The Limbic System 58 The Limbic System (D-M Arch. #26, Motivation, disc 2) Electrode implanted in “reward center” 59 The Cerebral Cortex: Cerebral Cortex: the intricate fabric of interconnected neural cells that covers the cerebral hemispheres (see p. 77: fig. 2.17) -body’s ultimate control & info processing center……that “wrinkly grey cap…” --if opened w/o folds/wrinkles, would = about size of large pizza Glial Cells: N-S cells (“glue cells”) that… -support -nourish -guide connections -provide myelin -protect neurons -mop up ions & NT’s (“house-keeping cells”) -may help w/ transmitting info & memory 60 61 The Cerebral Cortex: **Be careful w/ saying “…is in this area” …b/c it’s all tied & interrelated!! Frontal Lobes: involved in … -speaking -muscle movements -in making plans & judgments -higher level thinking -contains motor cortex Parietal Lobes: include the sensory (aka “somatosensory”) cortex: sense of body in space Occipital Lobes: include the visual areas, which receive visual information from the opposite visual field; contains visual cortex Temporal Lobes: include the auditory areas: (think “temples”); left hemisphere contains Wernicke’s area & the auditory cortex 62 The Cerebral Cortex 63 The Cerebral Cortex Motor Cortex area at the rear of the frontal lobes that controls voluntary movements Sensory Cortex area at the front of the parietal lobes that registers and processes body sensations 64 The Cerebral Cortex (& the “humunculus”): 65 The Cerebral Cortex Functional MRI (f MRI) scan Shows the visual cortex activated as the subject looks at faces 66 Phrenology: 1800’s: The “science” that wasn’t Bumps were thought to indicate character traits & abilities Was not tested scientifically …BUT…it did lead to idea of specific abilities in certain brain regions 67 Brain Basics 68 Some brain areas are “uncommitted” areas…But some are “dedicated” …like Visual & Auditory Cortex 69 Association Areas More intelligent animals have increased“uncommitted” or association areas of the cortex:Extra memory banks Discov. Psych: Prg. 25: Cognitive Neuroscience: Phineas Gage Measuring brain’s activity Vision; retinal-topic mapping 70 The Cerebral Cortex: When things go wrong…what is affected? Aphasia Impairment of language, usually caused by left hemisphere damage either to Broca’s area (impairing speaking) or to Wernicke’s area (impairing understanding) Broca’s Area: actually speaking an area of the left frontal lobe that directs the muscle movements involved in speech Wernicke’s Area: understand & think of a response an area of the left temporal lobe involved in language comprehension & expression 71 QUICK QUIZ!!!!!! Ck. yrself… • 1. The molecular shape of some drugs prevents them from passing thru the ______ ______ • 2. The CNS sends messages TO the body’s tissues by means of __ ___. • 3) Info comes into the CNS from the body by means of __ __. • 4) The ____ division of the autonomic system produces relaxation & brings the body back to homeostasis. (Write at bottom!!) • 5) At the top of the brain is the ____ which serves as the brain’s “switchboard” to the areas of the brain. • 6) The ability of the brain to repair itself is known as _____. • 7) Between the brainstem & the cerebral hemispheres is the ____ system. • 8) (See # 7) One part of this system that processes memory is known as the ___ ___. • 9) The non-neural cells that support, protect, & nourish cortical neurons are called ____ cells. • #10) 11) 12) & 13): In alphabetical order….what are the 4 lobes of the brain? 72 Specialization & Integration: “Dedicated” areas (dedicated = “wired” for specific type of info) 73 Specialization & Integration Brain activity when hearing, seeing, & speaking words 74 75 76 Brain Reorganization Plasticity The brain’s capacity for modification, as evident in brain reorganization following damage (especially in children) & in experiments on the effects of experience on brain development Brain reorganizes info areas… 77 PRUNING: 1) “Use it …OR Lose it!” Pruning the unused neurons (“data storage area” or ... Association area) 2) Neural Networks: How neurons form collections of connections & can lead to a “train of thought…” EX: Apple??? 78 Our Divided Brain Corpus callosum Corpus Callosum large band of neural fibers connects the two brain hemispheres carries messages between the hemispheres 79 Our Divided Brain The information highway from the eye to the brain 80 Split Brain a condition in which the two hemispheres of the brain are isolated by cutting the connecting fibers (mainly those of the corpus callosum) between them (1st in 1961) (vid.: Sci. Am. ) 81 Split Brain or 2 words separated by a dot are momentarily projected. 