Independent Assortment In meiosis I, the lining up of paternal and maternal homologues is random (or independent of what the other chromosome in the pair is doing). For a cell with 2 pairs of chromosomes (2n = 4): 4 possible combinations of chromosomes in gametes. Combinations = 22 = 4 (formula is 2x where x = # of pairs) For a cell with 3 pairs of chromosomes (2n = 6): 8 possible combinations of chromosomes in gametes. Combinations = 23 = 8 For a cell with 4 pairs of chromosomes (2n = 8): 16 possible combinations of chromosomes in gametes. Combinations = 24 = 16 Independent assortment of homologues in humans produces 223 (8,388,608) different combinations of chromosomes. Wow! The consequence of this is that no two gametes are likely to have the same genetic complement. This results in genetically varied offspring, though NO NEW genetic information has been made. Coupled with crossing over and segregation of alleles the likelihood of offspring from the same two parents being genetically the same is miniscule.