MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
MMP-2 inhibits PCSK9-induced degradation of the LDLR in Hepa1-c1c7 cells
Xiang Wang(1,6), Evan Berry(1,6), Samuel Hernandez-Anzaldo(1,6), Difei Sun(2,7), Ayinuer
Adijiang(3,6), Liang Li(2,7), Dawei Zhang(1,3,6), and Carlos Fernandez-Patron(1,4,5,6)
Departments of Biochemistry (1),
Chemistry (2),
Group on Molecular and Cell Biology of Lipids (3)
Mazankowski Alberta Heart Institute (4)
Cardiovascular Research Group (5)
Faculty of Medicine and Dentistry (6)
Faculty of Science (7)
University of Alberta
Edmonton, Alberta, Canada
Correspondence:
Carlos Fernandez-Patron (cf2@ualberta.ca)
Associate Professor
3-19 Medical Sciences Building
Department of Biochemistry
Mazankowski Alberta Heart Institute
Cardiovascular Research Group
Faculty of Medicine and Dentistry
University of Alberta
Edmonton, AB T6G 2H7
CANADA
Tel: 780-492-9540 (office)
Tel: 780-492-7618 (lab)
1
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
*
mRNA expression
(% of AdGFP)
250
200
150
100
50
0
Sr
*
*
*
*
r
f2
gc
eb
Hm
*
lr
1
2
3
2
Ld nsig nsig
1h
1h
I
I
Nr
Nr
AdGFP
AdMMP2
Supplementary Figure 1: Effect of MMP-2 overexpression on mRNA levels of lipid metabolic
genes as determined by qRT-PCR analysis. The figure shows that MMP-2 overexpression causes
a downregulation of SREBP-2 and target genes. Other transcription factors such as Nr1h2 and
Nr1h3 (which encode LXR-β and LXR-α, respectively) are inversely regulated. Results are
mean±sem. n = 4. *: p<0.05 vs. AdGFP (vehicle).
2
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
sp|Q80W65|PCSK9_MOUSE Proprotein convertase subtilisin/kexin type 9 OS=Mus musculus
GN=Pcsk9 PE=1 SV=2
MGTHCSAWLRWPLLPLLPPLLLLLLLLCPTGAGAQDEDGDYEELMLALPSQEDGLADEAA
HVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYD
LFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGS
SQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGR
DAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRIL
NAACRHLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGR
CVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAAHVAGIVARMLSREPTLTLAELRQRLIH
FSTKDVINMAWFPEDQQVLTPNLVATLPPSTHETGGQLLCRTVWSAHSGPTRTATATARC
APEEELLSCSSFSRSGRRRGDWIEAIGGQQVCKALNAFGGEGVYAVARCCLVPRANCSIH
NTPAARAGLETHVHCHQKDHVLTGCSFHWEVEDLSVRRQPALRSRRQPGQCVGHQAASVY
ASCCHAPGLECKIKEHGISGPSEQVTVACEAGWTLTGCNVLPGASLTLGAYSVDNLCVAR
VHDTARADRTSGEATVAAAICCRSRPSAKASWVQ
Supplementary Figure 2: Matrix assisted laser desorption ionization-time of flight (MALDITOF) mass spectroscopy of recombinant mouse (rm) PCSK9 after digestion for 16 hrs at 37C
with APMA-activated recombinant human (rh) pro-MMP-2. The analysis suggested two putative
cleavage sites both occurring at GlyIle bonds that would yield peptides with the experimentally
observed masses values of 33174.81 Da (red + green) and 22757.56 Da (red). A peptide with
mass of 8620.60 Da (green) was observed as well. The experiment was performed using mouse
PCSK9 and recombinant human MMP-2. The prodomain sequence is underlined. The AlaIle
cleavage site is predicted from the analysis of human PCSK9 (Supplementary Table 1).
Detailed MALDI-TOF data is found in Supplementary Table 2.
3
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
Supplementary Figure 3: LDLR positive cells were transduced with either AdGFP or AdMMP2 to overexpress MMP-2. 24 hours later, the medium was replaced by media without serum. 16
hours later, the pharmacological MMP-2 inhibitor III (40 μmol/L) or vehicle was added to the
cells. 1 hour later, rhPCSK9 was added to the cells. 4 hours later, the cells were collected and
lysed, The lysates were subjected to western blot with LDLR antibodies. Partial LDLR
protection by MMP-2 was observed even in the presence of MMP-2 inhibitor III. *: p <0.05 vs.
AdGFP (vehicle). n=3-4 / group.
4
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
Supplementary Table 1 List of peptides identified by LC-MS/MS analysis of in-gel microwaveassisted acid hydrolysis products of PCSK9 prodomain cleavage fragment.
Matched peptides shown in Bold Red
QEDEDGDYEE LVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVV
VLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDL
LELALKLPHVDYIEEDSSVFAQ
Start - End
15 - 27
15 - 28
15 - 29
15 - 29
15 - 32
15 - 38
score 15)
15 - 39
score 36)
15 - 40
score 31)
15 - 40
score 25)
19 - 29
20 - 29
21 - 35
21 - 39
21 - 40
41 - 45
41 - 46
41 - 46
41 - 47
41 - 48
41 - 53
43 - 53
43 - 55
44 - 55
45 - 52
45 - 55
45 - 55
46 - 55
47 - 54
47 - 55
47 - 55
47 - 55
47 - 55
47 - 56
47 - 57
47 - 57
47 - 58
47 - 58
47 - 58
47 - 58
47 - 59
Observed Mr(expt) Mr(calc)
708.3392 1414.6638 1414.6576
518.2374 1551.6904 1551.7165
805.3794 1608.7442 1608.7379
537.2596 1608.7570 1608.7379
628.3018 1881.8836 1881.8704
664.5649 2654.2305 2654.2143
ppm
4
-17
4
12
7
Miss
Sequence
0 A.LRSEEDGLAEAPE.H (Ions score 46)
0 A.LRSEEDGLAEAPEH.G (Ions score 30)
0 A.LRSEEDGLAEAPEHG.T (Ions score 34)
0 A.LRSEEDGLAEAPEHG.T (Ions score 23)
0 A.LRSEEDGLAEAPEHGTTA.T (Ions score 30)
6
0 A.LRSEEDGLAEAPEHGTTATFHRCA.K (Ions
696.5886 2782.3253 2782.3093
6
0 A.LRSEEDGLAEAPEHGTTATFHRCAK.D (Ions
725.3466 2897.3573 2897.3362
7
0 A.LRSEEDGLAEAPEHGTTATFHRCAKD.P (Ions
725.3492 2897.3677 2897.3362
11
0 A.LRSEEDGLAEAPEHGTTATFHRCAKD.P (Ions
562.7459 1123.4772 1123.4782
498.2356 994.4566 994.4356
513.5804 1537.7194 1537.7161
514.2590 2053.0069 2052.9799
723.6776 2168.0110 2168.0069
334.6987 667.3828 667.3806
725.4178 724.4105 724.4020
363.2128 724.4110 724.4020
413.7353 825.4560 825.4497
495.2643 988.5140 988.5130
509.9779 1526.9119 1526.8973
622.8951 1243.7756 1243.7652
751.9345 1501.8544 1501.8504
673.8861 1345.7576 1345.7493
847.4999 846.4926 846.4851
617.3485 1232.6824 1232.6653
1233.7047 1232.6974 1232.6653
568.8229 1135.6312 1135.6125
950.5647 949.5574 949.5484
1079.5810 1078.5737 1078.5910
540.3074 1078.6002 1078.5910
1079.6105 1078.6032 1078.5910
540.3099 1078.6052 1078.5910
1180.6616 1179.6543 1179.6387
659.3600 1316.7054 1316.6976
439.9098 1316.7076 1316.6976
715.9019 1429.7892 1429.7817
715.9032 1429.7918 1429.7817
477.6062 1429.7968 1429.7817
477.6089 1429.8049 1429.7817
759.4209 1516.8272 1516.8137
-1 0 E.EDGLAEAPEHG.T (Ions score 15)
21 0 E.DGLAEAPEHG.T (Ions score 20)
2 0 D.GLAEAPEHGTTATFH.R (Ions score 13)
13 0 D.GLAEAPEHGTTATFHRCAK.D (Ions score 19)
2 0 D.GLAEAPEHGTTATFHRCAKD.P (Ions score 25)
3 0 D.PWRLP.G (Ions score 18)
12 0 D.PWRLPG.T (Ions score 14)
12 0 D.PWRLPG.T (Ions score 21)
8 0 D.PWRLPGT.Y (Ions score 15)
1 0 D.PWRLPGTY.V (Ions score 18)
10 0 D.PWRLPGTYVVVLK.E (Ions score 25)
8 0 W.RLPGTYVVVLK.E (Ions score 24)
3 0 W.RLPGTYVVVLKEE.T (Ions score 31)
6 0 R.LPGTYVVVLKEE.T (Ions score 58)
9 0 L.PGTYVVVL.K (Ions score 17)
14 0 L.PGTYVVVLKEE.T (Ions score 39)
26 0 L.PGTYVVVLKEE.T (Ions score 24)
17 0 P.GTYVVVLKEE.T (Ions score 36)
9 0 G.TYVVVLKE.E (Ions score 24)
-16 0 G.TYVVVLKEE.T (Ions score 39)
9 0 G.TYVVVLKEE.T (Ions score 14)
11 0 G.TYVVVLKEE.T (Ions score 18)
13 0 G.TYVVVLKEE.T (Ions score 53)
13 0 G.TYVVVLKEET.H (Ions score 28)
6 0 G.TYVVVLKEETH.L (Ions score 33)
8 0 G.TYVVVLKEETH.L (Ions score 43)
5 0 G.TYVVVLKEETHL.S (Ions score 56)
7 0 G.TYVVVLKEETHL.S (Ions score 33)
11 0 G.TYVVVLKEETHL.S (Ions score 38)
16 0 G.TYVVVLKEETHL.S (Ions score 14)
9 0 G.TYVVVLKEETHLS.Q (Ions score 28)
5
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
47 - 60
823.9393 1645.8640 1645.8563
score 34)
47 - 60
823.9457 1645.8768 1645.8563
score 36)
47 - 63
673.6873 2018.0401 2018.0320
(Ions score 58)
59 - 76
512.0271 2044.0793 2044.0521
(NQ) (Ions score 21)
77 - 85
567.3436 1132.6726 1132.6645
77 - 85
378.5659 1132.6759 1132.6645
77 - 86
635.8766 1269.7386 1269.7234
77 - 86
635.8767 1269.7388 1269.7234
77 - 87
664.3871 1326.7596 1326.7448
77 - 87
664.3874 1326.7602 1326.7448
77 - 87
664.3877 1326.7608 1326.7448
79 - 86
332.1994 993.5764 993.5760
79 - 91
716.4277 1430.8408 1430.8398
79 - 91
716.4278 1430.8410 1430.8398
81 - 91
601.8560 1201.6974 1201.6972
86 - 95
540.8341 1079.6536 1079.6492
86 - 96
606.3616 1210.7086 1210.6896
86 - 96
614.3541 1226.6936 1226.6846
86 - 97
657.8685 1313.7224 1313.7166
17)
86 - 98
686.3815 1370.7484 1370.7381
28)
87 - 96
545.8290 1089.6434 1089.6256
87 - 98
617.8545 1233.6944 1233.6791
49)
87 - 98
617.8551 1233.6956 1233.6791
48)
88 - 97
552.8310 1103.6474 1103.6413
88 - 98
589.3408 1176.6670 1176.6577
89 - 95
773.5010 772.4937 772.4847
89 - 96
452.7703 903.5260 903.5252
89 - 96
460.7707 919.5268 919.5201
89 - 97
496.2884 990.5622 990.5572
89 - 98 1048.5946 1047.5873 1047.5787
89 - 98
524.8014 1047.5882 1047.5787
89 - 98
532.8002 1063.5858 1063.5736
90 - 95
660.4127 659.4054 659.4007
90 - 95
330.7106 659.4066 659.4007
90 - 95
