Advanced Abstracting Issues for the Lung Cancer Diagnosis Judy Andrews, CTR Metropolitan Regional Coordinator Georgia Center for Cancer Statistics GATRA Fall Meeting 2004 ICD-O-3 CODES ICD-0-3 TERM C34.0 Main bronchus C34.1 Upper lobe, lung C34.2 Middle lobe, lung C34.3 Lower lobe, lung C34.8 Overlapping lesion of lung C34.9 Lung, NOS Anatomy Related adjectives: Lung= pneumo-, pulmono-, broncho-, bronchiolo-, alveolar, hilar Breathing= -pnea (difficulty with breathing=dyspnea) Paired organ Subsites: Right lobe: 3 lobes Left Lobe: 2 lobes Lung Anatomy Carina Upper Lobe Oblique Fissure Middle Lobe Lower Lobe Lung Anatomy: Key Words Apex Hilum Carina Lingula Cardiac Notch Pleural Cavity Chest Wall Mediastinum Base ICD-O-3 Morphology Codes Small cell lung cancers include ICD-O-3 morphology codes M-80413, M-80423, M-80433, M-80443, and M80453 Common non-small cell lung cancer histologies Squamous or epidermoid (807_3) Adenocarcinoma (814_3) Bronchioloalveolar (82503) Large cell carcinoma (80123) Other subtypes of adenocarcinoma are acinar, papillary,and mucinous Adenosquamous carcinoma (85603) Mesothelioma (905_3) Bronchogenic carcinoma IS NOT a specific cell type Regional Lymph Nodes for the Lung The regional lymph nodes for the lung are all above the diaphragm Intrathoracic nodes include mediastinal and intrapulmonary nodes Scalene and supraclavicular nodes are also considered regional nodes for staging Regional Lymph Nodes for the Lung Intrathoracic Pulmonary 12 Peribronchial 11 Intrapulmonary 10 Hilar 13 Segmental Superior mediastinal 1 Superior Mediastinal 3 Pretracheal,retrotracheal 2 Paratracheal 4 Lower paratracheal, azygos Intrathoracic Aortic 5 Subaortic (aortic window) 6 Para-aortic (ascending aorta or phrenic) Inferior mediastinal 7 Carinal, subcarinal 8 Paraesophageal 9 Pulmonary ligament Regional Lymph Nodes for the Lung Extrathoracic Scalene Supraclavicular or transverse cervical Common Metastatic Sites for the Lung Lymphatic Spread Cervical Lymph Nodes Contralateral Lung Contralateral Mediastinum Hematogenic Spread Brain Bone Liver Adrenal glands Contralateral Lung Extent of Disease Evaluation for the Lung Diagnostic Studies: Physical Exam Signs and Symptoms Palpable lymph nodes or organs Pancoast Tumor Horner’s Syndrome Extent of Disease Evaluation for the Lung Diagnostic Studies: Imaging Chest X-ray CAT Scan MRI Scan PET Scan Bone Scan Extent of Disease Evaluation for the Lung Diagnostic Studies: Endoscopies Bronchoscopy Mediastinoscopy Thoracoscopy Extent of Disease Evaluation for the Lung Diagnostic Studies: Pathological Closed Chest Needle Biopsy Cytology (Thoracentesis) Sputum Cytology Bronchial Washings Bone Marrow Biopsy Extent of Disease Evaluation for the Lung Diagnostic Studies: Tumor Markers Neuron Specific Enolase (NSE) Squamous Cell Carcinoma Antigen DNA Studies Adrenocorticotropic Hormone (ACTH) Carcinoembryonic Antigen (CEA) Calcitonin Tissue Polypeptide Antigen (TPA) Staging Systems for Lung SEER Extent of Disease 3rd Edition (Diagnosis year 1988-2003) SEER Summary Staging 2000 (Diagnosis year 2001-2003) American Joint Committee on Cancer (AJCC) TNM 6th Edition (Diagnosis year 2003 forward) Collaborative Staging (Diagnosis year 2004 forward) Staging Systems for Lung SEER EOD Size Extent Regional Lymph Nodes Reg LN Positive Reg LN Examined AJCC TNM 6th Edition cT,pT: Extent of primary tumor cN,pN: Absence or presence & Ext of regional lymph nodes cM,pM: Absence/presence of metastasis [Clinical (c) and pathologic (p)] SEER Summary Stage 2000 In Situ Localized Reg by Direct Ext Reg Ipsilateral LN only Reg by Direct & Ipsilateral Reg LN Reg, Nos Distant Site/Node Involv Collaborative Stage CS Tumor Size CS Tumor Size/Ext Eval CS Lymph Nodes CS Lymph Nodes Eval CS Mets at Dx CS Mets Eval CS Site Specific Factors 1-6 Collaborative Stage General Guidelines Timing Rule Site-specific guidelines Highest applicable number for each field Greatest extent of disease Collaborative Stage for Bronchus and Lung General Guidelines continued: CS Tumor Size/Ext CS Tumor Size/Ext Eval CS Regional LN CS Reg Nodes Eval CS Mets CS Mets Eval Regional LN Pos/Regional LN Exam Site Specific Factors Collaborative Stage for Bronchus and Lung CS Tumor Size 000 001-998 989 990 991 992-995 996 997 998 999 No mass/tumor found 001-998 millimeters (exact size) 989 millimeters or larger Microscopic focus or foci only, no size of focus given Described as less than 1 cm Described as less than (2,3,4,5 cm) Malignant cells in bronchopulmonary