Training in Pathology Informatics
Funding Opportunities
Michael J. Becich, MD PhD
Course Director, APIII (http://apiii.upmc.edu)
Chairman, Dept of Biomedical Informatics
Professor of Biomedical Informatics, Pathology,
Information Science and Telecommunications
(http://www.dbmi.pitt.edu)
Center for Clinical and Translational Informatics
(http://www.ctsi.pitt.edu/content.asp?id=1435)
Overview
• NCRR - CTSA Clinical Research Training
Programs
• NLM - Biomedical Informatics Training
Programs
• Quantitative Mentored Investigator Awards
• K99/R00
• CAP Foundation and Industry Funding
• Conclusions
National Center for Research Resources
Accelerating research from basic discovery to improved patient care
community
engagement
animal model
resources
science
education
Pre-clinical
Community
Improved
patient
care
imaging &
informatics
advances
research
capacity
& training
Clinical
clinical research
support
NIH Roadmap –
http://nihroadmap.nih.gov
mouse
MRI insertion
tube
http://ctsaweb.org/
NCRR
Building A National CTSA Consortium
38 Sites with CTSA Awards since 2006 (Goal = 60)
Funded CTSA sites
First Round - 2006
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Duke Clinical and Translational Science Institute
Duke University
Irving Institute for Clinical and Translational Research
Columbia University
Mayo Center for Translational Science Activities
Mayo Clinic
Oregon Clinical and Translational Research Institute
Oregon Health and Science University
Rockefeller University Center for Clinical and Translational Science
The Rockefeller University
The UCSF Clinical and Translational Science Institute
University of California, San Francisco
UC Davis Clinical and Translational Science Center
University of California, Davis
University of Pennsylvania Institute for Translational Medicine and
Therapeutics
University of Pennsylvania
University of Pittsburgh Clinical and Translational Science Institute
University of Pittsburgh
University of Rochester Clinical and Translational Sciences Institute
University of Rochester School of Medicine and Dentistry
University of Texas Houston Center for Clinical and Translational Sciences
University of Texas Health Sciences Center at Houston
Yale Center for Clinical Investigation
Yale University
Funded CTSA sites
Second Round - 2007
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Atlanta Clinical and Translational Science Institute (Atlanta-CTSI)
Emory University (partnering with Morehouse School of Medicine)
CTSA at Case Western University
Case Western University
CTSA at Weill Cornell Medical College
Weill Cornell Medical College (partnering with Hunter College)
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins University
Michigan Institute of Clinical and Health Research
University Of Michigan At Ann Arbor
North and Central Texas Clinical and Translational Science Initiative
University of Texas Southwestern Medical Center – Dallas
University Of Wisconsin Madison Institute for Clinical and Translational
Research
University Of Wisconsin Madison
University of Chicago CTSA
University Of Chicago
University of Iowa's Institute for Clinical and Translational Science
University Of Iowa
University of Washington Institute of Translational Health Sciences
University Of Washington
Vanderbilt Institute for Clinical and Translational Research
Vanderbilt University (partnering with Meharry Medical College)
Washington University Institute of Clinical and Translational Sciences
Washington University
Funded CTSA sites
Third Round - 2008
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Albert Einstein-Montefiore Institute for Clinical and Translational Research
Albert Einstein College of Medicine (partnering with Montefiore Medical Center)
Clinical and Translational Science (BU-BRIDGE) Institute Boston University