660.4166 659.4093 659.4007
90 - 96
791.4514 790.4441 790.4411
90 - 96
791.4560 790.4487 790.4411
90 - 96
404.2278 806.4410 806.4361
90 - 96
807.4555 806.4482 806.4361
90 - 98
468.2598 934.5050 934.4946
97 - 106 1058.6117 1057.6044 1057.6019
97 - 106 529.8137 1057.6128 1057.6019
98 - 106 486.2919 970.5692 970.5699
99 - 105 786.4677 785.4604 785.4534
99 - 106 457.7831 913.5516 913.5484
99 - 106 914.5659 913.5586 913.5484
100 - 106 400.2675 798.5204 798.5215
100 - 106 799.5364 798.5291 798.5215
5
0 G.TYVVVLKEETHLSQ.S Deamidated (NQ) (Ions
12
0 G.TYVVVLKEETHLSQ.S Deamidated (NQ) (Ions
4
0 G.TYVVVLKEETHLSQSER.T Deamidated (NQ)
13
7
10
12
12
11
12
12
0
1
1
0
4
16
7
0 L.SQSERTARRLQAQAARRG.Y 3 Deamidated
0 G.YLTKILHVF.H (Ions score 40)
0 G.YLTKILHVF.H (Ions score 15)
0 G.YLTKILHVFH.G (Ions score 68)
0 G.YLTKILHVFH.G (Ions score 75)
0 G.YLTKILHVFHG.L (Ions score 78)
0 G.YLTKILHVFHG.L (Ions score 73)
0 G.YLTKILHVFHG.L (Ions score 64)
0 L.TKILHVFH.G (Ions score 17)
0 L.TKILHVFHGLLPG.F (Ions score 22)
0 L.TKILHVFHGLLPG.F (Ions score 29)
0 K.ILHVFHGLLPG.F (Ions score 39)
0 F.HGLLPGFLVK.M (Ions score 43)
0 F.HGLLPGFLVKM.S (Ions score 27)
0 F.HGLLPGFLVKM.S Oxidation (M) (Ions score 50)
4 0 F.HGLLPGFLVKMS.G Oxidation (M) (Ions score
8
0 F.HGLLPGFLVKMSG.D Oxidation (M) (Ions score
16 0 H.GLLPGFLVKM.S Oxidation (M) (Ions score 35)
12 0 H.GLLPGFLVKMSG.D Oxidation (M) (Ions score
13
0 H.GLLPGFLVKMSG.D Oxidation (M) (Ions score
6 0 G.LLPGFLVKMS.G (Ions score 23)
8 0 G.LLPGFLVKMSG.D Oxidation (M) (Ions score 28)
12 0 L.LPGFLVK.M (Ions score 15)
1 0 L.LPGFLVKM.S (Ions score 27)
7 0 L.LPGFLVKM.S Oxidation (M) (Ions score 27)
5 0 L.LPGFLVKMS.G (Ions score 22)
8 0 L.LPGFLVKMSG.D (Ions score 23)
9 0 L.LPGFLVKMSG.D (Ions score 36)
12 0 L.LPGFLVKMSG.D Oxidation (M) (Ions score 32)
7 0 L.PGFLVK.M (Ions score 20)
9 0 L.PGFLVK.M (Ions score 15)
13 0 L.PGFLVK.M (Ions score 22)
4 0 L.PGFLVKM.S (Ions score 15)
10 0 L.PGFLVKM.S (Ions score 17)
6 0 L.PGFLVKM.S Oxidation (M) (Ions score 19)
15 0 L.PGFLVKM.S Oxidation (M) (Ions score 16)
11 0 L.PGFLVKMSG.D (Ions score 17)
2 0 M.SGDLLELALK.L (Ions score 40)
10 0 M.SGDLLELALK.L (Ions score 66)
-1 0 S.GDLLELALK.L (Ions score 18)
9 0 G.DLLELAL.K (Ions score 22)
4 0 G.DLLELALK.L (Ions score 32)
11 0 G.DLLELALK.L (Ions score 32)
-1 0 D.LLELALK.L (Ions score 32)
10 0 D.LLELALK.L (Ions score 27)
6
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
100 - 106 799.5389 798.5316 798.5215
101 - 106 686.4523 685.4450 685.4374
101 - 111 624.3684 1246.7222 1246.7285
102 - 116 892.4559 1782.8972 1782.9039
107 - 116 615.2934 1228.5722 1228.5612
107 - 116 1229.5891 1228.5818 1228.5612
107 - 117 658.8066 1315.5986 1315.5932
108 - 116 1116.4860 1115.4787 1115.4771
108 - 116 558.7541 1115.4936 1115.4771
108 - 122 868.8883 1735.7620 1735.7577
score 70)
13 0 D.LLELALK.L (Ions score 16)
11 0 L.LELALK.L (Ions score 21)
-5 0 L.LELALKLPHVD.Y (Ions score 26)
-4 0 L.ELALKLPHVDYIEED.S (Ions score 16)
9 0 K.LPHVDYIEED.S (Ions score 36)
17 0 K.LPHVDYIEED.S (Ions score 34)
4 0 K.LPHVDYIEEDS.S (Ions score 21)
1 0 L.PHVDYIEED.S (Ions score 29)
15 0 L.PHVDYIEED.S (Ions score 18)
3 0 L.PHVDYIEEDSSVFAQ.- Deamidated (NQ) (Ions
7
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
Supplementary Table 2 List of peptides identified by MALDI-TOF MS analysis of rmPCSK9
cleavage fragments after 16 hrs at 37C with rhMMP-2 (PCSK9:MMP-2 = 10:1; mol:mol).
Molecular weights from 8000 - 100000 Da were generated using SA as the matrix
Molecular weights from 500 - 8000 Da were generated using ACH as the matrix.
Matched peptides shown in Bold Red
Index
Centroid Mass
Lower
Bound
Upper
Bound
Charge
(z)
Height
Relative
intensity
Area
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
8003.35273
8010.22506
8016.95363
8033.39634
8045.59378
8070.0824
8095.82056
8116.67446
8129.89402
8145.44661
8152.57061
8170.84332
8184.51132
8193.43533
8218.53951
8237.34411
8245.89366
8263.06146
8277.95137
8286.6256
8313.72245
8324.31284
8334.92649
8355.8099
8372.639
8396.16453
8413.8471
8429.58411
8438.94195
8460.16717
8478.50042
8498.107
8003.35
8010.23
8016.95
8033.4
8045.59
8070.08
8095.82
8116.67
8129.89
8145.45
8152.57
8170.84
8184.51
8193.44
8218.54
8237.34
8245.89
8263.06
8277.95
8286.63
8313.72
8324.31
8334.93
8355.81
8372.64
8396.16
8413.85
8429.58
8438.94
8460.17
8478.5
8498.11
8003.35
8010.23
8016.95
8033.4
8045.59
8070.08
8095.82
8116.67
8129.89
8145.45
8152.57
8170.84
8184.51
8193.44
8218.54
8237.34
8245.89
8263.06
8277.95
8286.63
8313.72
8324.31
8334.93
8355.81
8372.64
8396.16
8413.85
8429.58
8438.94
8460.17
8478.5
8498.11
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
4632
6196
15467
9094
18442
60391
27435
19856
4590
13595
4102
18865
5235
5948
63811
7877
5912
22540
3156
24456
18124
9995
29247
26734
32866
16210
14358
7028
12738
34149
10800
21227
7.15
9.56
23.87
14.03
28.46
93.18
42.33
30.64
7.08
20.98
6.33
29.11
8.08
9.18
98.46
12.15
9.12
34.78
4.87
37.74
27.97
15.42
45.13
41.25
50.71
25.01
22.15
10.84
19.65
52.69
16.66
32.75
4631.7
6195.65
15467.3
9094.22
18442.28
60390.67
27435.29
19855.86
4589.53
13594.5
4101.58
18864.65
5235.22
5947.5
63811.45
7876.98
5911.74
22540.15
3156.41
24456.1
18124.11
9995.47
29247.13
26734.12
32866.28
16209.99
14358.07
7027.92
12737.93
34148.55
10800.11
21227.1
8
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
8510.36238
8526.23572
8539.11436
8570.55283
8589.48764
8603.17631
8620.64271
8652.75515
8670.67744
8691.62197
8708.71323
8728.47055
8746.19293
8762.32244
8788.88674
8810.08045
8831.13589
8854.36404
8863.73201
8876.50075
8894.03704
8912.53927
8929.67705
8951.70734
8964.57592
8988.46859
9022.37345
9036.11506
9045.78323
9059.78364
9084.98272
9103.64497
9114.25136
9122.91948
9142.26181
9157.0637
9170.96119
9178.73357
9197.94731
9228.8384
9246.83811
9262.06287
9274.96254
8510.36
8526.24
8539.11
8570.55
8589.49
8603.18
8620.64
8652.76
8670.68
8691.62
8708.71
8728.47
8746.19
8762.32
8788.89
8810.08
8831.14
8854.36
8863.73
8876.5
8894.04
8912.54
8929.68
8951.71
8964.58
8988.47
9022.37
9036.12
9045.78
9059.78
9084.98
9103.64
9114.25
9122.92
9142.26
9157.06
9170.96
9178.73
9197.95
9228.84
9246.84
9262.06
9274.96
8510.36
8526.24
8539.11
8570.55
8589.49
8603.18
8620.64
8652.76
8670.68
8691.62
8708.71
8728.47
8746.19
8762.32
8788.89
8810.08
8831.14
8854.36
8863.73
8876.5
8894.04
8912.54
8929.68
8951.71
8964.58
8988.47
9022.37
9036.12
9045.78
9059.78
9084.98
9103.64
9114.25
9122.92
9142.26
9157.06
9170.96
9178.73
9197.95
9228.84
9246.84
9262.06
9274.96
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7408
19087
28528
13792
7856
16812
26962
27883
24833
64809
8442
30938
16413
18244
29050
14801
36291
14221
9869
7910
6828
10787
8073
23459
16560
10863
14021
1608
16118
8158
19494
5097
1609
3571
4448
11439
7333
17883
22113
12189
12411
7214
3558
11.43
29.45
44.02
21.28
12.12
25.94
41.6
43.02
38.32
100
13.03
47.74
25.33
28.15
44.82
22.84
56
21.94
15.23
12.21
10.54
16.64
12.46
36.2
25.55
16.76
21.63
2.48
24.87
12.59
30.08
7.86
2.48
5.51
6.86
17.65
11.31
27.59
34.12
18.81
19.15
11.13
5.49
7408.48
19086.93
28527.91
13792.3
7855.64
16812.47
26962.33
27882.68
24832.99
64809.25
8441.59
30937.86
16413.1
18243.59
29049.83
14800.96
36291.39
14220.53
9869.48
7910.14
6827.76
10787.19
8073.38
23458.91
16560.46
10863.25
14020.68
1608.31
16118.38
8157.98
19494.38
5096.86
1608.62
3571.29
4448.16
11439.35
7332.64
17882.54
22113.16
12189.45
12410.55
7214.18
3558.43
9
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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9287.38054
9306.73332
9340.49727
9361.96168
9383.44023
9404.00473
9426.5684
9440.47546
9460.09092
9473.22975
9495.29395
9511.55071
9532.31265
9548.88833
9574.61414
9584.30016
9608.13013
9625.6835
9645.10138
9661.24299
9685.04718
9694.30653
9708.72275
9721.25605
9747.57377
9783.92179
9804.93948
9819.09378
9838.86977
9856.83684
9873.21816
9896.6643
9917.38553
9934.84508
9960.55045
9979.54127
9992.75229
10011.34519
10029.16877
10041.3677
10060.77819
10082.05081
10099.39538
9287.38
9306.73
9340.5
9361.96
9383.44
9404
9426.57
9440.48
9460.09
9473.23
9495.29
9511.55
9532.31
9548.89
9574.61
9584.3
9608.13
9625.68
9645.1
9661.24
9685.05
9694.31
9708.72
9721.26
9747.57
9783.92
9804.94
9819.09
9838.87
9856.84
9873.22
9896.66
9917.39
9934.85
9960.55
9979.54
9992.75
10011.35
10029.17
10041.37
10060.78
10082.05
10099.4
9287.38
9306.73
9340.5
9361.96
9383.44
9404
9426.57
9440.48
9460.09
9473.23
9495.29
9511.55
9532.31
9548.89
9574.61
9584.3
9608.13
9625.68
9645.1
9661.24
9685.05
9694.31
9708.72
9721.26
9747.57
9783.92
9804.94
9819.09
9838.87
9856.84
9873.22
9896.66
9917.39
9934.85
9960.55
9979.54
9992.75
10011.35
10029.17
10041.37
10060.78
10082.05