secretions, but no tumor is seen radiographically or during bronchoscopy Diffuse (entire lobe) Diffuse (entire lung) Unknown; size not stated Not documented in patient record Collaborative Stage for Bronchus and Lung CS Extension Primary Tumor extension DO NOT CODE DISCONTINOUS METASTASES IN THIS FIELD Priority order for extension Notes 1-7: Read carefully Collaborative Stage for Bronchus and Lung CS TS/EXT EVAL Evaluates source for “CS Tumor Size” and “CS Extension” Describes clinical or pathological staging of the tumor Collaborative Stage for Bronchus and Lung CS TS/EXT EVAL Code 0, 1, 9 Code 2 Code 3 Code 5 Code 6 Code 8 Code 9 No surgery Autopsy (diagnosis suspected) Surgery followed by other therapy Determined prior to neoadjuvant therapy Determined after neoadjuvant therapy Autopsy (diagnosis unsuspected) Unknown, Not assessed, Not stated Collaborative Stage for Bronchus and Lung CS Lymph Nodes Regional Nodes and Nodes, NOS only Highest Applicable Code Exception (NOS) New Rule for Inaccessible Site Lung Notes 1-4: Read carefully Collaborative Stage for Bronchus and Lung CS Reg Nodes Eval Code 0, 1, 9 Code 2 Code 3 Code 5 Code 6 Code 8 Code 9 No LN(s) removal Autopsy (diagnosis suspected) LN(s) surgery followed by other therapy LN(s) status determined prior to neoadjuvant therapy LN(s) status determined after neoadjuvant therapy Autopsy (diagnosis unsuspected) Unknown, Not assessed, Not stated Collaborative Stage for Bronchus and Lung Regional Nodes Positive 00 All nodes examined negative 01-89 1-89 nodes positive 90 90 or more nodes positive 95 Positive aspiration of LN(s) was performed 97 Positive nodes documented, number unspecified 98 No nodes examined 99 Unknown if nodes positive, not applicable, not stated in record Regional Nodes Examined 00 No nodes examined 01-89 1-89 nodes examined 90 90 or more nodes examined 95 No Reg LN removed, Aspiration of Reg LN performed 96 Reg LN removal documented as sampling, number unknown/not stated 97 Reg LN removal documented as dissection, number unknown/not stated 98 Reg LN surgically removed, number of LNs unknown/not stated, not documented as sampling or dissection; nodes examined, number unknown 99 Unknown, not applicable, not stated in record Collaborative Stage for Bronchus and Lung CS Mets at Dx 00 10 35 37 39 40 50 99 No; none Distant Lymph Nodes (s), including cervical nodes Separate tumor nodules (s) in different lobe, same lung Extension to sternum, skeletal muscle, skin of chest Extension to contralateral lung, contralateral main stem bronchus, separate tumor nodule(s) in contralateral lung Abdominal organs, distant metastasis except to distant lymph nodes (code 10), distant mets, NOS, carcinomatosis Distant mets + distant node(s) (10) + any [35-40] Unknown; distant metastasis cannot be assessed, not documented in patient record. Collaborative Stage for Bronchus and Lung CS Mets Eval Code 0, 1, 9 Code 2 Code 3 Code 5 Code 6 Code 8 Code 9 No surgery Autopsy (diagnosis suspected) Surgery followed by other therapy Determined prior to neoadjuvant therapy Determined after neoadjuvant therapy Autopsy (diagnosis unsuspected) Unknown, Not assessed, Not stated Collaborative Stage for Bronchus and Lung CS Site Specific Factors SSF 1 SSF 2 SSF 3 SSF 4 SSF 5 SSF 6 Code 888 Code 888 Code 888 Code 888 Code 888 Code 888 Treatment for Bronchus and Lung Surgery Non-small cell carcinoma: Stage I and II (Localized) Small cell carcinoma: Not recommended Radiation Non-small cell carcinoma: Inoperable, Advanced Small cell carcinoma: Recommended Systemic Therapy Non-small cell carcinoma: Chemotherapy Small cell carcinoma: Combination chemotherapy Hormonal & Endocrine Not proven to be useful Treatment for Bronchus and Lung Surgery Codes Primary Site Scope of Regional Lymph Node Surgical Procedure of Other Site Treatment for Bronchus and Lung Surgery Codes continued Primary Site Scope of Regional Lymph Node Surgical Procedure of Other Site Treatment for Bronchus and Lung Surgery Codes continued Primary Site Scope of Regional Lymph Node Surgical Procedure of Other Site Treatment for Bronchus and Lung Radiation Treatment Volume Treatment Modality Regional Dose Boost Modality Boost Dose Prophylactic Cranial Radiation (PCI) Treatment for Bronchus and Lung Chemotherapy Non-Small Cell Carcinoma Small Cell Carcinoma Hormones Immunotherapy Other Endoscopic Photodynamic Therapy Keys to Abstracting Organization Dates Procedure Documentation Resources Diagnosis year Text Pertinent Acronyms