82 Hemispheres: Lateralization Split brain shows different functions…left controls rt., rt. controls left But…vision doesn’t change b/c….? Hemispheric dominance: For about 10% of total population, right hemisph. controls speech, etc. (but 25% of left-handed folks) --can put 1 hemisph. to sleep & look at behaviors in other Some...NOT ALL...hemispheric functions 83 LEFT BRAIN Speech Language Logic, sequence Writing Math (arithmetic, algebra) Hearing hi tones Broca’s & Wernicke’s Language Areas l RIGHT BRAIN . Spatial reasoning Art Music Geometry Emotions Recognizing faces Hearing low tones 84 brilliantabacus.com/images/Brain_Functions_Pi 85 Handedness: (+ -) 10% = left-handed -slightly more males A human trait…most other primates 50/50… Chimps & gorillas = about 35% L Left-handed: In past it = Chimp gets termites w/ left-hand a negative trait (gauche, etc) -more reading disabilities, migraines, allergies BUT… more musicians, artists, certain ball-players, mathematicians…& tends to disappear w/ age 86 Disappearing Southpaws The % of left-handers decreases sharply in samples of older people (adapted from Coren, 1993). Read pp. 90-91 & summarize: Why did some think this was happening? Who disagreed? Who got angry & why? Goes into writing folders…. Percentage of 14% left-handedness 12 10 The percentage of lefties sharply declines with age 8 6 4 2 0 10 20 30 40 50 60 Age in years 70 80 90 87 Summary: Brain Structures & their Functions 88 Endocrine System the body’s “slow” chemical communication system (Which is FASTER system???) a set of glands that secrete hormones into the bloodstream influence growth, reproduction, 89 metabolism & mood Hormones chemical messengers…mostly those manufactured by the endocrine glands produced in 1 tissue & affect another Gonads: Ovaries in females (estrogen & progesterone) Testes in males (mainly testosterone, a type of androgen that affects production of male sex traits) Pituitary Gland under the influence of the hypothalamus, the pituitary regulates growth & controls other endocrine glands: “master gland” hGH: human growth hormone (see BIG article) 90 aka somatotrophine Gigantism & Dwarfism: Problems in the pituitary gland Click for Video Below: Leonid Stadnik Ukrainian with Gigantism 91 92 Adrenal [ah-DREEN-el] Glands a pair of endocrine glands just above the kidneys secrete the hormones epinephrine (adrenaline) & helps to arouse the body in times of stress (F—F??) -norepinephrine (aka noradrenaline): calms back down/homeostasis; helps with mood, etc. Adrenal glands also produce cortical steroids for strength and muscle building The HULK??? Endocrine system works w/ “feedback system” brain pituitary other glands hormones brain *Be sure to make note (p. 95) of all the other glands & their functions from diagram 93 Endocrine system’s “feedback”… Epinephrine (aka??) & Estrogen/Progesterone 94 95 Summary: Remember… everything psychological is ___?____ And although sci. have learned tremendous amts., what we still don’t know is way more than what we know. Psych study has gone from phrenology—which did make scientist start looking at the idea that certain areas of the brain were associated w/ certain functions—to neuroscience -will continue w/ biological aspects with next chapter, Genetics & Behaviors: Nature vs. Nurture 96 Read & Respond: Read pp. 92-93: Left/Right Brain? Respond (paragraph form) w/ min. 3-4 sentences for each item below A) What do people mean by left brained? right brained? B) Why is this an exaggeration? C) Explain the problems with info in the media that goes “...from scientist to reader.” D) Then why does the author caution students to “…not discount everything 97 you read?” F. Neurotransmitters: Name that N-T!!!!!! 1. controls muscle action + involuntary mov’t (heart, etc.); joints -possible memory & arousal -poison works to block, etc. 2. voluntary mov’t -atten. & basic learn. -too little = Parkinson’s too much = schizophrenia 3. mood; also pain control… -control of eating, sleep, & arousal; maybe dreaming -too much = mania; too little = depress. 4. alertness, wakefulness…& mood (related to depres.) 5. sleep, eating disorders; too much can = migraines 6. pain sensation, mood: happiness, feel good, “sense of well-being”, etc.; chem. related to opiates 7. inhibitory NT that affects seizures, tremors, & insomnia 98 CH 2 (cont.’d) MATCH each! -thalamus *Limbic system: -medulla -pons -amygdala -hippocampus -hypothalamus -reticular formation -cerebellum 1. change STM LTM 2.thirst, hunger & sex drives + aggression + reward ctr. 3. activity levels; attention 4. controls “4 F’s” 5. balance & some classic. condi. + dexterity 6.emotions, aggression, fear 7.breathing & heart-rate 8.“switch board” of the brain 9. facial expressions 99 Endocrine system match-up: -Adrenal glands -Pituitary gland -Pancreas -Thyroid -pineal gland -gonads 1. set point; metabolism 2. fight/flight; stress 3. hGh (somatotrophine) & master gland 4. puberty; sex hormones 5. maintains glucose levels 100