10099.4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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0
0
0
0
11597
19807
26043
12530
36023
21095
37315
31475
12058
17383
5782
16557
11292
20091
15467
2919
10146
13819
19790
8492
12063
3176
2883
13490
17721
14870
15169
8294
25825
6900
17476
37854
10992
18826
9592
4770
5833
6822
8313
8249
19938
4037
15397
17.89
30.56
40.18
19.33
55.58
32.55
57.58
48.57
18.6
26.82
8.92
25.55
17.42
31
23.87
4.5
15.65
21.32
30.54
13.1
18.61
4.9
4.45
20.82
27.34
22.94
23.41
12.8
39.85
10.65
26.97
58.41
16.96
29.05
14.8
7.36
9
10.53
12.83
12.73
30.76
6.23
23.76
11597.26
19807.26
26042.6
12529.95
36022.66
21094.57
37314.59
31474.75
12057.71
17382.87
5781.72
16557.02
11292.11
20090.95
15467.34
2919.47
10145.65
13819.06
19789.72
8492.29
12063.31
3176.01
2883.25
13490.35
17721.03
14870.16
15169.49
8294.11
25824.69
6900.49
17475.96
37853.73
10992.29
18826.42
9591.63
4769.6
5833.15
6821.93
8313.07
8248.98
19937.62
4036.77
15397.35
10
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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10136.70459
10171.75991
10189.56144
10200.35178
10220.29065
10239.1736
10279.31273
10306.83387
10329.82334
10341.08613
10369.66989
10378.28469
10415.07128
10426.87063
10476.35056
10507.61526
10520.12994
10533.38072
10544.9019
10557.73051
10565.33212
10589.3416
10607.33715
10631.97694
10669.67203
10692.54594
10712.52651
10734.80417
10751.63845
10767.81661
10787.6157
10819.81882
10847.24943
10863.67585
10879.00825
10891.62926
10922.01733
10947.03634
10970.54142
10990.32787
11018.29959
11042.74422
11059.15092
10136.7
10171.76
10189.56
10200.35
10220.29
10239.17
10279.31
10306.83
10329.82
10341.09
10369.67
10378.28
10415.07
10426.87
10476.35
10507.62
10520.13
10533.38
10544.9
10557.73
10565.33
10589.34
10607.34
10631.98
10669.67
10692.55
10712.53
10734.8
10751.64
10767.82
10787.62
10819.82
10847.25
10863.68
10879.01
10891.63
10922.02
10947.04
10970.54
10990.33
11018.3
11042.74
11059.15
10136.7
10171.76
10189.56
10200.35
10220.29
10239.17
10279.31
10306.83
10329.82
10341.09
10369.67
10378.28
10415.07
10426.87
10476.35
10507.62
10520.13
10533.38
10544.9
10557.73
10565.33
10589.34
10607.34
10631.98
10669.67
10692.55
10712.53
10734.8
10751.64
10767.82
10787.62
10819.82
10847.25
10863.68
10879.01
10891.63
10922.02
10947.04
10970.54
10990.33
11018.3
11042.74
11059.15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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0
48185
10016
5625
9368
4523
18570
11277
17700
7870
10810
7061
10983
5352
10960
34003
7563
11924
3759
10781
3366
7123
11561
4378
26043
27171
6699
15288
7950
7751
5128
22294
6042
7768
7806
4920
5730
10268
5133
22460
6246
16352
3257
4845
74.35
15.46
8.68
14.46
6.98
28.65
17.4
27.31
12.14
16.68
10.89
16.95
8.26
16.91
52.47
11.67
18.4
5.8
16.64
5.19
10.99
17.84
6.76
40.18
41.93
10.34
23.59
12.27
11.96
7.91
34.4
9.32
11.99
12.05
7.59
8.84
15.84
7.92
34.66
9.64
25.23
5.03
7.48
48185.03
10016.31
5624.98
9368.46
4522.89
18569.93
11276.97
17699.69
7869.95
10810.27
7060.81
10983.34
5351.74
10959.88
34003.07
7563.4
11924.02
3759.18
10781.09
3366.2
7123.46
11560.97
4378.07
26042.96
27171.5
6698.8
15288.2
7950.15
7751.02
5127.58
22293.63
6041.65
7767.53
7806.32
4919.54
5730.23
10268.31
5132.82
22460.12
6245.73
16351.59
3256.71
4845.4
11
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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11070.80027
11091.8824
11117.23114
11125.9473
11149.3371
11182.57481
11198.90635
11231.98873
11276.54465
11309.07885
11333.73336
11375.92264
11410.33782
11435.93991
11458.46926
11470.08405
11483.79908
11498.98029
11525.67447
11546.96109
11573.88793
11593.18122
11640.24732
11671.21429
11690.37788
11721.28212
11734.03125
11758.24447
11785.50245
11815.651
11832.36911
11855.94008
11879.26717
11911.31743
11942.53242
11954.01055
11989.65874
12010.17327
12049.67256
12062.32242
12106.96346
12130.01001
12153.0532
11070.8
11091.88
11117.23
11125.95
11149.34
11182.57
11198.91
11231.99
11276.54
11309.08
11333.73
11375.92
11410.34
11435.94
11458.47
11470.08
11483.8
11498.98
11525.67
11546.96
11573.89
11593.18
11640.25
11671.21
11690.38
11721.28
11734.03
11758.24
11785.5
11815.65
11832.37
11855.94
11879.27
11911.32
11942.53
11954.01
11989.66
12010.17
12049.67
12062.32
12106.96
12130.01
12153.05
11070.8
11091.88
11117.23
11125.95
11149.34
11182.57
11198.91
11231.99
11276.54
11309.08
11333.73
11375.92
11410.34
11435.94
11458.47
11470.08
11483.8
11498.98
11525.67
11546.96
11573.89
11593.18
11640.25
11671.21
11690.38
11721.28
11734.03
11758.24
11785.5
11815.65
11832.37
11855.94
11879.27
11911.32
11942.53
11954.01
11989.66
12010.17
12049.67
12062.32
12106.96
12130.01
12153.05
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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0
0
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0
0
0
0
0
0
8833
9497
3590
5276
23412
9161
16390
19810
30651
8449
35813
35773
14003
22914
10037
3532
4452
16298
4435
13957
2523
20141
12758
16172
5451
6344
6887
7262
10632
12776
5246
11119
9270
4530
5436
10306
8022
6600
13655
7145
15325
2151
4631
13.63
14.65
5.54
8.14
36.12
14.14
25.29
30.57
47.29
13.04
55.26
55.2
21.61
35.36
15.49
5.45
6.87
25.15
6.84
21.54
3.89
31.08
19.69
24.95
8.41
9.79
10.63
11.2
16.4
19.71
8.09
17.16
14.3
6.99
8.39
15.9
12.38
10.18
21.07
11.02
23.65
3.32
7.15
8833.02
9497.21
3589.96
5276
23411.87
9161.04
16389.65
19809.88
30650.87
8449.34
35812.82
35772.72
14002.91
22913.82
10037.01
3531.69
4452.01
16298.45
4434.98
13957.1
2523.27
20140.56
12758.14
16172.4
5450.88
6343.63
6886.59
7261.52
10631.94
12775.68
5246.15
11118.81
9270.36
4530.31
5436.28
10305.79
8022.31
6600.3
13654.78
7145.14
15325.43
2151.38
4630.97
12
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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12178.77394
12197.0696
12222.08249
12240.68072
12278.91258
12293.78547
12315.10091
12336.07905
12384.07913
12397.96743
12423.03526
12444.10068
12463.36964
12481.93819
12516.02051
12544.83889
12574.61749
12597.50392
12640.38028
12672.65489
12691.3169
12708.811
12745.20714
12772.94977
12804.84339
12829.19123
12872.68246
12931.21008
12961.00758
12980.1784
13007.33615
13031.55056
13069.99973
13090.93227
13101.54041
13122.43099
13142.80661
13168.00294
13199.50944
13212.41908
13237.51163
13262.55288
13292.19448
12178.77
12197.07
12222.08
12240.68
12278.91
12293.79
12315.1
12336.08
12384.08
12397.97
12423.04
12444.1
12463.37
12481.94
12516.02
12544.84
12574.62
12597.5
12640.38
12672.65
12691.32
12708.81
12745.21
12772.95
12804.84
12829.19
12872.68
12931.21
12961.01
12980.18
13007.34
13031.55
13070
13090.93
13101.54
13122.43
13142.81
13168
13199.51
13212.42
13237.51
13262.55
13292.19
12178.77
12197.07
12222.08
12240.68
12278.91
12293.79
12315.1
12336.08
12384.08
12397.97
12423.04
12444.1
12463.37
12481.94
12516.02
12544.84
12574.62
12597.5
12640.38
12672.65
12691.32
12708.81
12745.21
12772.95
12804.84
12829.19
12872.68
12931.21
12961.01
12980.18
13007.34
13031.55
13070
13090.93
13101.54
13122.43
13142.81
13168
13199.51
13212.42
13237.51
13262.55
13292.19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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0
0
0
0
0
7301
9669
3730
11259
7337
1632
20067
8670
8898
3923
4931
1729
25553
7133
3386
5933
8538
28676
5864
4672
9155
1519
13268
16990
9989
11579
14777
16115
3197
6491
16402
26415
12357
7925
6252
10458
2134
7486
6124
10159
15322
8010
4422
11.26
14.92
5.76
17.37
11.32
2.52
30.96
13.38
13.73
6.05
7.61
2.67
39.43
11.01
5.22
9.16
13.17
44.25
9.05
7.21
14.13
2.34
20.47
26.21
15.41
17.87
22.8
24.87
4.93
10.02
25.31
40.76
19.07
12.23
9.65
16.14
3.29
11.55
9.45
15.67
23.64
12.36
6.82
7300.68
9669.2
3730.28
11259.46
7337.49
1632.08
20067.35
8669.7
8898.41
3922.98
4931.46
1728.74
25552.58
7132.86
3385.82
5933.47
8537.7
28676.37
5863.92
4672.39
9154.67
1518.95
13268.1
16989.71
9989.29
11579.28
14777.37
16115.02
3196.96
6491.17
16402.43
26414.53
12357.02
7924.62
6251.82
10458.43
2133.58
7486.34
6123.79
10158.55
15321.83
8009.99
4421.66
13
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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13308.55929
13340.19553
13369.35926
13404.23162
13429.23745
13445.40743
13468.8257
13498.61492
13526.25507
13550.51939
13587.69616
13610.89422
13628.71542
13688.70691
13701.59126
13732.57938
13753.34934
13775.96795
13796.39433
13817.85317
13847.01984
13875.21887
13896.7679
13925.52931
13943.07448
13991.57026
14005.50446
14036.50207
14090.64435
14139.57749
14169.57756
14202.64879
14227.17806
14250.46773
14266.02515
14283.36974
14303.20768
14333.15463
14350.44258
14367.08638
14392.52375
14439.68476
14451.22637
13308.56
13340.2
13369.36
13404.23
13429.24