Colorado Clinical and Translational Sciences Institute University of Colorado Denver
Harvard Catalyst: The Harvard Clinical and Translational Science Center
Harvard University
Indiana Clinical and Translational Science Institute
Indiana University School of Medicine
Institute for Integration of Medicine and Science (IIMS)
The University of Texas Health Science Center at San Antonio
Northwestern University Clinical and Translational Sciences Institute
Northwestern University
The Ohio State University Center for Clinical and Translational Science
The Ohio State University
The Scripps Translational Science Institute
The Scripps Research Institute
The Stanford Center for Clinical and Translational Education and Research
Stanford University
Translational and Clinical Science (TraCS) Institute
The University of North Carolina at Chapel Hill
Tufts Clinical and Translational Science Institute
Tufts University
UAB Center for Clinical and Translational Science
The University of Alabama at Birmingham
University of Utah Center for Clinical and Translational Science
The University of Utah
52 Sites with
CTSA Planning Grants
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Brown University
Children's Research Institute
Dartmouth College
Emory University
Georgetown University
Harvard University Medical School
Howard University
Pennington Biomedical Research Center
Medical College of Georgia
Medical College of Wisconsin
Medical University of South Carolina
Meharry Medical College
Methodist Hospital Research Institute
Michigan State University
Mount Sinai School of Medicine
New York University School of Medicine
Stanford University
State University New York
Temple University
Texas A&M University Health Science Center
Translational Genomics Research Institute
University of Massachusetts Medical School
University of Medicine Dentistry of New Jersey
University of Alabama
University of Arkansas for Medical Sciences
University of Cincinnati
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University of Colorado Denver Health Sciences
University of Connecticut School of Medicine
University of Florida
University of Hawaii
University of Illinois
University of Kansas Medical Center
University of Kentucky
University of Louisville
University of Maryland School of Medicine
University of Missouri
University of New Mexico
University of North Carolina
University of North Dakota
University of Oklahoma Health Sciences Center
University of South Carolina
University of South Florida
University of Southern California
University of Tennessee Health Science Center
University of Texas Health Science Center
University of Virginia
University of Washington
University of Wisconsin
Virginia Commonwealth University
Wake Forest University Health Sciences
Wayne State University
Weill Medical College Cornell University
Informatics at first 12 CTSA sites
MJB’s Impression (disclaimer!!!)
Data
Core, Ctr, Research Clinical
Bioinform
Site
Education Warehous
Inst, Dept
IT
Trials DB
atics
e
Columbia
Core
Yes
Yes
Yes
Duke
Core
Yes
Mayo
Core
Yes
Yes
Yes
Yes
Oregon
Core
Yes
Yes
Yes
Rockefeller Core
Yes
Yes
Yes
UC Davis
Core
Yes
Velos
Yes
Yes
UCSF
Core
Yes
Yes
Yes
Yes
Yes
U Penn Ctr(s) x 2
Yes
Yes
Yes
U Pitt
Dept, Ctr
Yes
Yes
U Rochester Core
Yes
Yes
Yes
Yes
UTHSC
Core
Yes
Yes
Yes
Yes
Yale
Core
Yes
Yes
Yes
Yes
Yes
12
8
8
7
6
Clinical
Info
Web
Portal
Yes
Yes
Yes
Vocab Architectu Biospeci
Ontology
re
men Info
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
5
Yes
Yes
5
4
3
• All Twelve CTSA sites have a component of Research IT support
– Includes implementation, enhancement, support of existing systems
• Pathology Informatics is grossly under-represented (except
maybe in Tissue Banking Informatics)
• Punch line – every program in CTSA (as a requirement for
funding) has to have a training program in clinical research and
have a biomedical informatics core!!!
