DIRECT–TO–CONSUMER ADVERTISING FOR PHARMACEUTICALS IN JORDAN FROM A GENDER PERSPECTIVE Hadeel Ashour and Ibrahim Alabbadi Background ABSTRACT Objective: the aim was to investigate to which extent Direct-to-Consumer Advertising (DTCA) for pharmaceuticals is disseminated -if present- in Jordan and to identify gender differences in this regard. Methods: the study was conducted on two samples: the first represents the patients (drug consumers) coming to the Jordan University Hospital and the second represents the physicians working there (the prescribers). Two questionnaires were designed, the first was distributed to (550) male and female patients, and-consequently-based on its results a second questionnaire was designed and distributed to (200) male and female physicians. The response rate was high (513 and 144 respectively). Results: although the Jordanian Drug and Pharmacy Law prohibits promotion of medicines directly to public; either over the counter drugs (OTC) or prescription only drugs (Rx-only), consumers in Jordan were directly exposed to the pharmaceutical advertising through different ways. Both patients and physicians agreed that the most drug class being advertised directly to consumers are vitamins while drugs used to treat mental illness are the least. Unexpectedly, the 10 top drug classes (out of 31 investigated) found to be advertised directly to consumers in Jordan were Rx-only drugs such as antibiotics and diabetes drugs. Although the results revealed that there are no gender differences towards pharmaceutical DTCA (as there are no significant statistical differences; α 0.05( ≥and in the tools used for pharmaceutical DTCA (α0.05( ≥, the results showed a gender gap in most targeted group exposed to pharmaceutical DTCA as approximately 45% agreed that women are more likely to be targeted by DTCA than men, while only 2% believed that men are more likely to be targeted by DTCA than women. Conclusion: it was concluded that the prohibition of pharmaceuticals DTCA did not prevent Jordanians to be exposed to pharmaceuticals DTCA Methodology Two questionnaires were designed for data collection, based on “Consumer’s Reports on the Health Effects of Direct-To-Consumer Advertising” and “Physicians Report on Patient by Encounters Involving Direct-To-Consumer Advertising” by Prof Joel Weissman from Harvard University. The first was distributed to 10% of patients came to the Jordan University Hospital (JUH) from 20-30 Sept 2008 i.e. (550) male and female patients, and-consequentlybased on its results a second questionnaire was designed and distributed to 57% (200) male and female in JUHphysicians available in October 2008 respondents answers were on Likert scale from 1-4 Statistical analysis SPSS package was used for analyses to describe the sample Analysis of Variance – ANOVA to measure the gender variance-if any Cronbach Alpha was used to measure reliability Demographic data including gender, age, education and profession Health status and sources of information when being ill Major questionnaires domains You refer to: clinicians, advertisements in newspapers, internet, TVs, books, radios, brochures & posters, journals and magazines, medical campaigns, or friends when need medical information Effect of DTCA of pharmaceuticals on behavior when being ill Disease areas in this regard and differences between males & females after exposed to such advertisements All forms of pharmaceutical promotional activities are widely distributed worldwide including pharmaceutical company’s medical representatives’ visits to physicians, the distribution of leaflets, free medical samples, gifts as well as educational posters and brochures. This kind of promotion is currently permitted in Jordan if directed to health professionals (physicians, pharmacists and even nurses) and not directed to consumers (patients), and if complied with drug promotion code of ethics set by the Jordan Food and Drug Administration (JFDA). Although the latter instructions were announced 2 years ago, the real practice in Jordan is something else. Although regulations in most countries all over the world (except USA and New Zealand) prohibit Direct -to-Consumer Advertising for pharmaceuticals (DTCA), it was widely disseminated recently through television satellite channels and the internet. Many western Non-Governmental Organizations (NGOs) were actively opponent the DTCA, such as the women's movement in The European Parliament is considering allowing the drug industry to have a much greater role in providing information to patients, with no restriction on the type of media. The importance of this study that it is expected to reveal the extent of consumer exposure in Jordan - a man or woman - of the pharmaceutical advertisements against him directly i.e. DTCA specially using modern technology. The practical importance of the study lies in drawing the attention of NGOs in Jordan's civil society to look at the issue of selling the drug to consumers and methods of promoting medicines ensuring its questionable effectiveness and safety (counterfeit drugs). Objective The aim of this study was to investigate to which extent Direct-to-Consumer Advertising (DTCA) for pharmaceutical is disseminated-if present- in Jordan and to identify gender differences among consumers in this regard. Results Patients’ (consumers) percentage use for different media in Jordan 37% Using internet regularly Watching TV regularly 86% Reading magazines 64.7% Reading newspapers 88.1% Media exposure: DTCA for pharmaceuticals in Jordan Media type Mean SD Brochures and Posters TV Newspaper Magazines Medical campaigns Internet Radio 3.28 3.05 2.75 2.63 2.60 2.25 2.13 0.781 0.879 0.894 0.979 0.974 1.126 0.928 Gender differences Advertise Mean (SD) F-value )٭α( Females Males by TV 3.11 (0.861) 2.97 (0.860) 2.889 0.090 Newspaper 2.69 (0.924) 2.83 (0.848) 3.152 0.076 Radio 2.09 (0.934) 2.17 (0.920) 0.948 .3310 Magazines 2.63 (1.011) 2.64 (0.938) 0.022 .8830 Internet 2.19 (1.133) 2.33 (1.115) 1.933 0.165 Medical 2.61 (1.020) 2.59 (0.910) 0.059 0.808 campaigns Brochures 3.31 (0.757) 3.24 (0.812) 1.102 0.294 and posters Sources of medical information Domain Mean Physician visit 3.55 House medicines insert leaflet 2.79 Health centre visit 2.76 Pharmacist consultation 2.60 Relatives or friends 2.54 2.53 TV or radio program 2.52 Reading a related medical book 2.23 Reading brochure or poster Homeopathy 2.00 Internet search 1.97 SD .6830 .9540 1.024 .8780 .9990 .9900 1.006 .9780 .9380 1.018 Types of medicines in DTCA % Medicines Classification OTC٭ Vitamins 59.10 OTC Analgesics 57.50 OTC Anti flu 52.00 OTC Anti cough 47.40 Rx-only** For Diabetes 46.00 Rx-only Anti Acne 44.60 Rx-only For Obesity 41.10 Rx-only Antibiotics 36.60 Rx-only Contraceptives 36.50 Rx-only Anti rheumatics 36.10 OTC Anti flatulent 31.20 OTC Appetizers 30.20 Rx-only Anti cholesterol 30.20 Rx-only Gastro 29.40 Rx-only Sexual disorders 28.50 OTC + Rx-only 28.30 Dysmenorrheal Rx-only For Osteoporosis 24.60 Rx-only Anti allergy 23.60 Rx-only Cardiovascular 21.80 Rx-only Dermatological 21.40 Rx-only Asthma 20.70 Rx-only Colon 20.30 OTC Ant diarrhea 19.30 Rx-only Anticancer 17.20 Rx-only Sleep disturbances 16.80 Rx-only Antifungal 14.20 Rx-only Antidepressants 11.90 Rx-only Psychiatry 8.80 Rx-only Nocturnal 8.80 Rx-only Menopause 8.00 Rx-only Mental illness 2.30 Over The Counter Drugs, * (OTC) Prescription Only Drugs,(** Rx-only) Mean values: Sig. α ≥ 0.05 1= never, 2= rarely, 3=sometimes, 4= almost Target group response (gender wise) No. % Women > men 217 42.3 Men > women 16 3.1 Women=men 157 30.6 Not sure total 123 513 24.0 100 Gender differences of patients believes )٭α( F-value 0.186 1.756 0.985 0.000 Encourage drug marketing before making sure of its safety and efficacy 0.045 4.057 Considered as a main reason for e of increasing drug cost 0.701 0.147 Lead to buying unnecessary drugs 0.866 0.029 0.224 1.484 0.496 0.467 N=513 Less dependent on physician's diagnosis and treatment Didn’t give information about drugs’ benefits and side effects in balance Considered a good source for diagnosis and treatment Helps me to discuss disease/drug with physician/pharmacist more efficiently (SD) Mean females males (1.095) (1.129) 1.62 1.74 (1.005) (1.009) 2.38 2.37 (1.262) 2.19 (1.175) 2.35 (1.007) 2.39 (0.993) 2.59 (1.100) 2.38 (0.948) 2.40 (0.927) 2.60 (1.083) 2.30 (1.010) 2.52 (1.083) 2.45 Reasons behind targeting women > men N=217 % Yes Women are influenced more than men when 94.1 exposed to drugs advertising Women are exposed more to advertising media 89.1 Most of drugs’ advertisements are concerned 86.9 with drugs to treat women Internationally, women are in charge of health 79.0 care in the family Women visit pharmacies more than men 75.9 Gender based believes on Reasons behind targeting women > men N=513 Mean SD Less dependent on physician's diagnosis 1.67 0.871 and treatment Didn’t give information about drugs’ 2.37 0.798 benefits and side effects in balance Encourage drug marketing before 2.26 0.852 making sure of its safety and efficacy Considered as a main reason for e of 2.40 0.719 increasing drug cost Lead to buying unnecessary drugs Considered a good source for diagnosis Conclusion and treatment Prohibition of pharmaceuticals DTCA did Helps me to discuss disease/drug with not prevent Jordanians to be exposed to it physician/pharmacist more efficiently 2.60 0.698 2.35 0.855 2.49 0.816