13445.41
13468.83
13498.61
13526.26
13550.52
13587.7
13610.89
13628.72
13688.71
13701.59
13732.58
13753.35
13775.97
13796.39
13817.85
13847.02
13875.22
13896.77
13925.53
13943.07
13991.57
14005.5
14036.5
14090.64
14139.58
14169.58
14202.65
14227.18
14250.47
14266.03
14283.37
14303.21
14333.15
14350.44
14367.09
14392.52
14439.68
14451.23
13308.56
13340.2
13369.36
13404.23
13429.24
13445.41
13468.83
13498.61
13526.26
13550.52
13587.7
13610.89
13628.72
13688.71
13701.59
13732.58
13753.35
13775.97
13796.39
13817.85
13847.02
13875.22
13896.77
13925.53
13943.07
13991.57
14005.5
14036.5
14090.64
14139.58
14169.58
14202.65
14227.18
14250.47
14266.03
14283.37
14303.21
14333.15
14350.44
14367.09
14392.52
14439.68
14451.23
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
6686
2696
7607
9036
5452
1680
12925
2079
6860
13925
23370
3903
22766
2147
9485
4418
7876
3272
10578
4153
8197
15493
5624
2966
7432
2931
3280
3647
14319
1919
11236
6393
1881
3253
3457
3971
6193
1306
4852
9369
13701
3075
7095
10.32
4.16
11.74
13.94
8.41
2.59
19.94
3.21
10.58
21.49
36.06
6.02
35.13
3.31
14.64
6.82
12.15
5.05
16.32
6.41
12.65
23.91
8.68
4.58
11.47
4.52
5.06
5.63
22.09
2.96
17.34
9.86
2.9
5.02
5.33
6.13
9.56
2.01
7.49
14.46
21.14
4.74
10.95
6685.7
2696.34
7607.13
9035.62
5452.42
1680.34
12925.28
2079.29
6859.95
13925.17
23370.43
3903.44
22765.74
2146.69
9484.91
4418.24
7876.01
3271.66
10578.2
4152.51
8196.67
15493.03
5623.74
2965.64
7432.22
2931.43
3279.51
3647.17
14319.44
1919.39
11235.95
6393.07
1881.06
3252.61
3457.43
3970.96
6193.29
1305.89
4851.79
9369.38
13701.19
3075.04
7094.67
14
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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333
14486.82011
14518.01346
14582.55647
14603.15386
14632.25684
14692.62535
14740.61138
14779.06885
14851.058
14885.77307
14923.9019
14953.57643
15021.4995
15039.18187
15088.74671
15119.73222
15164.86325
15212.40584
15247.46305
15291.02257
15312.23079
15342.32151
15413.05612
15447.23223
15467.72271
15485.22362
15508.71573
15551.26875
15585.96905
15631.78528
15683.2234
15721.2878
15764.47019
15812.21213
15854.59869
15877.19117
15905.97067
15924.51209
15966.23506
16027.39008
16078.64209
16110.13995
16146.87735
14486.82
14518.01
14582.56
14603.15
14632.26
14692.63
14740.61
14779.07
14851.06
14885.77
14923.9
14953.58
15021.5
15039.18
15088.75
15119.73
15164.86
15212.41
15247.46
15291.02
15312.23
15342.32
15413.06
15447.23
15467.72
15485.22
15508.72
15551.27
15585.97
15631.79
15683.22
15721.29
15764.47
15812.21
15854.6
15877.19
15905.97
15924.51
15966.24
16027.39
16078.64
16110.14
16146.88
14486.82
14518.01
14582.56
14603.15
14632.26
14692.63
14740.61
14779.07
14851.06
14885.77
14923.9
14953.58
15021.5
15039.18
15088.75
15119.73
15164.86
15212.41
15247.46
15291.02
15312.23
15342.32
15413.06
15447.23
15467.72
15485.22
15508.72
15551.27
15585.97
15631.79
15683.22
15721.29
15764.47
15812.21
15854.6
15877.19
15905.97
15924.51
15966.24
16027.39
16078.64
16110.14
16146.88
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
5178
12166
11514
5802
8806
18630
13282
9839
12110
9242
10603
3703
4184
7297
9020
17628
13476
2747
11700
2760
4738
2561
10110
3837
6208
4388
8030
1318
8069
11419
14283
8135
3682
5397
4379
1556
2765
2231
5129
19502
5508
11913
2222
7.99
18.77
17.77
8.95
13.59
28.75
20.49
15.18
18.69
14.26
16.36
5.71
6.46
11.26
13.92
27.2
20.79
4.24
18.05
4.26
7.31
3.95
15.6
5.92
9.58
6.77
12.39
2.03
12.45
17.62
22.04
12.55
5.68
8.33
6.76
2.4
4.27
3.44
7.91
30.09
8.5
18.38
3.43
5177.81
12165.76
11513.77
5801.5
8806
18629.75
13282.18
9839.44
12110.31
9241.53
10602.91
3702.88
4183.94
7296.8
9019.6
17627.76
13475.52
2746.5
11700.04
2760.35
4737.89
2561.05
10109.58
3836.84
6208.28
4388.33
8030.07
1318.5
8069.37
11418.67
14283.21
8135.08
3681.76
5396.97
4378.5
1556.16
2764.9
2231.17
5129.24
19502.44
5508.29
11912.62
2221.56
15
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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376
16173.08012
16187.48284
16207.11346
16234.91885
16273.84455
16326.59228
16348.30879
16373.6685
16399.48529
16452.6305
16483.57856
16529.98484
16563.08858
16605.82206
16633.62736
16657.45221
16684.10001
16734.39107
16773.43602
16828.31733
16926.99753
16952.66531
16974.1629
17010.27114
17035.75525
17064.14809
17108.80374
17144.91866
17189.93794
17236.38008
17277.38694
17313.41401
17344.24066
17356.56782
17401.40189
17473.92352
17498.20649
17530.24175
17590.92143
17627.65462
17663.34113
17704.19698
17758.68046
16173.08
16187.48
16207.11
16234.92
16273.84
16326.59
16348.31
16373.67
16399.49
16452.63
16483.58
16529.98
16563.09
16605.82
16633.63
16657.45
16684.1
16734.39
16773.44
16828.32
16927
16952.67
16974.16
17010.27
17035.76
17064.15
17108.8
17144.92
17189.94
17236.38
17277.39
17313.41
17344.24
17356.57
17401.4
17473.92
17498.21
17530.24
17590.92
17627.65
17663.34
17704.2
17758.68
16173.08
16187.48
16207.11
16234.92
16273.84
16326.59
16348.31
16373.67
16399.49
16452.63
16483.58
16529.98
16563.09
16605.82
16633.63
16657.45
16684.1
16734.39
16773.44
16828.32
16927
16952.67
16974.16
17010.27
17035.76
17064.15
17108.8
17144.92
17189.94
17236.38
17277.39
17313.41
17344.24
17356.57
17401.4
17473.92
17498.21
17530.24
17590.92
17627.65
17663.34
17704.2
17758.68
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
4693
2557
7296
8716
4419
7047
2134
2025
8838
9500
5122
7375
7247
5926
3509
6529
5812
17151
4173
6051
5693
4427
8109
4103
1415
7439
4708
2101
3735
3795
11517
2689
4397
7539
6260
4308
7501
12543
3977
2888
7761
2561
10430
7.24
3.94
11.26
13.45
6.82
10.87
3.29
3.12
13.64
14.66
7.9
11.38
11.18
9.14
5.41
10.07
8.97
26.46
6.44
9.34
8.78
6.83
12.51
6.33
2.18
11.48
7.26
3.24
5.76
5.86
17.77
4.15
6.78
11.63
9.66
6.65
11.57
19.35
6.14
4.46
11.98
3.95
16.09
4692.96
2556.59
7296.48
8716.2
4419.34
7047.22
2134.17
2025.1
8838.46
9499.84
5121.97
7375.35
7246.86
5925.89
3509
6529.2
5811.69
17151.07
4172.82
6051.44
5693.35
4427.19
8109.23
4103.16
1414.78
7438.83
4707.69
2101.29
3734.78
3795.31
11516.76
2688.73
4397.21
7538.94
6259.89
4307.86
7501.01
12543.18
3977.32
2887.75
7761.15
2561.38
10430.48
16
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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419
17804.0661
17854.42215
17907.80284
17993.53385
18026.12786
18061.87547
18079.59715
18106.01522
18139.32452
18176.20819
18242.54937
18266.51414
18351.78743
18403.25478
18449.56319
18482.94149
18587.95184
18645.08472
18655.90975
18696.29871
18745.07463
18790.90623
18808.72301
18834.38178
18908.21628
18963.02404
19013.5108
19093.76575
19168.62933
19250.92069
19290.15419
19327.31534
19346.52483
19400.30029
19440.18941
19460.38196
19487.68786
19539.75905
19583.69497
19629.69382
19652.2631
19702.8883
19726.25085
17804.07
17854.42
17907.8
17993.53
18026.13
18061.88
18079.6
18106.02
18139.32
18176.21
18242.55
18266.51
18351.79
18403.25
18449.56
18482.94
18587.95
18645.08
18655.91
18696.3
18745.07
18790.91
18808.72
18834.38
18908.22
18963.02
19013.51
19093.77
19168.63
19250.92
19290.15
19327.32
19346.52
19400.3
19440.19
19460.38
19487.69
19539.76
19583.69
19629.69
19652.26
19702.89
19726.25
17804.07
17854.42
17907.8
17993.53
18026.13
18061.88
18079.6
18106.02
18139.32
18176.21
18242.55
18266.51
18351.79
18403.25
18449.56
18482.94
18587.95
18645.08
18655.91
18696.3
18745.07
18790.91
18808.72
18834.38
18908.22
18963.02
19013.51
19093.77
19168.63
19250.92
19290.15
19327.32
19346.52
19400.3
19440.19
19460.38
19487.69
19539.76
19583.69
19629.69
19652.26
19702.89
19726.25
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7842
11927
4075
5456
4499
5610
4153
6511
1316
4119
4778
4589
9964
6748
3857
7355
6549
7662
6626
10870
9228
3285
1966
7533
6301
10097
23507
7255
18626
5801
8344
8349
8352
12602
1510
4093
9183
8255
5420
2723
4368
2706
3864
12.1
18.4
6.29
8.42
6.94
8.66
6.41
10.05
2.03
6.36
7.37
7.08
15.37
10.41
5.95
11.35
10.1
11.82
10.22
16.77
14.24
5.07
3.03
11.62
9.72
15.58
36.27
11.19
28.74
8.95
12.87
12.88
12.89
19.44
2.33
6.32
14.17
12.74
8.36
4.2
6.74
4.17
5.96
7842.18
11926.79
4074.51
5455.95
4499.03
5610.35
4153.46
6510.84
1315.77
4118.65
4777.98
4588.95
9963.9
6747.94
3856.62
7354.68
6548.72
7662.41
6625.98
10869.8
9227.51
3285.5
1966.07
7532.54
6301.25
10096.94
23507.39
7254.84
18625.53
5801.08
8343.75
8348.55
8351.67
12601.95
1510.35
4093.21
9183.05
8255.22
5420.43
2723.21
4367.97
2705.76
3863.59
17
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
19771.01707
19823.92619
19877.32035
19896.82482
19939.58903
19985.37695
20119.02791
20164.2317
20266.86039
20314.04876
20389.65854
20440.9929
20463.85606
20515.51568
20542.99405
20714.31699
20773.22575
20816.36557
20872.93593
20909.69815
20948.61439
21003.14848
21057.67804
21190.39613