Yes
3
CTSA Training Programs
• CTSA has (by requirement) training programs (K and T
programs of NIH) and clinical and translational research
centers (CTRCs, formerly GCRCs)
• K Programs (for junior faculty) –
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Career Development and Mentorship Programs
Clinical Research Scholars Program
Focus is to take MDs and train them in clinical research
Pathology is not taking advantage of this major opportunity
• T Programs (for residents and fellows)
• Clinical Research Training Program
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Certificate program (1 yr) available at most institutions
• Designed for trainees – clinical & translational research fellowship
• Pathology is not taking advantage of this major opportunity
Total number of active trainees
160
140
120
Non-degree
Students
Residents
CRSP (K12)
CETP
CRTP
100
80
60
40
20
0
2000
2001
2001
2003
2004
2005
2006
NLM Biomedical Informatics
Training Programs = 20
http://www.nlm.nih.gov/ep/GrantTrainInstitute.html
NLM Biomedical Informatics
Training Programs = 18
• 1. University of California Irvine Irvine, CA, Program contact: Pierre Baldi
• 2. University of California Los Angeles Los Angeles, CA, Program contact: Alex Bui
• 3. Stanford University Stanford, CA, Program contact: Russ Altman
• 4. University of Colorado Denver/ Aurora, CO, Program contact: Larry Hunter
• 5. Yale University New Haven, CT, Program contact: Sandra Frawley
• 6. Regenstrief/Indiana University Indianapolis, IN, Program contact: Steve Downs
• 7. Harvard University Boston, MA, Program contact: Lucila Ohno-Machado
• 8. Johns Hopkins University Baltimore, MD, Program contact: Kersti Winny
• 9. University of Missouri-Columbia Columbia, MO, Program contact: Bill Caldwell
• 10. Columbia University Health Sciences NY, NY Program contact: Marina Honablue
• 11. Oregon Health & Science University Portland, OR; Program contact: Bill Hersh
• 12. University of Pittsburgh Pittsburgh, PA; Program contact: Toni Porterfield
• 13. Vanderbilt University Nashville, TN; Program contact: Cindy Gadd
• 14. Rice University Houston, TX; Program contact: Tony Gorry
• 15. University of Utah Salt Lake City, UT; Program contact: Scott Narus
• 16. University of Virginia Charlottesville, VA; Program contact: Stephanie Guerlain
• 17. University of Washington Seattle, WA; Program contact: Brian Brown
• 18. University of Wisconsin Madison Madison, WI; Program contact: Louise Pape
NOTE: Red #s are sites that do not yet have a CTSA Funded Training Program
NLM Training Programs
• Focused on 3 types of training:
– PhD – major focus
– MS – major focus
– Certificates (one year generally) – excellent for
Pathology Informatics trainees
• Great for informatics networking even if your
program is “stand alone”
• Short term training opportunities also available –
summer, 3 month rotation
• Major demand see 10x10 program –
http://www.amia.org/10x10
Quantitative Mentored Investigator
Award (K25)
http://grants.nih.gov/grants/guide/pa-files/PA-06-087.html
The K25 award will provide support and “protected time” for a period of
supervised study and research for productive professionals with quantitative
(e.g., mathematics, statistics, economics, computer science, imaging science,
informatics, physics, chemistry) and engineering backgrounds to integrate their
expertise with NIH-relevant research.
Requires mentor
Requires training plan
Requires research plan
K99/R00 (so called “kangaroo”)
Pathway to Independence Awards
Purpose
The NIH Pathway to Independence Award will provide up to five years of support
consisting of two phases. The initial phase will provide 1-2 years of mentored
support for highly promising, postdoctoral research scientists. This phase will be
followed by up to 3 years of independent support contingent on securing an
independent research position. The PI Award is limited to postdoctoral trainees. This
program expires January 3, 2010 unless reissued.
NLM supports research career development in biomedical informatics and
bioinformatics. We define informatics as the intersection of computer, information
and behavioral sciences with one or more application domains. Application domains
of interest include health care delivery, basic biomedical research, clinical and
translational research, public health and others. Whatever the application domain,
the research career focus must be informatics. Preference will be given to applicants
who received their informatics training at one of NLM's university-based training
programs in Biomedical Informatics.
