Unit 11: Abnormal Psychology
Lesson 4: Schizophrenia
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– Describe the basic differences
(neurologically and in behavior)
between MDD and bipolar disorder.
– What neurotransmitters are most
relevant in understanding anxiety
disorders?
– Write and briefly describe the causes and
symptoms of two of your disorders.
– How are these disorders treated?
Essential Question
– What are the causes, effects, and
treatment options of psychological
disorders?
•
Key Vocabulary
– Psychotic Disorders
– Schizophrenia (several types):
•
•
•
Paranoid
Disorganized
Catatonic.
– Dopamine (& relationship to
Parkinsons)
– Symptoms of Schizophrenia
•
•
•
•
Positive v. Negative symptoms
Disorganized Thinking (Delusions;
breakdowns in selective attention; word
salad)
Disturbed perceptions (hallucinations)
Inappropriate actions / feelings
– Antipsychotic medications: Haldol,
Zyprexa, Risperdol
DAILY COMMENTARY:
•
Upcoming Deadlines:
– Assigned Readings: Daily
– Present Projects: April 15-17
– Vocab Quizzes:
• Lessons 1-4: April 10th (nope. Nevermind.
Not today…
– Mock Exam:
• MC Section:
– 4/17 (Unit 11 test score will be based on
relevant questions from the mock exam)
• FRQ Section: Monday, April 13
Disorders & Therapies Project
• 30 Minutes now to research your assigned disorders
• Suggested resources:
– Myers & Griggs; web-based research; the DSM
 My disorder chart is complete. I understand the:
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•
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diagnostic criteria (symptoms)
Course & prevalence (when it sets in, how common it is)
Etiology (causes)
Treatment (medical, therapies, etc.); include at 2-3 options for each
disorder
 I have a clear understanding of how each disorder might be
treated, and can discuss the strengths and weaknesses of
different approaches to treatment
 I’ve designed an interactive, multimedia presentation on each
assigned disorder.
 I’ve practiced presenting on each disorder.
Schizophrenia
If depression is the common cold of
psychological disorders, schizophrenia is the
cancer.
Nearly 1 in a 100 suffer from schizophrenia, and
throughout the world over 24 million people
suffer from this disease (WHO, 2002).
Schizophrenia strikes young people as they
mature into adults. It affects men and women
equally, but men suffer from it more severely
than women.
3
Symptoms of Schizophrenia
The literal translation is “split mind.” A group
of severe disorders characterized by the
following:
1.
2.
3.
4.
Paranoia
Delusions
Word salad
Fragmented thinking & speech
4
Video Clips
• 4 patients with schizophrenia:
– http://www.youtube.com/watch?v=bWaFqw8Xnp
A
• San Fransisco man:
http://www.youtube.com/watch?v=rCbfpKtkhU
Disorganized & Delusional Thinking
This morning when I was at Hillside [Hospital], I was making a movie. I
was surrounded by movie stars … I’m Marry Poppins. Is this room
painted blue to get me upset? My grandmother died four weeks after my
eighteenth birthday.”
(Sheehan, 1982)
Other
forms of delusions
delusions
of
This
monologue
illustratesinclude,
fragmented,
bizarre
persecution
is following
me”) or
thinking
with (“someone
distorted beliefs
called delusions
grandeur
(“I am
a king”).
(“I’m Mary
Poppins”).
6
Disturbed Perceptions
A schizophrenic person may perceive things
that are not there (hallucinations). Frequently
such hallucinations are auditory and lesser
visual, somatosensory, olfactory, or gustatory.
L. Berthold, Untitled. The Prinzhorn Collection, University of Heidelberg
Photos of paintings by Krannert Museum, University of Illinois at Urbana-Champaign
August Natter, Witches Head. The Prinzhorn Collection, University of Heidelberg
7
Inappropriate Emotions & Actions
A schizophrenic person may laugh at the news
of someone dying or show no emotion at all
(apathy).
Patients with schizophrenia may continually
rub an arm, rock a chair, or remain motionless
for hours (catatonia).
8
Positive and Negative Symptoms
Schizophrenics have inappropriate symptoms
(hallucinations, disorganized thinking, deluded
ways) that are not present in normal individuals
(positive symptoms).
Schizophrenics also have an absence of
appropriate symptoms (apathy, expressionless
faces, rigid bodies) that are present in normal
individuals (negative symptoms).
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Chronic and Acute Schizophrenia
When schizophrenia is slow to develop
(chronic/process) recovery is doubtful. Such
schizophrenics usually display negative
symptoms.