21279.14337
21354.17312
21397.45633
21464.67206
21547.95517
21618.59991
21693.50359
21822.55902
21858.41175
21949.84596
22013.24546
22064.71398
22134.51337
22173.2166
22248.46904
22278.24426
22391.17713
22441.08478
22517.38789
19771.02
19823.93
19877.32
19896.82
19939.59
19985.38
20119.03
20164.23
20266.86
20314.05
20389.66
20440.99
20463.86
20515.52
20542.99
20714.32
20773.23
20816.37
20872.94
20909.7
20948.61
21003.15
21057.68
21190.4
21279.14
21354.17
21397.46
21464.67
21547.96
21618.6
21693.5
21822.56
21858.41
21949.85
22013.25
22064.71
22134.51
22173.22
22248.47
22278.24
22391.18
22441.08
22517.39
19771.02
19823.93
19877.32
19896.82
19939.59
19985.38
20119.03
20164.23
20266.86
20314.05
20389.66
20440.99
20463.86
20515.52
20542.99
20714.32
20773.23
20816.37
20872.94
20909.7
20948.61
21003.15
21057.68
21190.4
21279.14
21354.17
21397.46
21464.67
21547.96
21618.6
21693.5
21822.56
21858.41
21949.85
22013.25
22064.71
22134.51
22173.22
22248.47
22278.24
22391.18
22441.08
22517.39
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3592
1589
1766
3088
9114
5858
5268
4702
13255
13778
10078
3482
5661
5806
3639
2820
3905
4141
8299
3111
1831
6594
5380
13657
2099
1460
2475
7149
20722
12516
1981
1911
2420
16913
4886
5857
9410
6996
4195
1310
2041
6977
5290
5.54
2.45
2.72
4.76
14.06
9.04
8.13
7.25
20.45
21.26
15.55
5.37
8.74
8.96
5.62
4.35
6.03
6.39
12.81
4.8
2.83
10.17
8.3
21.07
3.24
2.25
3.82
11.03
31.97
19.31
3.06
2.95
3.73
26.1
7.54
9.04
14.52
10.79
6.47
2.02
3.15
10.76
8.16
3591.96
1589.21
1765.76
3088.07
9113.53
5858.39
5268.44
4701.73
13255.02
13778.14
10077.87
3482.11
5661.42
5805.56
3639.44
2819.71
3905.21
4141.12
8299.08
3110.54
1831.32
6593.99
5379.98
13657.09
2098.75
1459.7
2475.06
7148.88
20722.49
12515.99
1980.76
1910.85
2419.67
16912.63
4886.06
5857.09
9410.15
6996.15
4195.44
1310.02
2041.45
6976.55
5290.18
18
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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477
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485
486
487
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489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
22551.91348
22590.46118
22650.03762
22691.8517
22740.34407
22757.55806
22801.08495
22907.70677
22943.20806
23003.56481
23051.30522
23112.50389
23152.72484
23291.28949
23371.51856
23407.84262
23453.85972
23545.20751
23608.74814
23662.56567
23756.07338
23791.97282
23829.21055
23866.02315
23942.62448
23999.71884
24026.52065
24097.65594
24133.13531
24161.75999
24205.12292
24241.95967
24289.78041
24340.82357
24380.34861
24424.43216
24499.43995
24561.23215
24610.78375
24642.13591
24764.20374
24817.57395
24929.80547
22551.91
22590.46
22650.04
22691.85
22740.34
22757.56
22801.08
22907.71
22943.21
23003.56
23051.31
23112.5
23152.72
23291.29
23371.52
23407.84
23453.86
23545.21
23608.75
23662.57
23756.07
23791.97
23829.21
23866.02
23942.62
23999.72
24026.52
24097.66
24133.14
24161.76
24205.12
24241.96
24289.78
24340.82
24380.35
24424.43
24499.44
24561.23
24610.78
24642.14
24764.2
24817.57
24929.81
22551.91
22590.46
22650.04
22691.85
22740.34
22757.56
22801.08
22907.71
22943.21
23003.56
23051.31
23112.5
23152.72
23291.29
23371.52
23407.84
23453.86
23545.21
23608.75
23662.57
23756.07
23791.97
23829.21
23866.02
23942.62
23999.72
24026.52
24097.66
24133.14
24161.76
24205.12
24241.96
24289.78
24340.82
24380.35
24424.43
24499.44
24561.23
24610.78
24642.14
24764.2
24817.57
24929.81
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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0
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2903
5637
9453
13166
6643
9629
2433
5883
5158
1785
2255
1826
2106
4697
3757
5583
2784
8035
6982
6316
3942
4852
2263
3335
1939
2217
1533
2528
1485
8365
2409
4629
10462
8028
5905
2115
2811
5005
3804
16095
1563
6662
12067
4.48
8.7
14.59
20.31
10.25
14.86
3.75
9.08
7.96
2.75
3.48
2.82
3.25
7.25
5.8
8.61
4.3
12.4
10.77
9.75
6.08
7.49
3.49
5.15
2.99
3.42
2.37
3.9
2.29
12.91
3.72
7.14
16.14
12.39
9.11
3.26
4.34
7.72
5.87
24.83
2.41
10.28
18.62
2902.68
5636.56
9453.08
13165.52
6642.92
9629.15
2433.12
5883.46
5158.37
1785.23
2254.76
1826.27
2105.81
4696.76
3756.71
5582.63
2784.43
8034.63
6982.32
6316.27
3941.59
4852.35
2262.77
3334.85
1939.07
2217.49
1533.29
2528.39
1484.71
8365.22
2409.01
4628.7
10462.32
8027.6
5904.75
2114.97
2810.7
5005.08
3803.84
16094.69
1563.06
6662.14
12067.49
19
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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518
519
520
521
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525
526
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528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
25031.4669
25086.03146
25126.60693
25195.10362
25295.86598
25355.07863
25425.44611
25480.84931
25541.08335
25563.33055
25592.90066
25635.42654
25726.19204
25763.63461
25803.02635
25895.74892
25937.52504
25982.88387
26070.90444
26146.27033
26236.23739
26284.99017
26330.61308
26356.20644
26446.83547
26514.78258
26593.22725
26614.56287
26637.97728
26700.42713
26783.38119
26925.87362
26984.3891
27049.19791
27178.325
27267.7004
27355.34163
27428.89417
27571.2736
27626.81779
27714.48141
27775.92435
27818.62516
25031.47
25086.03
25126.61
25195.1
25295.87
25355.08
25425.45
25480.85
25541.08
25563.33
25592.9
25635.43
25726.19
25763.63
25803.03
25895.75
25937.53
25982.88
26070.9
26146.27
26236.24
26284.99
26330.61
26356.21
26446.84
26514.78
26593.23
26614.56
26637.98
26700.43
26783.38
26925.87
26984.39
27049.2
27178.32
27267.7
27355.34
27428.89
27571.27
27626.82
27714.48
27775.92
27818.63
25031.47
25086.03
25126.61
25195.1
25295.87
25355.08
25425.45
25480.85
25541.08
25563.33
25592.9
25635.43
25726.19
25763.63
25803.03
25895.75
25937.53
25982.88
26070.9
26146.27
26236.24
26284.99
26330.61
26356.21
26446.84
26514.78
26593.23
26614.56
26637.98
26700.43
26783.38
26925.87
26984.39
27049.2
27178.32
27267.7
27355.34
27428.89
27571.27
27626.82
27714.48
27775.92
27818.63
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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0
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0
0
0
0
1846
4420
3219
6822
8757
3639
2725
8914
6323
5032
2704
1795
3745
6090
10591
4372
3896
5618
8771
14572
3762
2811
6576
1889
2216
2453
1624
1634
3074
4754
9310
10902
6554
2465
5341
2959
1801
4500
1421
8003
10733
5430
2867
2.85
6.82
4.97
10.53
13.51
5.61
4.2
13.75
9.76
7.76
4.17
2.77
5.78
9.4
16.34
6.75
6.01
8.67
13.53
22.48
5.81
4.34
10.15
2.91
3.42
3.78
2.51
2.52
4.74
7.34
14.37
16.82
10.11
3.8
8.24
4.57
2.78
6.94
2.19
12.35
16.56
8.38
4.42
1846.33
4419.67
3219.23
6822.19
8756.78
3638.52
2724.83
8913.65
6323.14
5032.32
2704.09
1794.59
3745.12
6090.05
10590.75
4372.18
3896.29
5618.26
8771.44
14571.73
3762.49
2810.85
6576.21
1888.63
2215.63
2452.89
1624.24
1634.45
3073.71
4754.14
9309.99
10902.29
6553.92
2464.87
5340.91
2958.83
1801.17
4500.07
1421.45
8002.86
10732.9
5429.97
2866.75
20
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
549
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551
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555
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557
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559
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563
564
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579
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581
582
583
584
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586
587
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589
590
591
27861.05649
27956.81379
28008.1579
28128.01869
28201.24689
28258.51642
28302.94237
28421.75163
28507.36111
28595.32925
28670.56048
28738.19225
28920.24827
29063.84993
29114.44798
29142.2189
29201.80191
29242.56173
29342.38615
29396.36982
29445.97801
29525.25288
29564.20877
29754.87248
29821.06824
29872.44101
29912.31254
29955.80609
30013.74777
30051.31483
30080.7517
30164.90623
30271.67163
30310.92822
30513.46524
30551.27696
30705.32005
30886.87384
31013.31856
31068.12606
31158.98293
31249.36289
31307.73948
27861.06
27956.81
28008.16
28128.02
28201.25
28258.52
28302.94
28421.75
28507.36
28595.33
28670.56
28738.19
28920.25
29063.85
29114.45
29142.22
29201.8
29242.56
29342.39
29396.37
29445.98
29525.25
29564.21
29754.87
29821.07
29872.44
29912.31
29955.81
30013.75
30051.31
30080.75
30164.91
30271.67
30310.93
30513.47
30551.28
30705.32
30886.87
31013.32
31068.13
31158.98
31249.36
31307.74
27861.06
27956.81
28008.16
28128.02
28201.25
28258.52
28302.94
28421.75
28507.36
28595.33
28670.56
28738.19
28920.25
29063.85
29114.45
29142.22
29201.8
29242.56
29342.39
29396.37
29445.98
29525.25
29564.21
29754.87
29821.07
29872.44
29912.31
29955.81