NLM Contact
Clinical and Public Health Informatics: Dr. Hua-Chuan Sim, simh@mail.nih.gov
Bioinformatics and Computational Biology: Dr. Jane Ye, yej@mail.nih.gov
Deadlines for New Applications: February 12, June 12, and October 12 each year
Deadlines for Revised Applications: March 12, July 12, and November 12 each year
Full listing of deadlines for competing applications:
http://www.nlm.nih.gov/ep/Deadlines.html
CAP Foundation
Scholars Research Program – sponsored by CAP and Seracon
Award Amount: Up to $12,500 for six months Up to $25,000 for one year
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Intended for salary support. Recipient’s institution is expected to contribute benefits and
overhead costs and may provide a support supplement. Assurance must be given that
facilities and direct support sufficient for the work proposed by the applicant will be provided
throughout the term of the grant.
This award is made to the scholar, not the institution. It may, with cause, be terminated at
any time. Recipients who choose not to accept the award may list the recognition on their
curriculum vitae.
Purpose: The purpose of the award is to help facilitate the transition from residency to an
independent investigator. Therefore, persons who have already been awarded major
research support for the previous academic year will not be eligible.
Time Commitment: Projects must be completed within one (1) year. For those who are in
a second year fellowship, the project must be completed within three (3) years after
completing residency. Applicants must plan to spend their fellowship year in basic or
applied research, and are expected to work full-time as defined in their project plan.
Eligibility: Residents at the PGY 2 level, and up to those doing a second year fellowship.
Residents who are more than three years post-residency training are not eligible.
Applicants must be a CAP Member or have an application pending.
http://www.cap.org/apps/cap.portal?_nfpb=true&_pageLabel=foundation
CAP Foundation
Advanced Training in Pathology Informatics - Sponsored by McKesson
• Award Amount: Allowance provided for travel and living expenses. It is
expected that the recipient’s own institution will continue to provide for salary and
benefits during the award period.
• Purpose: To offer background and experience to pathology residents to
introduce and implement advanced informatics technology in the clinical
laboratory. After the rotation, the resident will be able to:
• Identify the following factors important in introducing and utilizing new information
technology in the clinical laboratory:
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Medical decision support systems and artificial intelligence
Electronic medical record
Digital multimedia and imaging applications
Telepathology and telemedicine
Outcomes research and data mining
Process control, quality control, and quality assurance
Demonstrate ability to recognize and utilize information concerning new trends
and technology in pathology.
Commitment: Four (4) weeks, must be completed between 5/1/09 – 8/31/09.
Eligibility: Pathology residents or those in fellowships. It is a requirement that
candidates have adequate training and experience in informatics. Applicants
must be a CAP Junior Member.
CAP Foundation
Research in Telepathology - Sponsored by Nikon
• Award Amount: $5,000 to cover expenses incurred during
the grant period, and for travel to attend a national meeting
to present an abstract/paper summarizing study results.
• Purpose: To further developments in and use of information
technology for the practice of pathology.
• Time Commitment: This grant is intended to facilitate a sixmonth study.
• Eligibility: Pathology residents and those in fellowships who
are still in training. Applicants must be a CAP Junior Member
or have an application pending.
CAP Foundation
Research in Telepathology - Sponsored by Olympus
• Award Amount: $5,000 to cover expenses incurred during
the grant period, and for travel to attend a national meeting
to present an abstract/paper summarizing study results.
• Purpose: To further developments in and use of information
technology for the practice of pathology.
• Time Commitment: This grant is intended to facilitate a sixmonth study.
• Eligibility: Pathology residents and those in fellowships who
are still in training. Applicants must be a CAP Junior Member
or have an application pending.
Conclusions
• Pathology Informatics trainees should
consider clinical research training
programs in CTSA sites – 38
• Pathology Informatics trainees should
consider biomedical informatics training
programs – 18
• Other funding opportunities exist in your
institution, foundations and from industry
– Communicate with CAP Foundation
• Make it happen, there are options!!!
End of Talk – e-mail me at becich@pitt.edu if
you have questions or need clarifications
about the discussion.
NOTE: Please e-mail me if you want a copy of this
presentation or contact me for additional help in training
resources nationally – 412-623-3941