When schizophrenia rapidly develops
(acute/reactive) recovery is better. Such
schizophrenics usually show positive
symptoms.
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Subtypes
11
Understanding Schizophrenia
Schizophrenia is a disease of the brain exhibited
by the symptoms of the mind.
Brain Abnormalities
Dopamine Overactivity: Researchers found that
schizophrenic patients express higher levels of
dopamine D4 receptors in the brain.
12
Abnormal Brain Activity
Brain scans show abnormal activity in the
frontal cortex, thalamus, and amygdala of
schizophrenic patients. Adolescent
schizophrenic patients also have brain lesions.
Paul Thompson and Arthur W. Toga, UCLA Laboratory of Neuro
Imaging and Judith L. Rapport, National Institute of Mental Health
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Abnormal Brain Morphology
Schizophrenia patients may exhibit
morphological changes in the brain like
enlargement of fluid-filled ventricles.
Both Photos: Courtesy of Daniel R. Weinberger, M.D., NIH-NIMH/ NSC
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Unit 11: Abnormal Psychology
Lesson 4: Schizophrenia (Continued)
•
•
– What are the differences between
paranoia, hallucinations, and
disorganized thinking? Give an example
of each.
– For what disorder might a psychiatrist
prescribed Zoloft (an SSRI) How about
Xanax? Lithium?
Essential Question
– What are the causes, effects, and
treatment options of psychological
disorders?
•
DAILY COMMENTARY:
Key Vocabulary
– Psychotic Disorders
– Schizophrenia (several types):
•
•
•
Paranoid
Disorganized
Catatonic.
– Dopamine (& relationship to
Parkinsons)
– Symptoms of Schizophrenia
•
•
•
•
Positive v. Negative symptoms
Disorganized Thinking (Delusions;
breakdowns in selective attention; word
salad)
Disturbed perceptions (hallucinations)
Inappropriate actions / feelings
– Antipsychotic medications: Haldol,
Zyprexa, Risperdol
•
Upcoming Deadlines:
– Assigned Readings: Daily
– Present Projects: April 15-17
– Vocab Quizzes:
• Lessons 1-7: 4/15
– Mock Exam:
• MC Section:
– 4/17 (Unit 11 test score will be based on
relevant questions from the mock exam)
• FRQ Section: Monday, April 13
Viral Infection
Schizophrenia has also been observed in
individuals who contracted a viral infection
(flu) during the middle of their fetal
development.
16
Genetic Factors
The likelihood of an individual suffering from
schizophrenia is 50% if their identical twin has
the disease (Gottesman, 1991).
0 10 20 30 40 50
Identical
Both parents
Fraternal
One parent
Sibling
Nephew or niece
Unrelated
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Genetic Factors
The following shows the prevalence of
schizophrenia in identical twins as seen in
different countries.
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Psychological Factors
Psychological and environmental factors can
trigger schizophrenia if the individual is
genetically predisposed (Nicols & Gottesman,
1983).
The genetically identical Genain
sisters suffer from schizophrenia. Two
more than others, thus there are
contributing environmental factors.
Courtesy of Genain Family
Genain Sisters
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Warning Signs
Early warning signs of schizophrenia include:
1.
A mother’s long lasting schizophrenia.
2.
Birth complications, oxygen deprivation and low-birth
weight.
3.
Short attention span and poor muscle coordination.
4.
Disruptive and withdrawn behavior.
5.
Emotional unpredictability.
6.
Poor peer relations and solo play.
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Schizophrenia Symptoms
Inappropriate symptoms
present (positive
symptoms)
Hallucinations,
disorganized thinking,
deluded ways.
Appropriate symptoms
absent (negative
symptoms)
Apathy, expressionless
faces, rigid bodies.
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Antipsychotic Drugs
Classical antipsychotics [Chlorpromazine
(Thorazine)]: Remove a number of positive
symptoms associated with schizophrenia such
as agitation, delusions, and hallucinations.
Atypical antipsychotics [Clozapine (Clozaril)]:
Remove negative symptoms associated with
schizophrenia such as apathy, jumbled thoughts,
concentration difficulties, and difficulties in
interacting with others.
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Atypical Antipsychotic
Clozapine (Clozaril) blocks receptors for
dopamine and serotonin to remove the negative
symptoms of schizophrenia.
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Researching Schizophrenia
• Complete PsychSim5 Module:
– “Losing Touch with Reality”