30013.75
30051.31
30080.75
30164.91
30271.67
30310.93
30513.47
30551.28
30705.32
30886.87
31013.32
31068.13
31158.98
31249.36
31307.74
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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0
0
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0
0
0
0
0
0
0
1889
9846
1959
4873
3291
3943
3292
6054
3333
5519
5645
2338
5247
5360
1619
1382
4093
5149
1890
4283
6019
6191
2269
7990
3553
7268
2794
5224
3333
2326
2375
4488
3564
4369
2981
4664
9299
6566
2798
2700
9286
3192
2434
2.91
15.19
3.02
7.52
5.08
6.08
5.08
9.34
5.14
8.52
8.71
3.61
8.1
8.27
2.5
2.13
6.32
7.94
2.92
6.61
9.29
9.55
3.5
12.33
5.48
11.21
4.31
8.06
5.14
3.59
3.66
6.93
5.5
6.74
4.6
7.2
14.35
10.13
4.32
4.17
14.33
4.92
3.76
1889.15
9846.29
1959.43
4873.09
3291.41
3943.39
3292.36
6054.38
3332.65
5519.48
5645.06
2338.17
5247.16
5360.05
1619.33
1382.41
4093.15
5148.84
1890.04
4282.53
6018.53
6191.13
2268.71
7990.34
3553.09
7268.22
2794.12
5224.24
3332.5
2326.23
2374.88
4488.06
3564.49
4369.46
2981.36
4664.23
9299.05
6566.13
2798.07
2700.05
9286.09
3191.81
2433.88
21
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
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619
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621
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623
624
625
626
627
628
629
630
631
632
633
634
31376.77041
31502.30944
31611.64682
31881.0232
31975.47897
32023.92116
32069.92701
32136.02302
32210.9941
32445.44493
32493.69822
33007.61261
33100.0858
33174.80712
33375.28816
33428.82237
33469.37372
33511.31024
33608.33349
33675.7968
33737.4811
33793.19211
33859.0455
33897.34234
33975.1254
34175.35124
34299.78603
34358.32333
34422.18907
34456.70577
34639.11206
34751.38071
34834.45197
34983.60742
35046.67178
35094.35342
35142.75742
35290.80436
35351.18827
35460.59072
35708.49215
35914.55594
35972.99983
31376.77
31502.31
31611.65
31881.02
31975.48
32023.92
32069.93
32136.02
32210.99
32445.44
32493.7
33007.61
33100.09
33174.81
33375.29
33428.82
33469.37
33511.31
33608.33
33675.8
33737.48
33793.19
33859.05
33897.34
33975.13
34175.35
34299.79
34358.32
34422.19
34456.71
34639.11
34751.38
34834.45
34983.61
35046.67
35094.35
35142.76
35290.8
35351.19
35460.59
35708.49
35914.56
35973
31376.77
31502.31
31611.65
31881.02
31975.48
32023.92
32069.93
32136.02
32210.99
32445.44
32493.7
33007.61
33100.09
33174.81
33375.29
33428.82
33469.37
33511.31
33608.33
33675.8
33737.48
33793.19
33859.05
33897.34
33975.13
34175.35
34299.79
34358.32
34422.19
34456.71
34639.11
34751.38
34834.45
34983.61
35046.67
35094.35
35142.76
35290.8
35351.19
35460.59
35708.49
35914.56
35973
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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0
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0
0
0
0
1592
3156
1410
2689
4066
1618
7389
1783
1592
1635
1457
2147
10935
9432
8937
1427
2012
1359
2416
2835
4894
3147
1993
1537
3231
4390
2554
5900
2698
2460
9010
4553
5874
1467
2496
1909
5181
6062
3587
5111
14831
8577
5894
2.46
4.87
2.18
4.15
6.27
2.5
11.4
2.75
2.46
2.52
2.25
3.31
16.87
14.55
13.79
2.2
3.1
2.1
3.73
4.37
7.55
4.86
3.08
2.37
4.99
6.77
3.94
9.1
4.16
3.8
13.9
7.03
9.06
2.26
3.85
2.95
7.99
9.35
5.54
7.89
22.88
13.23
9.09
1591.55
3155.8
1410
2689.26
4066.23
1618.44
7388.77
1782.63
1592.06
1634.96
1456.75
2147.18
10934.86
9432.29
8937.4
1427.37
2012.14
1359.5
2415.99
2834.5
4894.33
3147.24
1993.13
1536.93
3231.32
4390.18
2553.6
5900.3
2698.15
2459.6
9009.84
4553.48
5873.97
1467.26
2495.57
1909.27
5180.54
6062.24
3587.3
5110.81
14830.7
8576.77
5894.28
22
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
635
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677
36042.37377
36140.82609
36206.05385
36320.76758
36464.72184
36642.10152
36681.48541
36769.97813
36926.52166
37037.94299
37080.03141
37232.50747
37296.25979
37375.17496
37435.27686
37522.88338
37644.67772
37829.82572
37858.59383
37975.67727
38095.20547
38197.16801
38254.57181
38341.74101
38389.76921
38690.02268
39067.78354
39149.84695
39194.0269
39337.19351
39436.14578
39531.17694
39702.18774
39759.41904
39836.62159
39876.98401
39909.70242
40510.0649
40559.08437
40614.14025
40706.9323
40799.14666
41003.47782
36042.37
36140.83
36206.05
36320.77
36464.72
36642.1
36681.49
36769.98
36926.52
37037.94
37080.03
37232.51
37296.26
37375.17
37435.28
37522.88
37644.68
37829.83
37858.59
37975.68
38095.21
38197.17
38254.57
38341.74
38389.77
38690.02
39067.78
39149.85
39194.03
39337.19
39436.15
39531.18
39702.19
39759.42
39836.62
39876.98
39909.7
40510.06
40559.08
40614.14
40706.93
40799.15
41003.48
36042.37
36140.83
36206.05
36320.77
36464.72
36642.1
36681.49
36769.98
36926.52
37037.94
37080.03
37232.51
37296.26
37375.17
37435.28
37522.88
37644.68
37829.83
37858.59
37975.68
38095.21
38197.17
38254.57
38341.74
38389.77
38690.02
39067.78
39149.85
39194.03
39337.19
39436.15
39531.18
39702.19
39759.42
39836.62
39876.98
39909.7
40510.06
40559.08
40614.14
40706.93
40799.15
41003.48
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2374
5698
2998
1723
3734
3200
4059
4046
4131
5263
5415
3109
4042
4653
3266
2162
5253
1686
5640
1701
5966
2765
6045
4229
3587
4406
2030
3559
2242
6347
3090
1460
1412
1308
1954
1951
2674
2231
2244
2624
2775
6113
4830
3.66
8.79
4.63
2.66
5.76
4.94
6.26
6.24
6.37
8.12
8.36
4.8
6.24
7.18
5.04
3.34
8.11
2.6
8.7
2.63
9.21
4.27
9.33
6.53
5.54
6.8
3.13
5.49
3.46
9.79
4.77
2.25
2.18
2.02
3.02
3.01
4.13
3.44
3.46
4.05
4.28
9.43
7.45
2374.44
5698.26
2998.28
1723.33
3733.59
3200.41
4058.66
4046.16
4130.53
5262.86
5415.39
3109.43
4041.76
4653.21
3265.58
2161.82
5253.32
1686.2
5640.43
1701.37
5966.06
2765.41
6044.7
4229.4
3587.27
4406.28
2029.95
3559.2
2241.93
6346.53
3089.7
1459.61
1411.99
1307.52
1954.08
1950.64
2674.48
2231.17
2243.55
2623.78
2775.32
6113.07
4829.8
23
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
678
679
680
681
682
683
684
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686
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688
689
690
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693
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701
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705
706
707
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709
710
711
712
713
714
715
716
717
718
719
720
41232.96778
41655.10395
41723.55763
41833.15847
42008.72677
42119.09451
42255.33484
42319.16187
42409.58335
42688.95085
42762.81713
42835.83747
42930.71946
43018.35188
43182.85891
43280.49622
43387.22131
43501.57677
43717.70731
43830.79639
43960.25532
44061.75802
44164.53555
44270.80551
44340.57618
44543.95857
44601.44579
44793.3086
44893.49616
44984.79607
45043.47346
45082.92726
45484.10152
45609.75765
45678.44941
45849.21891
46012.61234
46131.34752
46246.12009
46444.53529
46919.03101
46962.01345
47178.00546
41232.97
41655.1
41723.56
41833.16
42008.73
42119.09
42255.33
42319.16
42409.58
42688.95
42762.82
42835.84
42930.72
43018.35
43182.86
43280.5
43387.22
43501.58
43717.71
43830.8
43960.26
44061.76
44164.54
44270.81
44340.58
44543.96
44601.45
44793.31
44893.5
44984.8
45043.47
45082.93
45484.1
45609.76
45678.45
45849.22
46012.61
46131.35
46246.12
46444.54
46919.03
46962.01
47178.01
41232.97
41655.1
41723.56
41833.16
42008.73
42119.09
42255.33
42319.16
42409.58
42688.95
42762.82
42835.84
42930.72
43018.35
43182.86
43280.5
43387.22
43501.58
43717.71
43830.8
43960.26
44061.76
44164.54
44270.81
44340.58
44543.96
44601.45
44793.31
44893.5
44984.8
45043.47
45082.93
45484.1
45609.76
45678.45
45849.22
46012.61
46131.35
46246.12
46444.54
46919.03
46962.01
47178.01
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1813
3744
3279
1737
1380
1490
2439
2399
1376
5468
6246
2649
3889
3242
6759
3173
2190
1585
4602
4541
5717
4327
3500
2035
2379
3162
1870
9593
4478
4512
1515
1943
2344
2723
1748
1321
5874
2312
2182
2099
2460
3083
2044
2.8
5.78
5.06
2.68
2.13
2.3
3.76
3.7
2.12
8.44
9.64
4.09
6
5
10.43
4.9
3.38
2.45
7.1
7.01
8.82
6.68
5.4
3.14
3.67
4.88
2.88
14.8
6.91
6.96
2.34
3
3.62
4.2
2.7
2.04
9.06
3.57
3.37
3.24
3.8
4.76
3.15
1812.99
3743.64
3279.13
1737.28
1380.5
1489.69
2439.49
2399.21
1376.44
5468.14
6246.1
2649.03
3888.62
3241.87
6758.87
3173.1
2189.82
1584.59
4601.68
4541.07
5716.87
4327.31
3499.53
2034.99
2379.38
3162.41
1869.67
9592.78
4478.22
4512.02
1515.07
1943.1
2343.52
2722.67
1748.46
1321.23
5873.62
2312.47
2181.9
2098.9
2460.13
3082.68
2043.76
24
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
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740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
47451.56111
47671.98838
47749.6663
47807.14871
47890.91333
47941.24827
48005.33276
48111.31771
48241.70913
48403.82858
48473.76057
48773.25501
