EXAM REVIEW
GI System & Respiratory System
HCl Production
Key Info to Note:
• Parietal cells contain Carbonic
Anhydrase (CAH)
• H+ pumped into stomach
lumen by H-K ATPase
• HCO3- exchanged for Cl(chloride shift)
• Alkaline tide in blood due to
increase HCO3- (Increase pH)
BLOOD
PARIETAL CELL
LUMEN OF STOMACH
Cl-
ClK+
HCO3CO2
CO2+H2OH2CO3
H+
HCl
Protein Digestion
Pyloric Gland
Gastric Gland
Pepsinogen
Food enters Stomach
Secrete Gastrin
Gastric pH
HCl
Partially
digested
protein
= Parietal Cell
= G Cell
Pepsin
(Pepsinogen+HCl)
= Chief Cell
Fat Digestion
Gastric Motility
Suppress GM?
1.
2.
3.
Activate GM?
1.
2.
3.
Pancreatic Enzymes
Trypsinogen
Enterokinase
Chymotrypsinogen
Trypsin
Precarboxypeptidase
Others:
• Pancreatic Lipase
• Pancreatic Amylase
Trypsin
Trypsin
Chymotrypsin
Carboxypeptidase
O2 Transport
On your own time, define
the following gas laws:
HENRY’S
BOYLE’S
DALTON’S
**Be able to relate these to
respiration
Hemoglobin-O2 Curve
Affinity Reduced:
• by LOW pH
• by HIGH
temperature
• by HIGH CO2
concentration