48920.44627
49062.07495
49385.01424
49558.99394
49756.26213
49973.91614
50281.29527
50395.99211
50967.47004
51092.11709
51158.52182
51282.21412
51412.90117
51516.70114
51830.17984
51941.66576
51998.24379
52423.71642
52481.45377
52551.27447
52619.56169
52781.64693
52972.70642
53078.62571
53445.89677
53678.15797
53900.97965
54168.51812
54347.26544
54497.48678
54591.43596
47451.56
47671.99
47749.67
47807.15
47890.91
47941.25
48005.33
48111.32
48241.71
48403.83
48473.76
48773.26
48920.45
49062.07
49385.01
49558.99
49756.26
49973.92
50281.3
50395.99
50967.47
51092.12
51158.52
51282.21
51412.9
51516.7
51830.18
51941.67
51998.24
52423.72
52481.45
52551.27
52619.56
52781.65
52972.71
53078.63
53445.9
53678.16
53900.98
54168.52
54347.27
54497.49
54591.44
47451.56
47671.99
47749.67
47807.15
47890.91
47941.25
48005.33
48111.32
48241.71
48403.83
48473.76
48773.26
48920.45
49062.07
49385.01
49558.99
49756.26
49973.92
50281.3
50395.99
50967.47
51092.12
51158.52
51282.21
51412.9
51516.7
51830.18
51941.67
51998.24
52423.72
52481.45
52551.27
52619.56
52781.65
52972.71
53078.63
53445.9
53678.16
53900.98
54168.52
54347.27
54497.49
54591.44
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3907
1423
1574
3052
3103
2266
3910
3331
4081
1403
1527
1772
2140
2664
2832
1341
9794
3809
3871
1456
12639
3784
4669
2269
4473
1880
2170
3240
1858
1497
2030
1652
1469
3091
6033
7743
5198
5060
1453
4215
6261
5135
1383
6.03
2.2
2.43
4.71
4.79
3.5
6.03
5.14
6.3
2.17
2.36
2.73
3.3
4.11
4.37
2.07
15.11
5.88
5.97
2.25
19.5
5.84
7.2
3.5
6.9
2.9
3.35
5
2.87
2.31
3.13
2.55
2.27
4.77
9.31
11.95
8.02
7.81
2.24
6.5
9.66
7.92
2.13
3906.65
1423.06
1573.58
3051.7
3103
2265.99
3910.04
3331.47
4080.95
1403.22
1526.86
1771.62
2139.82
2663.63
2832.24
1340.88
9793.95
3809.49
3870.59
1455.61
12639.47
3783.69
4668.55
2268.67
4472.67
1880.46
2170.02
3239.57
1858.21
1497.48
2030.13
1651.63
1469.16
3091.31
6033.24
7743.07
5198.27
5060.4
1452.88
4215.21
6260.61
5134.56
1382.74
25
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
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782
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784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
54659.94021
54835.25796
54978.90794
55793.47439
56041.51953
56123.37365
56208.83622
56270.25218
56570.15692
56728.34318
56794.62227
56870.608
57192.49641
57433.06708
57521.29214
57580.50105
57652.4281
58094.37879
58205.86596
58392.86644
58484.386
59102.21303
59362.90422
59521.83187
59657.81009
59800.50507
59949.00443
60097.73147
60306.21352
60476.98435
61121.03081
61208.27375
61363.27474
61762.28254
61832.00061
61938.19001
62125.9876
62390.87375
62482.12866
62819.68904
63157.64433
63348.9405
63465.45953
54659.94
54835.26
54978.91
55793.47
56041.52
56123.37
56208.84
56270.25
56570.16
56728.34
56794.62
56870.61
57192.5
57433.07
57521.29
57580.5
57652.43
58094.38
58205.87
58392.87
58484.39
59102.21
59362.9
59521.83
59657.81
59800.51
59949
60097.73
60306.21
60476.98
61121.03
61208.27
61363.27
61762.28
61832
61938.19
62125.99
62390.87
62482.13
62819.69
63157.64
63348.94
63465.46
54659.94
54835.26
54978.91
55793.47
56041.52
56123.37
56208.84
56270.25
56570.16
56728.34
56794.62
56870.61
57192.5
57433.07
57521.29
57580.5
57652.43
58094.38
58205.87
58392.87
58484.39
59102.21
59362.9
59521.83
59657.81
59800.51
59949
60097.73
60306.21
60476.98
61121.03
61208.27
61363.27
61762.28
61832
61938.19
62125.99
62390.87
62482.13
62819.69
63157.64
63348.94
63465.46
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2441
3752
2631
4091
1693
1738
2426
4212
1667
1966
1442
1831
1952
5287
3805
3014
1780
3550
3601
3843
2433
1979
1363
2039
2859
3550
2498
5420
1635
1777
5417
2952
2730
2519
1731
2743
3569
2500
2496
1414
4827
5090
5770
3.77
5.79
4.06
6.31
2.61
2.68
3.74
6.5
2.57
3.03
2.23
2.83
3.01
8.16
5.87
4.65
2.75
5.48
5.56
5.93
3.75
3.05
2.1
3.15
4.41
5.48
3.85
8.36
2.52
2.74
8.36
4.55
4.21
3.89
2.67
4.23
5.51
3.86
3.85
2.18
7.45
7.85
8.9
2440.87
3751.56
2630.96
4091.21
1693.22
1737.73
2425.71
4211.76
1666.58
1965.75
1442.08
1830.93
1952.11
5286.66
3805.08
3014.3
1779.9
3550.33
3601.11
3842.58
2433.19
1978.98
1362.53
2039
2859.37
3549.86
2497.94
5419.8
1635.04
1776.56
5417.06
2951.79
2730.19
2518.96
1731.33
2742.53
3568.83
2500.13
2495.58
1413.82
4827.2
5089.65
5769.73
26
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
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827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
63618.57218
63683.07454
64308.42071
64435.76685
64529.10799
64645.741
64747.40754
65007.84687
65535.49225
65675.20315
65783.02988
65837.81529
66384.24306
66545.02746
66632.83092
66755.75405
66865.48561
67311.20735
67619.03043
67853.28343
68015.49426
68235.06356
68339.12024
68498.31135
69204.62282
69269.14803
69400.4874
69492.91266
69929.39744
70222.10609
70523.8375
71792.01668
72457.99029
72707.23263
72810.4406
72966.22091
73275.44302
73473.75172
73583.45823
74035.1818
74283.23887
74454.94352
74721.11929
63618.57
63683.07
64308.42
64435.77
64529.11
64645.74
64747.41
65007.85
65535.49
65675.2
65783.03
65837.82
66384.24
66545.03
66632.83
66755.75
66865.49
67311.21
67619.03
67853.28
68015.49
68235.06
68339.12
68498.31
69204.62
69269.15
69400.49
69492.91
69929.4
70222.11
70523.84
71792.02
72457.99
72707.23
72810.44
72966.22
73275.44
73473.75
73583.46
74035.18
74283.24
74454.94
74721.12
63618.57
63683.07
64308.42
64435.77
64529.11
64645.74
64747.41
65007.85
65535.49
65675.2
65783.03
65837.82
66384.24
66545.03
66632.83
66755.75
66865.49
67311.21
67619.03
67853.28
68015.49
68235.06
68339.12
68498.31
69204.62
69269.15
69400.49
69492.91
69929.4
70222.11
70523.84
71792.02
72457.99
72707.23
72810.44
72966.22
73275.44
73473.75
73583.46
74035.18
74283.24
74454.94
74721.12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
4444
2588
4065
1724
2844
2633
1658
1509
3562
4030
1867
2015
4262
1406
2504
1300
5444
5958
4224
2389
7138
5465
1983
4766
1853
7114
7804
4124
7460
5451
4276
2201
2422
2401
4340
4351
1503
1968
2644
2638
4046
2874
3000
6.86
3.99
6.27
2.66
4.39
4.06
2.56
2.33
5.5
6.22
2.88
3.11
6.58
2.17
3.86
2.01
8.4
9.19
6.52
3.69
11.01
8.43
3.06
7.35
2.86
10.98
12.04
6.36
11.51
8.41
6.6
3.4
3.74
3.71
6.7
6.71
2.32
3.04
4.08
4.07
6.24
4.43
4.63
4444.28
2587.91
4065.04
1723.59
2843.67
2633.39
1658.09
1509.09
3561.56
4029.88
1867.28
2015.16
4262.24
1405.84
2504.23
1300.15
5444.05
5957.7
4224.06
2389.12
7137.63
5464.84
1982.82
4765.68
1853.49
7113.84
7804.08
4124.04
7460.47
5451.02
4275.51
2201.36
2422.25
2401.24
4339.94
4351.28
1502.99
1968.18
2644.17
2637.82
4046.41
2873.64
3000.16
27
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
850
851
852
853
854
855
856
857
858
859
860
861
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863
864
865
866
867
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871
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879
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885
886
887
888
889
890
891
892
74849.8156
75025.54993
75106.95684
75148.0919
76038.72114
76178.39876
76468.16234
76738.71238
76950.85487
77599.41911
78321.7697
79142.25898
79575.8237
79949.64691
81182.96853
81287.77023
81463.68709
81568.37468
82591.20039
82878.25295
83103.06701
83289.10812
83444.3822
83764.96681
84244.83881
85044.61264
85440.86963
85602.32305
85761.11307
85874.29718
86126.0953
86466.16713
87408.01648
87586.29232
87917.53258
87999.42745
88064.43076
88452.1409
88791.27734
89088.75493
90137.91512
90420.12323
90590.06627
74849.82
75025.55
75106.96
75148.09
76038.72
76178.4
76468.16
76738.71
76950.85
77599.42
78321.77
79142.26
79575.82
79949.65
81182.97
81287.77
81463.69
81568.37
82591.2
82878.25
83103.07
83289.11
83444.38
83764.97
84244.84
85044.61
85440.87
85602.32
85761.11
85874.3
86126.1
86466.17
87408.02
87586.29
87917.53
87999.43
88064.43
88452.14
88791.28
89088.75
90137.92
90420.12
90590.07
74849.82
75025.55
75106.96
75148.09
76038.72
76178.4
76468.16
76738.71
76950.85
77599.42
78321.77
79142.26
79575.82
79949.65
81182.97
81287.77
81463.69
81568.37
82591.2
82878.25
83103.07
83289.11
83444.38
83764.97
84244.84
85044.61
85440.87
85602.32
85761.11
85874.3
86126.1
86466.17
87408.02
87586.29
87917.53
87999.43
88064.43
88452.14
88791.28
89088.75
90137.92
90420.12
90590.07
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2750
2613
2715
1689
1528
4274
7260
2692
1831
1546
4463
1385
1927
2382
1703
1944
1808
1631
2669
1765
1644
1792
5580
2588
1846
3371
2250
3656
3651
2577
1716
1552
1363
2770
2275
1542
1792
4539
3574
2440
4071
3672
2418
4.24
4.03
4.19
2.61
2.36
6.59
11.2
4.15
2.83
2.39
6.89
2.14
2.97
3.68
2.63
3
2.79
2.52
4.12
2.72
2.54
2.76
8.61
3.99
2.85
5.2
3.47
5.64
5.63
3.98
2.65
2.39
2.1
4.27
3.51
2.38
2.77
7
5.52
3.77
6.28
5.67
3.73
2749.91
2612.74
2714.59
1688.65
1528.37
4273.72
7259.78
2691.68
1831.41
1546.4
4462.57
1385.1
1927.31
2382.1
1702.72
1944.44
1807.77
1630.65
2668.82
1765.43
1643.82
1791.58
5580.24
2588.46
1845.89
3371.47
2249.68
3656.38
3650.54
2577.17
1716.11
1551.9
1363.35
2770.37
2275.27
1542.36
1792.07
4538.51
3574.28
2440.15
4070.51
3671.98
2418.26
28
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
91145.21031
91297.90072
91585.59417
92286.32007
92878.52177
93055.74872
93207.0997
93406.03164
93646.70281
94244.13615
94495.34991
95122.7597
95424.44269
95594.21604
95816.35819
96609.58053
97223.78409
97468.31429
97681.16997
97902.54238
98030.92996
98416.60581
98626.52081
98792.64708
98859.20509
99152.7477
99359.00965
99463.42371
99774.5923
99931.407
91145.21
91297.9
91585.59
92286.32
92878.52
93055.75
93207.1
93406.03
93646.7
94244.14
94495.35
95122.76
95424.44
95594.22
95816.36
96609.58
97223.78
97468.31
97681.17
97902.54
98030.93
98416.61
98626.52
98792.65
98859.21
99152.75
99359.01
99463.42
99774.59
99931.41
91145.21
91297.9
91585.59
92286.32
92878.52
93055.75
93207.1
93406.03
93646.7
94244.14
94495.35
95122.76
95424.44
95594.22
95816.36
96609.58
97223.78
97468.31
97681.17
97902.54
98030.93
98416.61
98626.52
98792.65
98859.21
99152.75
99359.01
99463.42
99774.59
99931.41
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2989
3355
5808
1688
1875
1325
1426
1792
2906
4799
2792
7186
2662
1585
3060
4206
24898
3155
1326
2058
2698
2195
4984
2012
3521
2012
2240
2423
1920
2058
4.61
5.18
8.96
2.6
2.89
2.04
2.2
2.77
4.48
7.41
4.31
11.09
4.11
2.45
4.72
6.49
38.42
4.87
2.05
3.17
4.16
3.39
7.69
3.1
5.43
3.1
3.46
3.74
2.96
3.17
2989.21
3354.51
5808.08
1687.98
1874.57
1325.16
1425.99
1792.42
2906.3
4799.23
2791.68
7186.03
2661.64
1584.96
3060.23
4205.57
24898.06
3154.96
1326
2057.58
2697.72
2194.75
4983.92
2011.86
3520.75
2011.86
2240.48
2423.37
1920.41
2057.58
Index
Centroid
Mass
Lower
Bound
Upper
Bound
Charge
(z)
Height
Relative
intensity
Area
1
2
3
4
5
525.63906
530.88114
532.57291
534.81387
537.76009
525.64
530.88
532.57
534.81
537.76
525.64
530.88
532.57
534.81
537.76
0
0
0
0
0
7320
9980
8055
8280
13947
2.25
3.07
2.47
2.54
4.28
7320.39
9980.14
8055.4
8279.82
13947.32
29
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
539.71697
542.89528
543.74455
544.95373
547.66619
548.8223
550.9401
551.65639
552.00071
552.83419
554.3509
558.84676
559.78257
561.63873
562.68592
563.75125
565.78262
566.58949
569.6768
571.56219
573.45516
574.77953
576.94726
580.70903
581.92034
584.54447
587.05032
588.14221
588.86656
591.74872
592.59573
597.78782
599.93287
602.88555
604.84526
610.66984
611.90955
613.74049
619.90039
622.55384
624.87267
625.93732
630.87007
539.72
542.9
543.74
544.95
547.67
548.82
550.94
551.66
552
552.83
554.35
558.85
559.78
561.64
562.69
563.75
565.78
566.59
569.68
571.56
573.46
574.78
576.95
580.71
581.92
584.54
587.05
588.14
588.87
591.75
592.6
597.79
599.93
602.89
604.85
610.67
611.91
613.74
619.9
622.55
624.87
625.94
630.87
539.72
542.9
543.74
544.95
547.67
548.82
550.94
551.66
552
552.83
554.35
558.85
559.78
561.64
562.69
563.75
565.78
566.59
569.68
571.56
573.46
574.78
576.95
580.71
581.92
584.54
587.05
588.14
588.87
591.75
592.6
597.79
599.93
602.89
604.85
610.67
611.91
613.74
619.9
622.55
624.87
625.94
630.87
0
0
0
0
1
1
1
0
1
0
0
1
1
1
1
1
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
1
1
0
8757
11137
8340
10226
19319
8897
8547
7710
7116
10843
14567
12851
9727
19382
22673
7835
7150
13191
35661
19639
7575
11808
17665
16465
21328
7066
8054
6704
7448
14493
10314
11192
8493
7089
7404
10346
15136
25351
7756
17890
10073
6864
7025
2.69
3.42
2.56
3.14
5.93
2.73
2.63
2.37
2.19
3.33
4.47
3.95
2.99
5.95
6.96
2.41
2.2
4.05
10.95
6.03
2.33
3.63
5.43
5.06
6.55
2.17
2.47
2.06
2.29
4.45
3.17
3.44
2.61
2.18
2.27
3.18
4.65
7.79
2.38
5.49
3.09
2.11
2.16
8757.08
11137.08
8339.97
10225.69
19318.53
8896.57
8547.12
7710.37
7115.6
10843.21
14567.06
12851.13
9727.19
19382.24
22672.8
7835.48
7149.9
13190.67
35661.34
19638.53
7575.33
11807.76
17664.68
16465.03
21328.47
7065.98
8053.72
6703.99
7448.39
14492.88
10314.36
11192.4
8492.96
7089.16
7404.42
10346.1
15136.01
25351.35
7755.52
17890.45
10073.27
6864.42
7024.91
30
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
633.78435
643.95509
645.33796
646.81164
649.97874
651.67735
653.50552
654.09033
656.91784
657.59333
658.54209
660.93141
664.64014
667.84091
670.93919
672.49318
673.85236
675.85254
676.70389
677.76877
678.82085
684.8594
686.14007
689.75358
699.68648
700.92858
708.86951
726.75154
729.01643
731.90104
733.98172
743.67292
746.62722
749.2144
760.93497
778.58799
780.11427
783.07656
786.17914
791.83369
793.65317
799.81981
803.95668
633.78
643.96
645.34
646.81
649.98
651.68
653.51
654.09
656.92
657.59
658.54
660.93
664.64
667.84
670.94
672.49
673.85
675.85
676.7
677.77
678.82
684.86
686.14
689.75
699.69
700.93
708.87
726.75
729.02
731.9
733.98
743.67
746.63
749.21
760.93
778.59
780.11
783.08
786.18
791.83
793.65
799.82
803.96
633.78
643.96
645.34
646.81
649.98
651.68
653.51
654.09
656.92
657.59
658.54
660.93
664.64
667.84
670.94
672.49
673.85
675.85
676.7
677.77
678.82
684.86
686.14
689.75
699.69
700.93
708.87
726.75
729.02
731.9
733.98
743.67
746.63
749.21
760.93
778.59
780.11
783.08
786.18
791.83
793.65
799.82
803.96
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
1
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
11907
12215
7923
8140
10764
325602
19447
20988
7835
127244
16075
16880
7639
70780
7780
8608
40951
12172
8615
12703
15936
14365
11579
16208
9363
7432
10893
6812
19828
12904
7656
8612
8126
9949
6622
7431
8757
11437
7548
7641
7355
6914
8626
3.66
3.75
2.43
2.5
3.31
100
5.97
6.45
2.41
39.08
4.94
5.18
2.35
21.74
2.39
2.64
12.58
3.74
2.65
3.9
4.89
4.41
3.56
4.98
2.88
2.28
3.35
2.09
6.09
3.96
2.35
2.64
2.5
3.06
2.03
2.28
2.69
3.51
2.32
2.35
2.26
2.12
2.65
11906.7
12215.5
7922.53
8140.45
10764.19
325601.69
19446.86
20988.07
7835.12
127244.15
16074.94
16879.61
7638.71
70780.01
7779.69
8607.76
40950.68
12171.85
8615.31
12703.38
15935.57
14365.24
11578.58
16207.53
9363.09
7431.61
10892.7
6811.5
19828.36
12904.28
7655.74
8611.55
8125.83
9949.26
6621.89
7430.96
8757.25
11436.62
7548.08
7640.68
7355.38
6913.6
8625.52
31
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
818.95419
855.3258
856.9775
862.71885
864.55013
866.50313
868.4639
878.04006
878.87642
883.61808
885.49115
887.51882
891.11193
898.99899
914.88621
924.43488
934.23027
942.03926
944.74341
946.6284
953.14296
957.25759
960.04869
979.33159
980.22612
999.87652
1011.91622
1024.42436
1048.34962
1065.83554
1067.90023
1073.76855
1074.71465
1079.61203
1091.33902
1093.75608
1103.08826
1223.4262
1224.25865
1267.49881
1268.3317
1275.19299
1284.22659
818.95
855.33
856.98
862.72
864.55
866.5
868.46
878.04
878.88
883.62
885.49
887.52
891.11
899
914.89
924.43
934.23
942.04
944.74
946.63
953.14
957.26
960.05
979.33
980.23
999.88
1011.92
1024.42
1048.35
1065.84
1067.9
1073.77
1074.71
1079.61
1091.34
1093.76
1103.09
1223.43
1224.26
1267.5
1268.33
1275.19
1284.23
818.95
855.33
856.98
862.72
864.55
866.5
868.46
878.04
878.88
883.62
885.49
887.52
891.11
899
914.89
924.43
934.23
942.04
944.74
946.63
953.14
957.26
960.05
979.33
980.23
999.88
1011.92
1024.42
1048.35
1065.84
1067.9
1073.77
1074.71
1079.61
1091.34
1093.76
1103.09
1223.43
1224.26
1267.5
1268.33
1275.19
1284.23
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
6876
7945
32332
223342
59784
11657
13803
7003
19973
9483
10180
7187
8554
8347
8656
6572
6629
7320
8422
8649
8337
105323
10278
26204
7066
9146
8913
8918
18195
10660
12541
22252
31755
15154
6901
9397
7345
9511
7111
8410
13042
8650
10261
2.11
2.44
9.93
68.59
18.36
3.58
4.24
2.15
6.13
2.91
3.13
2.21
2.63
2.56
2.66
2.02
2.04
2.25
2.59
2.66
2.56
32.35
3.16
8.05
2.17
2.81
2.74
2.74
5.59
3.27
3.85
6.83
9.75
4.65
2.12
2.89
2.26
2.92
2.18
2.58
4.01
2.66
3.15
6875.91
7945.5
32332.16
223342.02
59783.59
11656.74
13803.33
7002.68
19972.76
9482.8
10180.29
7186.98
8554.2
8347.1
8655.58
6571.64
6628.88
7319.65
8422.15
8648.69
8336.63
105323.37
10277.89
26204.21
7066.34
9146.25
8913.4
8917.65
18194.96
10659.67
12541.48
22251.77
31755.2
15154.22
6901.37
9397.29
7344.77
9511.29
7111.07
8409.53
13042.49
8649.58
10260.69
32
MMP-2 protects the LDLR
Corresponding author: Carlos Fernandez-Patron
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
1311.44418
1319.17387
1349.90553
1355.55102
1364.15229
1399.57519
1400.77101
1443.48131
1487.59763
1531.59773
1534.34639
1575.62672
1576.75029
1620.54363
1663.87705
1671.69195
1690.44042
1694.3402
1708.66937
1712.4299
1752.35717
1821.44139
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17922.12
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33